Hepatocyte Stress Increases Expression of Yes‐Associated Protein and Transcriptional Coactivator With PDZ‐Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis

Background and Aims Activated hepatocytes are hypothesized to be a major source of signals that drive cirrhosis, but the biochemical pathways that convert hepatocytes into such a state are unclear. We examined the role of the Hippo pathway transcriptional coactivators Yes‐associated protein (YAP) an...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2020-05, Vol.71 (5), p.1813-1830
Hauptverfasser:	Mooring, Meghan, Fowl, Brendan H., Lum, Shelly Z.C., Liu, Ye, Yao, Kangning, Softic, Samir, Kirchner, Rory, Bernstein, Aaron, Singhi, Aatur D., Jay, Daniel G., Kahn, C. Ronald, Camargo, Fernando D., Yimlamai, Dean
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animal models Animals Carbon tetrachloride CCL4 protein Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell interactions Chemokines Cirrhosis Collagen (type I) CYR61 protein Cysteine-Rich Protein 61 - genetics Cysteine-Rich Protein 61 - metabolism Disease Models, Animal Fibrosis Gain of Function Mutation Growth factors Hepatocytes Hepatocytes - metabolism Hepatology Humans Inflammation Liver Liver cirrhosis Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Loss of Function Mutation Macrophages Metalloproteinase Mice Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Stress, Physiological Tissue inhibitor of metalloproteinase 1 Trans-Activators - genetics Trans-Activators - metabolism Transcription Transcription Factors - genetics Transcription Factors - metabolism Yes-associated protein
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