MicroRNA-27a alleviates IL-1β-induced inflammatory response and articular cartilage degradation via TLR4/NF-κB signaling pathway in articular chondrocytes

Osteoarthritis (OA) is a common disease of the articular cartilage, and inflammatory response and articular cartilage degradation have been implicated in the pathogenesis of OA. In recent years, microRNAs (miRNAs) have been potentially involved in the pathogenesis of OA. However, little is known abo...

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Veröffentlicht in:	International immunopharmacology 2019-11, Vol.76, p.105839-105839, Article 105839
Hauptverfasser:	Qiu, Wen-Jun, Xu, Ming-Ze, Zhu, Xiao-dong, Ji, Yun-Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Articular cartilage degradation Biomedical materials Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - immunology Cells, Cultured Chondrocytes Chondrocytes - immunology Cytokines Degeneration Degradation Humans IL-1β Inflammation Inflammation - immunology Inflammatory response Interleukin 8 Interleukin-1beta - immunology MicroRNA-27a MicroRNAs MicroRNAs - immunology Middle Aged miRNA NF-kappa B - immunology NF-κB protein Osteoarthritis Osteoarthritis - immunology Pathogenesis Reactive oxygen species Reactive Oxygen Species - immunology Ribonucleic acid RNA Signal Transduction Signaling Target recognition Therapeutic applications TLR4 protein TLR4/NF-κB signaling pathway Toll-Like Receptor 4 - immunology Toll-like receptors Tumor necrosis factor-TNF Tumor necrosis factor-α
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