Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis
•Inflammatory bowel disease (IBD) refers to diseases that cause inflammation of the intestinal wall.•Flaxseed is a rich source of omega-3 fatty acids (α-linolenic acid; ALA), phytoestrogens and soluble fiber.•flaxseed and flaxseed oil, attenuate inflammatory markers, disease severity, blood pressure...
Gespeichert in:
| Veröffentlicht in: | Complementary therapies in medicine 2019-10, Vol.46, p.36-43 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 43 |
|---|---|
| container_issue | |
| container_start_page | 36 |
| container_title | Complementary therapies in medicine |
| container_volume | 46 |
| creator | Morshedzadeh, Nava Shahrokh, Shabnam Aghdaei, Hamid Asadzadeh Amin Pourhoseingholi, Mohamad Chaleshi, Vahid Hekmatdoost, Azita Karimi, Soheila Zali, Mohammad Reza Mirmiran, Parvin |
| description | •Inflammatory bowel disease (IBD) refers to diseases that cause inflammation of the intestinal wall.•Flaxseed is a rich source of omega-3 fatty acids (α-linolenic acid; ALA), phytoestrogens and soluble fiber.•flaxseed and flaxseed oil, attenuate inflammatory markers, disease severity, blood pressure, and WC.
The present study aimed to evaluate the possible effect of grounded flaxseed and flaxseed oil on serum levels of inflammatory markers, metabolic parameters, and the severity of disease in patients with UC.
In this open-labeled randomized controlled trial, 90 UC patients were randomly assigned to one of the 3 groups for 12 weeks: grounded flaxseed (GF; 30 g/day), flaxseed oil (FO; 10 g/day) and control group. The weight, waist circumference, systolic and diastolic blood pressure, serum inflammatory markers (interleukin-6 (IL-6), interferon gamma (INF-γ), transforming growth factor beta (TGF-β), and Erythrocyte Sedimentation Rate (ESR)), and fecal calprotectin were measured at the baseline and end of the study.
Totally, 75 patients (43 men and 32 women) with a mean age of 31.54 ± 9.84 years participated in the present study. Comparing the change of the variables indicated a significant decrease in fecal calprotectin (P |
| doi_str_mv | 10.1016/j.ctim.2019.07.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2290837806</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0965229919306922</els_id><sourcerecordid>2287407199</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-2f31bd82b4ad1e114af54b87665914fb86039ec74eaf891da0b49610ff17d9ea3</originalsourceid><addsrcrecordid>eNp9kcuKFDEUhoMoTjv6Ai4k4MaFVSaVuiTgRobxAgNudB1SyQmmTV1MUq39SL6lp6dHBReuwgnf_yecj5CnnNWc8f7VvrYlTHXDuKrZUDPe3CM7LgdR9aoX98mOqb6rmkapC_Io5z1jTIlBPCQXgndcNbLbkZ_X3oMtmS6e-mh-ZABHzez-DkuING_rGmGCudBlphnSNtEIB4i3uTAjPE2mLOlIJ5O-Qsov6QTFjEsMlq4mGZzw9rY5YzCFcjxFXchgMmAFUiXgA5l-D-UL3aKFhDcHoBZLSsiPyQNvYoYnd-cl-fz2-tPV--rm47sPV29uKitkW6rGCz462YytcRw4b43v2lEOfd8p3vpR9kwosEMLxkvFnWFjq3rOvOeDU2DEJXlx7l3T8m2DXPQUsoUYzQzLljXuk0kxSNYj-vwfdL9sacbfISWHlg1cKaSaM2XTknMCr9cUcE1HzZk-idR7fRKpTyI1GzSKxNCzu-ptnMD9ifw2h8DrM4AS4BAg6WxxfxZcSChUuyX8r_8Xx2WzAA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2287407199</pqid></control><display><type>article</type><title>Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>ProQuest Central UK/Ireland</source><creator>Morshedzadeh, Nava ; Shahrokh, Shabnam ; Aghdaei, Hamid Asadzadeh ; Amin Pourhoseingholi, Mohamad ; Chaleshi, Vahid ; Hekmatdoost, Azita ; Karimi, Soheila ; Zali, Mohammad Reza ; Mirmiran, Parvin</creator><creatorcontrib>Morshedzadeh, Nava ; Shahrokh, Shabnam ; Aghdaei, Hamid Asadzadeh ; Amin Pourhoseingholi, Mohamad ; Chaleshi, Vahid ; Hekmatdoost, Azita ; Karimi, Soheila ; Zali, Mohammad Reza ; Mirmiran, Parvin</creatorcontrib><description><![CDATA[•Inflammatory bowel disease (IBD) refers to diseases that cause inflammation of the intestinal wall.•Flaxseed is a rich source of omega-3 fatty acids (α-linolenic acid; ALA), phytoestrogens and soluble fiber.•flaxseed and flaxseed oil, attenuate inflammatory markers, disease severity, blood pressure, and WC.
