Ischaemia–reperfusion injury with Pringle's maneuver induces unusually large von Willebrand factor multimers after hepatectomy
AbstractIntroductionvon Willebrand factor (VWF) is synthesised in vascular endothelial cells and released into the plasma as unusually large VWF multimers (UL-VWFMs). Sinusoidal endothelial cells are a major target of ischaemia–reperfusion injury due to liver surgery. This study aimed to clarify the...
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| Veröffentlicht in: | Thrombosis research 2019-11, Vol.183, p.20-27 |
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| creator | Yoshikawa, Takahiro Nomi, Takeo Sakai, Kazuya Hayakawa, Masaki Hokuto, Daisuke Matsuo, Yasuko Sho, Masayuki Matsumoto, Masanori |
| description | AbstractIntroductionvon Willebrand factor (VWF) is synthesised in vascular endothelial cells and released into the plasma as unusually large VWF multimers (UL-VWFMs). Sinusoidal endothelial cells are a major target of ischaemia–reperfusion injury due to liver surgery. This study aimed to clarify the effect of hepatectomy on UL-VWFMs. Materials and methodsThirty-five patients who underwent hepatectomy were eligible for the study. Plasma ADAMTS13 activity and VWF antigen levels were measured by enzyme-linked immunosorbent assay and multimer analysis of plasma VWF was performed according to Ruggeri and Zimmerman's method. For analyses, patients were categorised according to UL-VWFM positivity after hepatectomy. ResultsPlasma ADAMTS13 activity significantly decreased from 61.0% (27.7%–126.2%) before operation to 37.4% (20.2%–71.4%) on postoperative day 7 ( p |
| doi_str_mv | 10.1016/j.thromres.2019.09.005 |
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Sinusoidal endothelial cells are a major target of ischaemia–reperfusion injury due to liver surgery. This study aimed to clarify the effect of hepatectomy on UL-VWFMs. Materials and methodsThirty-five patients who underwent hepatectomy were eligible for the study. Plasma ADAMTS13 activity and VWF antigen levels were measured by enzyme-linked immunosorbent assay and multimer analysis of plasma VWF was performed according to Ruggeri and Zimmerman's method. For analyses, patients were categorised according to UL-VWFM positivity after hepatectomy. ResultsPlasma ADAMTS13 activity significantly decreased from 61.0% (27.7%–126.2%) before operation to 37.4% (20.2%–71.4%) on postoperative day 7 ( p < 0.001). Plasma VWF antigen levels significantly increased from 172.1% (80.5%–412.8%) before operation to 361.0% (154.7%–745.8%) on postoperative day 2, which remained high until postoperative day 7 ( p < 0.001). Seven patients remained UL-VWFMs-negative and 22 patients became UL-VWFMs-positive after operation. Pringle's maneuver duration was significantly longer and blood loss volume was significantly higher in the UL-VWFMs-positive group ( p = 0.001 and p = 0.003, respectively). By multivariable analysis, Pringle's maneuver duration [odds ratio 1.049, 95% confidence interval (CI) 1.001–1.098; p = 0.043] was significantly associated with increased UL-VWFMs level after hepatectomy. UL-VWFMs index was significantly correlated with Pringle's maneuver duration (r = 0.444, p = 0.017). ConclusionsPlasma UL-VWFMs levels increased after hepatectomy due to ischaemia–reperfusion injury with Pringle's maneuver.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/j.thromres.2019.09.005</identifier><identifier>PMID: 31518960</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>ADAMTS13 ; Aged ; Aged, 80 and over ; Cohort Studies ; Female ; Hematology, Oncology, and Palliative Medicine ; Hepatectomy ; Hepatectomy - adverse effects ; Hepatectomy - methods ; Humans ; Male ; Middle Aged ; Prospective Studies ; Reperfusion Injury - complications ; Unusually large VWF multimers ; von Willebrand Factor - metabolism</subject><ispartof>Thrombosis research, 2019-11, Vol.183, p.20-27</ispartof><rights>Elsevier Ltd</rights><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c599t-71217de0616078b2c48d2638fbaf880d7cd96175e4be082394583dc23fcc82f23</citedby><cites>FETCH-LOGICAL-c599t-71217de0616078b2c48d2638fbaf880d7cd96175e4be082394583dc23fcc82f23</cites><orcidid>0000-0002-7243-3126 ; 0000-0003-0523-7931</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.thromres.2019.09.