Oxidized low-density lipoproteins induce tissue factor expression in T-lymphocytes via activation of lectin-like oxidized low-density lipoprotein receptor-1

Abstract Aims T-lymphocytes plays an important role in the pathophysiology of acute coronary syndromes. T-cell activation in vitro by pro-inflammatory cytokines may lead to functional tissue factor (TF) expression, indicating a possible contribution of immunity to thrombosis. Oxidized low-density li...

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Veröffentlicht in:	Cardiovascular research 2020-05, Vol.116 (6), p.1125-1135
Hauptverfasser:	Cimmino, Giovanni, Cirillo, Plinio, Conte, Stefano, Pellegrino, Grazia, Barra, Giusi, Maresca, Lucio, Morello, Andrea, Calì, Gaetano, Loffredo, Francesco, De Palma, Raffaele, Arena, Giulia, Sawamura, Tatsuya, Ambrosio, Giuseppe, Golino, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Carotid Artery Diseases - genetics Carotid Artery Diseases - metabolism Carotid Artery Diseases - pathology Cells, Cultured Humans Lipoproteins, LDL - pharmacology NADPH Oxidases - metabolism NF-kappa B - metabolism Plaque, Atherosclerotic Reactive Oxygen Species - metabolism Scavenger Receptors, Class E - agonists Scavenger Receptors, Class E - genetics Scavenger Receptors, Class E - metabolism T-Lymphocytes - drug effects T-Lymphocytes - metabolism Thromboplastin - genetics Thromboplastin - metabolism Up-Regulation
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