Association Between Alcohol Consumption and Risk of Nasopharyngeal Carcinoma: A Comprehensive Meta‐Analysis of Epidemiological Studies
Background Alcohol consumption is increasing all over the world, but whether it is an independent factor affecting the occurrence of nasopharyngeal carcinoma (NPC) is inconsistent in many studies. We aimed to explore the association between alcohol consumption and NPC risk by integrating existing ev...
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| Veröffentlicht in: | Alcoholism, clinical and experimental research clinical and experimental research, 2019-11, Vol.43 (11), p.2262-2273 |
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| container_title | Alcoholism, clinical and experimental research |
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| creator | Du, Taifeng Chen, Kangkang Zheng, Shukai Bao, Mian Huang, Yuanni Wu, Kusheng |
| description | Background
Alcohol consumption is increasing all over the world, but whether it is an independent factor affecting the occurrence of nasopharyngeal carcinoma (NPC) is inconsistent in many studies. We aimed to explore the association between alcohol consumption and NPC risk by integrating existing evidence in a meta‐analysis.
Methods
We searched for relevant articles published up to August 2018 in PubMed, Cochrane Library, Web of Science, and China National Knowledge infrastructure (CNKI). The Newcastle–Ottawa scale was used to assess the quality of the included studies. Odds ratios (ORs) or relative risks were pooled to estimate the associations between alcohol consumption and NPC risk.
Results
The meta‐analysis of cohort studies showed no significant association between alcohol consumption and NPC, but pooled results from case–control studies indicated that ever drinking increased the probability of NPC versus nondrinking (OR = 1.10; 95% confidence interval [CI]: 1.01, 1.19). As compared with nondrinkers, high‐frequency drinking (≥7 times/wk) increased the NPC probability (OR = 1.29; 95% CI: 1.05, 1.53) and low‐frequency drinking ( |
| doi_str_mv | 10.1111/acer.14184 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2288741789</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2310957953</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3574-68f5544d9d7fe8ef2c6f85596de1f4770ffd79f2040a9ba4d08ffd5a9f5be88d3</originalsourceid><addsrcrecordid>eNp90UFvFCEYBmBiNHZbvfgDzCRejMlUmIEBvI2b1TapmlQ9T1j46FJnYAozNnvr0aO_sb-kbLd68CAXEni-N4EXoRcEH5O83ioN8ZhQIugjtCCsxiWuOH-MFphQVjYYiwN0mNIlxpiKpnmKDmpC60Y0coF-tSkF7dTkgi_ew3QN4Iu212ET-mIZfJqH8f5OeVOcu_SjCLb4rFIYNypu_QWozFTUzodBvSvaPDOMETbgk_sJxSeY1O3N79arfptc2g2vRmdgcKEPF07n6a_TbBykZ-iJVX2C5w_7Efr-YfVteVKeffl4umzPSl0zTstGWMYoNdJwCwJspRsrGJONAWIp59haw6WtMMVKrhU1WOQTpqRlaxDC1Efo9T53jOFqhjR1g0sa-l55CHPqqkoITgkXMtNX_9DLMMf8lKxqgiXjktVZvdkrHUNKEWw3Rjfkz-kI7nb9dLt-uvt-Mn75EDmvBzB_6Z9CMiB7cO162P4nqmuXq_N96B1syJ3L</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2310957953</pqid></control><display><type>article</type><title>Association Between Alcohol Consumption and Risk of Nasopharyngeal Carcinoma: A Comprehensive Meta‐Analysis of Epidemiological Studies</title><source>Access via Wiley Online Library</source><creator>Du, Taifeng ; Chen, Kangkang ; Zheng, Shukai ; Bao, Mian ; Huang, Yuanni ; Wu, Kusheng</creator><creatorcontrib>Du, Taifeng ; Chen, Kangkang ; Zheng, Shukai ; Bao, Mian ; Huang, Yuanni ; Wu, Kusheng</creatorcontrib><description>Background
Alcohol consumption is increasing all over the world, but whether it is an independent factor affecting the occurrence of nasopharyngeal carcinoma (NPC) is inconsistent in many studies. We aimed to explore the association between alcohol consumption and NPC risk by integrating existing evidence in a meta‐analysis.