The present study aimed to evaluate the possible effect of grounded flaxseed and flaxseed oil on serum levels of inflammatory markers, metabolic parameters, and the severity of disease in patients with UC.
In this open-labeled randomized controlled trial, 90 UC patients were randomly assigned to one of the 3 groups for 12 weeks: grounded flaxseed (GF; 30 g/day), flaxseed oil (FO; 10 g/day) and control group. The weight, waist circumference, systolic and diastolic blood pressure, serum inflammatory markers (interleukin-6 (IL-6), interferon gamma (INF-γ), transforming growth factor beta (TGF-β), and Erythrocyte Sedimentation Rate (ESR)), and fecal calprotectin were measured at the baseline and end of the study.
Totally, 75 patients (43 men and 32 women) with a mean age of 31.54 ± 9.84 years participated in the present study. Comparing the change of the variables indicated a significant decrease in fecal calprotectin (P < 0.001), Mayo score (P < 0.001), ESR (P < 0.001), INF-γ (P < 0.001), IL-6 (P < 0.001), waist circumference (P = 0.02), Diastolic Blood Pressure (DBP) (P < 0.001), and Systolic Blood Pressure (SBP) (P < 0.001) and a significant increase in TGF-β (P < 0.001) and Inflammatory Bowel Disease Questionnaire-Short form (IBDQ-9) score (P < 0.001) in the GF and FO groups compared to the control. No difference was obvious between the FO and GF groups except for TGF-β.
The present study showed that both flaxseed and flaxseed oil, attenuate inflammatory markers, disease severity, blood pressure, and WC. However, the effect of flaxseed on weight and BMI was not evident.]]></description><identifier>ISSN: 0965-2299</identifier><identifier>EISSN: 1873-6963</identifier><identifier>DOI: 10.1016/j.ctim.2019.07.012</identifier><identifier>PMID: 31519285</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Adult ; Biomarkers - blood ; Blood pressure ; Blood Pressure - drug effects ; Body Weight - drug effects ; Colitis, Ulcerative - blood ; Colitis, Ulcerative - drug therapy ; Cytokines ; Diet ; Dietary Supplements ; Disease control ; Erythrocyte sedimentation rate ; Erythrocytes ; Fatty acids ; Female ; Flax - chemistry ; Flaxseed ; Flaxseed oil ; Growth factors ; Humans ; Infectious diseases ; Inflammation ; Inflammation - blood ; Inflammation Mediators - blood ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Interferon ; Interleukin 6 ; Interleukins ; Intestine ; Linseed Oil - pharmacology ; Linseed Oil - therapeutic use ; Male ; Markers ; Metabolism ; Nutrition research ; Oil ; Oilseeds ; Oxidative Stress - drug effects ; Pathogenesis ; Proteins ; Serum levels ; Severity ; Severity of Illness Index ; Transforming growth factor-b ; Tumor necrosis factor-TNF ; Ulcerative colitis ; Waist Circumference - drug effects ; Weight</subject><ispartof>Complementary therapies in medicine, 2019-10, Vol.46, p.36-43</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><rights>2019. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-2f31bd82b4ad1e114af54b87665914fb86039ec74eaf891da0b49610ff17d9ea3</citedby><cites>FETCH-LOGICAL-c384t-2f31bd82b4ad1e114af54b87665914fb86039ec74eaf891da0b49610ff17d9ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2287407199?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974,64362,64364,64366,72216</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31519285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morshedzadeh, Nava</creatorcontrib><creatorcontrib>Shahrokh, Shabnam</creatorcontrib><creatorcontrib>Aghdaei, Hamid Asadzadeh</creatorcontrib><creatorcontrib>Amin Pourhoseingholi, Mohamad</creatorcontrib><creatorcontrib>Chaleshi, Vahid</creatorcontrib><creatorcontrib>Hekmatdoost, Azita</creatorcontrib><creatorcontrib>Karimi, Soheila</creatorcontrib><creatorcontrib>Zali, Mohammad Reza</creatorcontrib><creatorcontrib>Mirmiran, Parvin</creatorcontrib><title>Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis</title><title>Complementary therapies in medicine</title><addtitle>Complement Ther Med</addtitle><description><![CDATA[•Inflammatory bowel disease (IBD) refers to diseases that cause inflammation of the intestinal wall.•Flaxseed is a rich source of omega-3 fatty acids (α-linolenic acid; ALA), phytoestrogens and soluble fiber.•flaxseed and flaxseed oil, attenuate inflammatory markers, disease severity, blood pressure, and WC.
