The effect of quercetin on iron overload and inflammation in β-thalassemia major patients: A double-blind randomized clinical trial

•42 patients received a 500 mg/day quercetin and 42 others took a 500 mg/day placebo for 12 w.•Quercetin could significantly reduce ferritin and other serum iron factors (P > 0.05).•Quercetin significantly reduced hs-CRP (P = 0.046), but not TNF-α (p = 0.310).•According to our results, quercetin...

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Veröffentlicht in:	Complementary therapies in medicine 2019-10, Vol.46, p.24-28
Hauptverfasser:	Sajadi Hezaveh, Zohreh, Azarkeivan, Azita, Janani, Leila, Hosseini, Sharieh, Shidfar, Farzad
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Anthropometry beta-Thalassemia - drug therapy beta-Thalassemia - metabolism Binding sites Blood transfusions C-reactive protein C-Reactive Protein - metabolism Chelation therapy Clinical trial Clinical trials Demographics Diabetes Diet Disease Double-Blind Method Double-blind studies Evidence-based medicine Female Ferritin Ferritins - metabolism Hemoglobin Humans Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Iron Iron - adverse effects Iron - therapeutic use Iron Overload - chemically induced Iron Overload - drug therapy Iron Overload - metabolism Liver Male Metabolism Pediatrics Quercetin Quercetin - therapeutic use Research centers Starch Thalassemia Thalassemia major Transferrin Transferrin - metabolism Transferrins Tumor necrosis factor-α
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