Methods
We searched for relevant articles published up to August 2018 in PubMed, Cochrane Library, Web of Science, and China National Knowledge infrastructure (CNKI). The Newcastle–Ottawa scale was used to assess the quality of the included studies. Odds ratios (ORs) or relative risks were pooled to estimate the associations between alcohol consumption and NPC risk.
Results
The meta‐analysis of cohort studies showed no significant association between alcohol consumption and NPC, but pooled results from case–control studies indicated that ever drinking increased the probability of NPC versus nondrinking (OR = 1.10; 95% confidence interval [CI]: 1.01, 1.19). As compared with nondrinkers, high‐frequency drinking (≥7 times/wk) increased the NPC probability (OR = 1.29; 95% CI: 1.05, 1.53) and low‐frequency drinking (<7 times/wk) decreased the probability (OR = 0.77; 95% CI: 0.60, 0.94), as did shorter duration of drinking (<20 years) (OR = 0.64; 95% CI: 0.49, 0.79). On subgroup analyses, significant pooled results were observed for studies with high quality, with hospital‐based controls and with adjustment for confounding factors, smoking, age, and sex.
Conclusions
The risk of NPC may increase with alcohol consumption. Ever drinking increased the risk versus nondrinking. Additionally, high‐frequency drinking increased the risk, but low‐frequency drinking decreased it to some extent. Further intensive studies based on well‐designed methods are needed to examine the association.
Alcohol consumption is increasing worldwide, and there are many inconsistencies about the association between alcohol and the risk of NPC. Present study summarized all the existing evidence to explore the association between alcohol and NPC. The pooled results demonstrate that alcohol consumption may be positively associated with risk of NPC versus nondrinking. Additionally, high‐frequency drinking also increases the risk of NPC. Further intensive studies based on well‐designed schemes are needed to examine the association.</description><identifier>ISSN: 0145-6008</identifier><identifier>EISSN: 1530-0277</identifier><identifier>DOI: 10.1111/acer.14184</identifier><identifier>PMID: 31436869</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Alcohol ; Alcohol Consumption ; Alcohol use ; Alcohols ; Drinking ; Drinking behavior ; Epidemiology ; Health risk assessment ; Meta-analysis ; Nasopharyngeal Carcinoma ; Risk assessment ; Smoking ; Throat cancer</subject><ispartof>Alcoholism, clinical and experimental research, 2019-11, Vol.43 (11), p.2262-2273</ispartof><rights>2019 by the Research Society on Alcoholism</rights><rights>2019 by the Research Society on Alcoholism.</rights><rights>2019 Research Society on Alcoholism</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3574-68f5544d9d7fe8ef2c6f85596de1f4770ffd79f2040a9ba4d08ffd5a9f5be88d3</citedby><cites>FETCH-LOGICAL-c3574-68f5544d9d7fe8ef2c6f85596de1f4770ffd79f2040a9ba4d08ffd5a9f5be88d3</cites><orcidid>0000-0001-5163-2524 ; 0000-0002-0783-6092</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Facer.14184$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Facer.14184$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31436869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Taifeng</creatorcontrib><creatorcontrib>Chen, Kangkang</creatorcontrib><creatorcontrib>Zheng, Shukai</creatorcontrib><creatorcontrib>Bao, Mian</creatorcontrib><creatorcontrib>Huang, Yuanni</creatorcontrib><creatorcontrib>Wu, Kusheng</creatorcontrib><title>Association Between Alcohol Consumption and Risk of Nasopharyngeal Carcinoma: A Comprehensive Meta‐Analysis of Epidemiological Studies</title><title>Alcoholism, clinical and experimental research</title><addtitle>Alcohol Clin Exp Res</addtitle><description>Background
Alcohol consumption is increasing all over the world, but whether it is an independent factor affecting the occurrence of nasopharyngeal carcinoma (NPC) is inconsistent in many studies. We aimed to explore the association between alcohol consumption and NPC risk by integrating existing evidence in a meta‐analysis.
Methods
We searched for relevant articles published up to August 2018 in PubMed, Cochrane Library, Web of Science, and China National Knowledge infrastructure (CNKI). The Newcastle–Ottawa scale was used to assess the quality of the included studies. Odds ratios (ORs) or relative risks were pooled to estimate the associations between alcohol consumption and NPC risk.