The present study aimed to evaluate the possible effect of grounded flaxseed and flaxseed oil on serum levels of inflammatory markers, metabolic parameters, and the severity of disease in patients with UC.
In this open-labeled randomized controlled trial, 90 UC patients were randomly assigned to one of the 3 groups for 12 weeks: grounded flaxseed (GF; 30 g/day), flaxseed oil (FO; 10 g/day) and control group. The weight, waist circumference, systolic and diastolic blood pressure, serum inflammatory markers (interleukin-6 (IL-6), interferon gamma (INF-γ), transforming growth factor beta (TGF-β), and Erythrocyte Sedimentation Rate (ESR)), and fecal calprotectin were measured at the baseline and end of the study.
Totally, 75 patients (43 men and 32 women) with a mean age of 31.54 ± 9.84 years participated in the present study. Comparing the change of the variables indicated a significant decrease in fecal calprotectin (P < 0.001), Mayo score (P < 0.001), ESR (P < 0.001), INF-γ (P < 0.001), IL-6 (P < 0.001), waist circumference (P = 0.02), Diastolic Blood Pressure (DBP) (P < 0.001), and Systolic Blood Pressure (SBP) (P < 0.001) and a significant increase in TGF-β (P < 0.001) and Inflammatory Bowel Disease Questionnaire-Short form (IBDQ-9) score (P < 0.001) in the GF and FO groups compared to the control. No difference was obvious between the FO and GF groups except for TGF-β.
The present study showed that both flaxseed and flaxseed oil, attenuate inflammatory markers, disease severity, blood pressure, and WC. However, the effect of flaxseed on weight and BMI was not evident.]]></description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Colitis, Ulcerative - blood</subject><subject>Colitis, Ulcerative - drug therapy</subject><subject>Cytokines</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Disease control</subject><subject>Erythrocyte sedimentation rate</subject><subject>Erythrocytes</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Flax - chemistry</subject><subject>Flaxseed</subject><subject>Flaxseed oil</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation Mediators - blood</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Interferon</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>Intestine</subject><subject>Linseed Oil - pharmacology</subject><subject>Linseed Oil - therapeutic use</subject><subject>Male</subject><subject>Markers</subject><subject>Metabolism</subject><subject>Nutrition research</subject><subject>Oil</subject><subject>Oilseeds</subject><subject>Oxidative Stress - drug effects</subject><subject>Pathogenesis</subject><subject>Proteins</subject><subject>Serum levels</subject><subject>Severity</subject><subject>Severity of Illness Index</subject><subject>Transforming growth factor-b</subject><subject>Tumor necrosis factor-TNF</subject><subject>Ulcerative colitis</subject><subject>Waist Circumference - drug effects</subject><subject>Weight</subject><issn>0965-2299</issn><issn>1873-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kcuKFDEUhoMoTjv6Ai4k4MaFVSaVuiTgRobxAgNudB1SyQmmTV1MUq39SL6lp6dHBReuwgnf_yecj5CnnNWc8f7VvrYlTHXDuKrZUDPe3CM7LgdR9aoX98mOqb6rmkapC_Io5z1jTIlBPCQXgndcNbLbkZ_X3oMtmS6e-mh-ZABHzez-DkuING_rGmGCudBlphnSNtEIB4i3uTAjPE2mLOlIJ5O-Qsov6QTFjEsMlq4mGZzw9rY5YzCFcjxFXchgMmAFUiXgA5l-D-UL3aKFhDcHoBZLSsiPyQNvYoYnd-cl-fz2-tPV--rm47sPV29uKitkW6rGCz462YytcRw4b43v2lEOfd8p3vpR9kwosEMLxkvFnWFjq3rOvOeDU2DEJXlx7l3T8m2DXPQUsoUYzQzLljXuk0kxSNYj-vwfdL9sacbfISWHlg1cKaSaM2XTknMCr9cUcE1HzZk-idR7fRKpTyI1GzSKxNCzu-ptnMD9ifw2h8DrM4AS4BAg6WxxfxZcSChUuyX8r_8Xx2WzAA</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Morshedzadeh, Nava</creator><creator>Shahrokh, Shabnam</creator><creator>Aghdaei, Hamid