Ischaemia–reperfusion injury with Pringle's maneuver induces unusually large von Willebrand factor multimers after hepatectomy

AbstractIntroductionvon Willebrand factor (VWF) is synthesised in vascular endothelial cells and released into the plasma as unusually large VWF multimers (UL-VWFMs). Sinusoidal endothelial cells are a major target of ischaemia–reperfusion injury due to liver surgery. This study aimed to clarify the...

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Veröffentlicht in:	Thrombosis research 2019-11, Vol.183, p.20-27
Hauptverfasser:	Yoshikawa, Takahiro, Nomi, Takeo, Sakai, Kazuya, Hayakawa, Masaki, Hokuto, Daisuke, Matsuo, Yasuko, Sho, Masayuki, Matsumoto, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAMTS13 Aged Aged, 80 and over Cohort Studies Female Hematology, Oncology, and Palliative Medicine Hepatectomy Hepatectomy - adverse effects Hepatectomy - methods Humans Male Middle Aged Prospective Studies Reperfusion Injury - complications Unusually large VWF multimers von Willebrand Factor - metabolism
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