Results
The meta‐analysis of cohort studies showed no significant association between alcohol consumption and NPC, but pooled results from case–control studies indicated that ever drinking increased the probability of NPC versus nondrinking (OR = 1.10; 95% confidence interval [CI]: 1.01, 1.19). As compared with nondrinkers, high‐frequency drinking (≥7 times/wk) increased the NPC probability (OR = 1.29; 95% CI: 1.05, 1.53) and low‐frequency drinking (<7 times/wk) decreased the probability (OR = 0.77; 95% CI: 0.60, 0.94), as did shorter duration of drinking (<20 years) (OR = 0.64; 95% CI: 0.49, 0.79). On subgroup analyses, significant pooled results were observed for studies with high quality, with hospital‐based controls and with adjustment for confounding factors, smoking, age, and sex.
Conclusions
The risk of NPC may increase with alcohol consumption. Ever drinking increased the risk versus nondrinking. Additionally, high‐frequency drinking increased the risk, but low‐frequency drinking decreased it to some extent. Further intensive studies based on well‐designed methods are needed to examine the association.
Alcohol consumption is increasing worldwide, and there are many inconsistencies about the association between alcohol and the risk of NPC. Present study summarized all the existing evidence to explore the association between alcohol and NPC. The pooled results demonstrate that alcohol consumption may be positively associated with risk of NPC versus nondrinking. Additionally, high‐frequency drinking also increases the risk of NPC. Further intensive studies based on well‐designed schemes are needed to examine the association.</description><subject>Alcohol</subject><subject>Alcohol Consumption</subject><subject>Alcohol use</subject><subject>Alcohols</subject><subject>Drinking</subject><subject>Drinking behavior</subject><subject>Epidemiology</subject><subject>Health risk assessment</subject><subject>Meta-analysis</subject><subject>Nasopharyngeal Carcinoma</subject><subject>Risk assessment</subject><subject>Smoking</subject><subject>Throat cancer</subject><issn>0145-6008</issn><issn>1530-0277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp90UFvFCEYBmBiNHZbvfgDzCRejMlUmIEBvI2b1TapmlQ9T1j46FJnYAozNnvr0aO_sb-kbLd68CAXEni-N4EXoRcEH5O83ioN8ZhQIugjtCCsxiWuOH-MFphQVjYYiwN0mNIlxpiKpnmKDmpC60Y0coF-tSkF7dTkgi_ew3QN4Iu212ET-mIZfJqH8f5OeVOcu_SjCLb4rFIYNypu_QWozFTUzodBvSvaPDOMETbgk_sJxSeY1O3N79arfptc2g2vRmdgcKEPF07n6a_TbBykZ-iJVX2C5w_7Efr-YfVteVKeffl4umzPSl0zTstGWMYoNdJwCwJspRsrGJONAWIp59haw6WtMMVKrhU1WOQTpqRlaxDC1Efo9T53jOFqhjR1g0sa-l55CHPqqkoITgkXMtNX_9DLMMf8lKxqgiXjktVZvdkrHUNKEWw3Rjfkz-kI7nb9dLt-uvt-Mn75EDmvBzB_6Z9CMiB7cO162P4nqmuXq_N96B1syJ3L</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Du, Taifeng</creator><creator>Chen, Kangkang</creator><creator>Zheng, Shukai</creator><creator>Bao, Mian</creator><creator>Huang, Yuanni</creator><creator>Wu, Kusheng</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K7.</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5163-2524</orcidid><orcidid>https://orcid.org/0000-0002-0783-6092</orcidid></search><sort><creationdate>201911</creationdate><title>Association Between Alcohol Consumption and Risk of Nasopharyngeal Carcinoma: A Comprehensive Meta‐Analysis of Epidemiological Studies</title><author>Du, Taifeng ; Chen, Kangkang ; Zheng, Shukai ; Bao, Mian ; Huang, Yuanni ; Wu, Kusheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3574-68f5544d9d7fe8ef2c6f85596de1f4770ffd79f2040a9ba4d08ffd5a9f5be88d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alcohol</topic><topic>Alcohol Consumption</topic><topic>Alcohol use</topic><topic>Alcohols</topic><topic>Drinking</topic><topic>Drinking behavior</topic><topic>Epidemiology</topic><topic>Health risk assessment</topic><topic>Meta-analysis</topic><topic>Nasopharyngeal Carcinoma</topic><topic>Risk assessment</topic><topic>Smoking</topic><topic>Throat cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Taifeng</creatorcontrib><creatorcontrib>Chen, Kangkang</creatorcontrib><creatorcontrib>Zheng, Shukai</creatorcontrib><creatorcontrib>Bao, Mian</creatorcontrib><creatorcontrib>Huang, Yuanni</creatorcontrib><creatorcontrib>Wu, Kusheng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Alcoholism, clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Taifeng</au><au>Chen, Kangkang</au><au>Zheng, Shukai</au><au>Bao, Mian</au><au>Huang, Yuanni</au><au>Wu, Kusheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Alcohol Consumption and Risk of Nasopharyngeal Carcinoma: A Comprehensive Meta‐Analysis of Epidemiological Studies</atitle><jtitle>Alcoholism, clinical and experimental research</jtitle><addtitle>Alcohol Clin Exp Res</addtitle><date>2019-11</date><risdate>2019</risdate><volume>43</volume><issue>11</issue><spage>2262</spage><epage>2273</epage><pages>2262-2273</pages><issn>0145-6008</issn><eissn>1530-0277</eissn><abstract>Background
Alcohol consumption is increasing all over the world, but whether it is an independent factor affecting the occurrence of nasopharyngeal carcinoma (NPC) is inconsistent in many studies. We aimed to explore the association between alcohol consumption and NPC risk by integrating existing evidence in a meta‐analysis.
Methods
We searched for relevant articles published up to August 2018 in PubMed, Cochrane Library, Web of Science, and China National Knowledge infrastructure (CNKI). The Newcastle–Ottawa scale was used to assess the quality of the included studies. Odds ratios (ORs) or relative risks were pooled to estimate the associations between alcohol consumption and NPC risk.
Results
The meta‐analysis of cohort studies showed no significant association between alcohol consumption and NPC, but pooled results from case–control studies indicated that ever drinking increased the probability of NPC versus nondrinking (OR = 1.10; 95% confidence interval [CI]: 1.01, 1.19). As compared with nondrinkers, high‐frequency drinking (≥7 times/wk) increased the NPC probability (OR = 1.29; 95% CI: 1.05, 1.53) and low‐frequency drinking (<7 times/wk) decreased the probability (OR = 0.77; 95% CI: 0.60, 0.94), as did shorter duration of drinking (<20 years) (OR = 0.64; 95% CI: 0.49, 0.79). On subgroup analyses, significant pooled results were observed for studies with high quality, with hospital‐based controls and with adjustment for confounding factors, smoking, age, and sex.
Conclusions
The risk of NPC may increase with alcohol consumption. Ever drinking increased the risk versus nondrinking. Additionally, high‐frequency drinking increased the risk, but low‐frequency drinking decreased it to some extent. Further intensive studies based on well‐designed methods are needed to examine the association.
Alcohol consumption is increasing worldwide, and there are many inconsistencies about the association between alcohol and the risk of NPC. Present study summarized all the existing evidence to explore the association between alcohol and NPC. The pooled results demonstrate that alcohol consumption may be positively associated with risk of NPC versus nondrinking. Additionally, high‐frequency drinking also increases the risk of NPC. Further intensive studies based on well‐designed schemes are needed to examine the association.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31436869</pmid><doi>10.1111/acer.14184</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5163-2524</orcidid><orcidid>https://orcid.org/0000-0002-0783-6092</orcidid></addata></record> |
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| source | Access via Wiley Online Library |
| subjects | Alcohol Alcohol Consumption Alcohol use Alcohols Drinking Drinking behavior Epidemiology Health risk assessment Meta-analysis Nasopharyngeal Carcinoma Risk assessment Smoking Throat cancer |
| title | Association Between Alcohol Consumption and Risk of Nasopharyngeal Carcinoma: A Comprehensive Meta‐Analysis of Epidemiological Studies |
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