Asadzadeh</creator><creator>Amin Pourhoseingholi, Mohamad</creator><creator>Chaleshi, Vahid</creator><creator>Hekmatdoost, Azita</creator><creator>Karimi, Soheila</creator><creator>Zali, Mohammad Reza</creator><creator>Mirmiran, Parvin</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201910</creationdate><title>Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis</title><author>Morshedzadeh, Nava ; Shahrokh, Shabnam ; Aghdaei, Hamid Asadzadeh ; Amin Pourhoseingholi, Mohamad ; Chaleshi, Vahid ; Hekmatdoost, Azita ; Karimi, Soheila ; Zali, Mohammad Reza ; Mirmiran, Parvin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-2f31bd82b4ad1e114af54b87665914fb86039ec74eaf891da0b49610ff17d9ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Colitis, Ulcerative - blood</topic><topic>Colitis, Ulcerative - drug therapy</topic><topic>Cytokines</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Disease control</topic><topic>Erythrocyte sedimentation rate</topic><topic>Erythrocytes</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Flax - chemistry</topic><topic>Flaxseed</topic><topic>Flaxseed oil</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Inflammation Mediators - blood</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Interferon</topic><topic>Interleukin 6</topic><topic>Interleukins</topic><topic>Intestine</topic><topic>Linseed Oil - pharmacology</topic><topic>Linseed Oil - therapeutic use</topic><topic>Male</topic><topic>Markers</topic><topic>Metabolism</topic><topic>Nutrition research</topic><topic>Oil</topic><topic>Oilseeds</topic><topic>Oxidative Stress - drug effects</topic><topic>Pathogenesis</topic><topic>Proteins</topic><topic>Serum levels</topic><topic>Severity</topic><topic>Severity of Illness Index</topic><topic>Transforming growth factor-b</topic><topic>Tumor necrosis factor-TNF</topic><topic>Ulcerative colitis</topic><topic>Waist Circumference - drug effects</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morshedzadeh, Nava</creatorcontrib><creatorcontrib>Shahrokh, Shabnam</creatorcontrib><creatorcontrib>Aghdaei, Hamid Asadzadeh</creatorcontrib><creatorcontrib>Amin Pourhoseingholi, Mohamad</creatorcontrib><creatorcontrib>Chaleshi, Vahid</creatorcontrib><creatorcontrib>Hekmatdoost, Azita</creatorcontrib><creatorcontrib>Karimi, Soheila</creatorcontrib><creatorcontrib>Zali, Mohammad Reza</creatorcontrib><creatorcontrib>Mirmiran, Parvin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Complementary therapies in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morshedzadeh, Nava</au><au>Shahrokh, Shabnam</au><au>Aghdaei, Hamid Asadzadeh</au><au>Amin Pourhoseingholi, Mohamad</au><au>Chaleshi, Vahid</au><au>Hekmatdoost, Azita</au><au>Karimi, Soheila</au><au>Zali, Mohammad Reza</au><au>Mirmiran, Parvin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis</atitle><jtitle>Complementary therapies in medicine</jtitle><addtitle>Complement Ther Med</addtitle><date>2019-10</date><risdate>2019</risdate><volume>46</volume><spage>36</spage><epage>43</epage><pages>36-43</pages><issn>0965-2299</issn><eissn>1873-6963</eissn><abstract><![CDATA[•Inflammatory bowel disease (IBD) refers to diseases that cause inflammation of the intestinal wall.•Flaxseed is a rich source of omega-3 fatty acids (α-linolenic acid; ALA), phytoestrogens and soluble fiber.•flaxseed and flaxseed oil, attenuate inflammatory markers, disease severity, blood pressure, and WC.