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31518960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshikawa, Takahiro</creatorcontrib><creatorcontrib>Nomi, Takeo</creatorcontrib><creatorcontrib>Sakai, Kazuya</creatorcontrib><creatorcontrib>Hayakawa, Masaki</creatorcontrib><creatorcontrib>Hokuto, Daisuke</creatorcontrib><creatorcontrib>Matsuo, Yasuko</creatorcontrib><creatorcontrib>Sho, Masayuki</creatorcontrib><creatorcontrib>Matsumoto, Masanori</creatorcontrib><title>Ischaemia–reperfusion injury with Pringle's maneuver induces unusually large von Willebrand factor multimers after hepatectomy</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>AbstractIntroductionvon Willebrand factor (VWF) is synthesised in vascular endothelial cells and released into the plasma as unusually large VWF multimers (UL-VWFMs). Sinusoidal endothelial cells are a major target of ischaemia–reperfusion injury due to liver surgery. This study aimed to clarify the effect of hepatectomy on UL-VWFMs. Materials and methodsThirty-five patients who underwent hepatectomy were eligible for the study. Plasma ADAMTS13 activity and VWF antigen levels were measured by enzyme-linked immunosorbent assay and multimer analysis of plasma VWF was performed according to Ruggeri and Zimmerman's method. For analyses, patients were categorised according to UL-VWFM positivity after hepatectomy. ResultsPlasma ADAMTS13 activity significantly decreased from 61.0% (27.7%–126.2%) before operation to 37.4% (20.2%–71.4%) on postoperative day 7 ( p < 0.001). Plasma VWF antigen levels significantly increased from 172.1% (80.5%–412.8%) before operation to 361.0% (154.7%–745.8%) on postoperative day 2, which remained high until postoperative day 7 ( p < 0.001). Seven patients remained UL-VWFMs-negative and 22 patients became UL-VWFMs-positive after operation. Pringle's maneuver duration was significantly longer and blood loss volume was significantly higher in the UL-VWFMs-positive group ( p = 0.001 and p = 0.003, respectively). By multivariable analysis, Pringle's maneuver duration [odds ratio 1.049, 95% confidence interval (CI) 1.001–1.098; p = 0.043] was significantly associated with increased UL-VWFMs level after hepatectomy. UL-VWFMs index was significantly correlated with Pringle's maneuver duration (r = 0.444, p = 0.017). ConclusionsPlasma UL-VWFMs levels increased after hepatectomy due to ischaemia–reperfusion injury with Pringle's maneuver.</description><subject>ADAMTS13</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Hematology, Oncology, and Palliative Medicine</subject><subject>Hepatectomy</subject><subject>Hepatectomy - adverse effects</subject><subject>Hepatectomy - methods</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Reperfusion Injury - complications</subject><subject>Unusually large VWF multimers</subject><subject>von Willebrand Factor - metabolism</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks-KFDEQxoMo7rj6CktueumxkvSf5CLK4p-FBQUVjyGdrt5Jm-4ek85I3_YdfEOfxAyz68GLUFCH-r4qvh9FyAWDLQNWvxy2yy7MY8C45cDUFnJB9YBsmGxUwcuGPyQbgFIVQpbyjDyJcQBgDVPVY3ImWMWkqmFDbq-i3Rkcnfl9-yvgHkOfopsn6qYhhZX-dMuOfgpuuvH4PNLRTJgOGPK4SxYjTVOKyXi_Um_CDdJDtn5z3mMbzNTR3thlDnRMfnEjhkhNv2T3DvdmwTwa16fkUW98xGd3_Zx8fff2y-WH4vrj-6vLN9eFrZRaioZx1nQINauhkS23pex4LWTfml5K6BrbqZo1FZYtguRClZUUneWit1bynotz8uK0dx_mHwnjokcXLXqfE80pas4VSNFIKLO0PkltmGMM2Ot9cKMJq2agj_T1oO_p6yN9DbmgysaLuxupHbH7a7vHnQWvTwLMSQ8Og47W4WSxcyHj0N3s_n_j1T8rrHeTs8Z_xxXjMKcwZY6a6cg16M_HHzi-AFMCSmBC_AGmurLx</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Yoshikawa, Takahiro</creator><creator>Nomi, Takeo</creator><creator>Sakai, Kazuya</creator><creator>Hayakawa, Masaki</creator><creator>Hokuto, Daisuke</creator><creator>Matsuo, Yasuko</creator><creator>Sho, Masayuki</creator><creator>Matsumoto, Masanori</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7243-3126</orcidid><orcidid>https://orcid.org/0000-0003-0523-7931</orcidid></search><sort><creationdate>20191101</creationdate><title>Ischaemia–reperfusion injury with Pringle's maneuver induces unusually large von Willebrand factor multimers after hepatectomy</title><author>Yoshikawa, Takahiro ; Nomi, Takeo ; Sakai, Kazuya ; Hayakawa, Masaki ; Hokuto, Daisuke ; Matsuo, Yasuko ; Sho, Masayuki ; Matsumoto, Masanori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c599t-71217de0616078b2c48d2638fbaf880d7cd96175e4be082394583dc23fcc82f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>ADAMTS13</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Hematology, Oncology, and Palliative Medicine</topic><topic>Hepatectomy</topic><topic>Hepatectomy - adverse effects</topic><topic>Hepatectomy - methods</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Reperfusion Injury - complications</topic><topic>Unusually large VWF multimers</topic><topic>von Willebrand Factor - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshikawa, Takahiro</creatorcontrib><creatorcontrib>Nomi, Takeo</creatorcontrib><creatorcontrib>Sakai, Kazuya</creatorcontrib><creatorcontrib>Hayakawa, Masaki</creatorcontrib><creatorcontrib>Hokuto, Daisuke</creatorcontrib><creatorcontrib>Matsuo, Yasuko</creatorcontrib><creatorcontrib>Sho, Masayuki</creatorcontrib><creatorcontrib>Matsumoto, Masanori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshikawa, Takahiro</au><au>Nomi, Takeo</au><au>Sakai, Kazuya</au><au>Hayakawa, Masaki</au><au>Hokuto, Daisuke</au><au>Matsuo, Yasuko</au><au>Sho, Masayuki</au><au>Matsumoto, Masanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ischaemia–reperfusion injury with Pringle's maneuver induces unusually large von Willebrand factor multimers after hepatectomy</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>183</volume><spage>20</spage><epage>27</epage><pages>20-27</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><abstract>AbstractIntroductionvon Willebrand factor (VWF) is synthesised in vascular endothelial cells and released into the plasma as unusually large VWF multimers (UL-VWFMs). Sinusoidal endothelial cells are a major target of ischaemia–reperfusion injury due to liver surgery. This study aimed to clarify the effect of hepatectomy on UL-VWFMs. Materials and methodsThirty-five patients who underwent hepatectomy were eligible for the study. Plasma ADAMTS13 activity and VWF antigen levels were measured by enzyme-linked immunosorbent assay and multimer analysis of plasma VWF was performed according to Ruggeri and Zimmerman's method. For analyses, patients were categorised according to UL-VWFM positivity after hepatectomy. ResultsPlasma ADAMTS13 activity significantly decreased from 61.0% (27.7%–126.2%) before operation to 37.4% (20.2%–71.4%) on postoperative day 7 ( p < 0.001). Plasma VWF antigen levels significantly increased from 172.1% (80.5%–412.8%) before operation to 361.0% (154.7%–745.8%) on postoperative day 2, which remained high until postoperative day 7 ( p < 0.001). Seven patients remained UL-VWFMs-negative and 22 patients became UL-VWFMs-positive after operation. Pringle's maneuver duration was significantly longer and blood loss volume was significantly higher in the UL-VWFMs-positive group ( p = 0.001 and p = 0.003, respectively). By multivariable analysis, Pringle's maneuver duration [odds ratio 1.049, 95% confidence interval (CI) 1.001–1.098; p = 0.043] was significantly associated with increased UL-VWFMs level after hepatectomy. UL-VWFMs index was significantly correlated with Pringle's maneuver duration (r = 0.444, p = 0.017). ConclusionsPlasma UL-VWFMs levels increased after hepatectomy due to ischaemia–reperfusion injury with Pringle's maneuver.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>31518960</pmid><doi>10.1016/j.thromres.2019.09.005</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7243-3126</orcidid><orcidid>https://orcid.org/0000-0003-0523-7931</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | ADAMTS13 Aged Aged, 80 and over Cohort Studies Female Hematology, Oncology, and Palliative Medicine Hepatectomy Hepatectomy - adverse effects Hepatectomy - methods Humans Male Middle Aged Prospective Studies Reperfusion Injury - complications Unusually large VWF multimers von Willebrand Factor - metabolism |
| title | Ischaemia–reperfusion injury with Pringle's maneuver induces unusually large von Willebrand factor multimers after hepatectomy |
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