The present study aimed to evaluate the possible effect of grounded flaxseed and flaxseed oil on serum levels of inflammatory markers, metabolic parameters, and the severity of disease in patients with UC.
In this open-labeled randomized controlled trial, 90 UC patients were randomly assigned to one of the 3 groups for 12 weeks: grounded flaxseed (GF; 30 g/day), flaxseed oil (FO; 10 g/day) and control group. The weight, waist circumference, systolic and diastolic blood pressure, serum inflammatory markers (interleukin-6 (IL-6), interferon gamma (INF-γ), transforming growth factor beta (TGF-β), and Erythrocyte Sedimentation Rate (ESR)), and fecal calprotectin were measured at the baseline and end of the study.
Totally, 75 patients (43 men and 32 women) with a mean age of 31.54 ± 9.84 years participated in the present study. Comparing the change of the variables indicated a significant decrease in fecal calprotectin (P < 0.001), Mayo score (P < 0.001), ESR (P < 0.001), INF-γ (P < 0.001), IL-6 (P < 0.001), waist circumference (P = 0.02), Diastolic Blood Pressure (DBP) (P < 0.001), and Systolic Blood Pressure (SBP) (P < 0.001) and a significant increase in TGF-β (P < 0.001) and Inflammatory Bowel Disease Questionnaire-Short form (IBDQ-9) score (P < 0.001) in the GF and FO groups compared to the control. No difference was obvious between the FO and GF groups except for TGF-β.
The present study showed that both flaxseed and flaxseed oil, attenuate inflammatory markers, disease severity, blood pressure, and WC. However, the effect of flaxseed on weight and BMI was not evident.]]></abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>31519285</pmid><doi>10.1016/j.ctim.2019.07.012</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0965-2299 |
| ispartof | Complementary therapies in medicine, 2019-10, Vol.46, p.36-43 |
| issn | 0965-2299 1873-6963 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2290837806 |
| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Adult Biomarkers - blood Blood pressure Blood Pressure - drug effects Body Weight - drug effects Colitis, Ulcerative - blood Colitis, Ulcerative - drug therapy Cytokines Diet Dietary Supplements Disease control Erythrocyte sedimentation rate Erythrocytes Fatty acids Female Flax - chemistry Flaxseed Flaxseed oil Growth factors Humans Infectious diseases Inflammation Inflammation - blood Inflammation Mediators - blood Inflammatory bowel disease Inflammatory bowel diseases Interferon Interleukin 6 Interleukins Intestine Linseed Oil - pharmacology Linseed Oil - therapeutic use Male Markers Metabolism Nutrition research Oil Oilseeds Oxidative Stress - drug effects Pathogenesis Proteins Serum levels Severity Severity of Illness Index Transforming growth factor-b Tumor necrosis factor-TNF Ulcerative colitis Waist Circumference - drug effects Weight |
| title | Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T08%3A53%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20flaxseed%20and%20flaxseed%20oil%20supplement%20on%20serum%20levels%20of%20inflammatory%20markers,%20metabolic%20parameters%20and%20severity%20of%20disease%20in%20patients%20with%20ulcerative%20colitis&rft.jtitle=Complementary%20therapies%20in%20medicine&rft.au=Morshedzadeh,%20Nava&rft.date=2019-10&rft.volume=46&rft.spage=36&rft.epage=43&rft.pages=36-43&rft.issn=0965-2299&rft.eissn=1873-6963&rft_id=info:doi/10.1016/j.ctim.2019.07.012&rft_dat=%3Cproquest_cross%3E2287407199%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2287407199&rft_id=info:pmid/31519285&rft_els_id=S0965229919306922&rfr_iscdi=true |