Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial Partial-Thickness Wounds: A Pilot Study
Abstract This study aims to evaluate the efficacy of Nile tilapia skin as a xenograft for the treatment of partial-thickness burn wounds in children. This is an open-label, monocentric, randomized phase II pilot study conducted in Fortaleza, Brazil. The study population consisted of 30 children betw...
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Veröffentlicht in: | Journal of burn care & research 2020-02, Vol.41 (2), p.241-247 |
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creator | Lima Júnior, Edmar Maciel Moraes Filho, Manoel Odorico de Forte, Antonio Jorge Costa, Bruno Almeida Fechine, Francisco Vagnaldo Alves, Ana Paula Negreiros Nunes Moraes, Maria Elisabete Amaral de Rocha, Marina Becker Sales Silva Júnior, Francisco Raimundo Soares, Maria Flaviane Araújo do Nascimento Bezerra, Alane Nogueira Martins, Camila Barroso Mathor, Mônica Beatriz |
description | Abstract
This study aims to evaluate the efficacy of Nile tilapia skin as a xenograft for the treatment of partial-thickness burn wounds in children. This is an open-label, monocentric, randomized phase II pilot study conducted in Fortaleza, Brazil. The study population consisted of 30 children between the ages of 2 and 12 years with superficial “partial-thickness” burns admitted less than 72 hours from the thermal injury. In the test group, the tilapia skin was applied. In the control group, a thin layer of silver sulfadiazine cream 1% was applied. Tilapia skin showed good adherence to the wound bed, reducing the number of dressing changes required, the amount of anesthetics used, and providing benefits for the patients and also for healthcare professionals, by reducing the overall work load. The number of days to complete burn wound healing, the total amount of analgesics required throughout the treatment, burn improvement on the day of dressing removal, and pain throughout the treatment were similar to the conventional treatment with silver sulfadiazine. Thus, tilapia skin can be considered an effective and low-cost extra resource in the therapeutic arsenal of pediatric superficial partial thickness burns. |
doi_str_mv | 10.1093/jbcr/irz149 |
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This study aims to evaluate the efficacy of Nile tilapia skin as a xenograft for the treatment of partial-thickness burn wounds in children. This is an open-label, monocentric, randomized phase II pilot study conducted in Fortaleza, Brazil. The study population consisted of 30 children between the ages of 2 and 12 years with superficial “partial-thickness” burns admitted less than 72 hours from the thermal injury. In the test group, the tilapia skin was applied. In the control group, a thin layer of silver sulfadiazine cream 1% was applied. Tilapia skin showed good adherence to the wound bed, reducing the number of dressing changes required, the amount of anesthetics used, and providing benefits for the patients and also for healthcare professionals, by reducing the overall work load. The number of days to complete burn wound healing, the total amount of analgesics required throughout the treatment, burn improvement on the day of dressing removal, and pain throughout the treatment were similar to the conventional treatment with silver sulfadiazine. Thus, tilapia skin can be considered an effective and low-cost extra resource in the therapeutic arsenal of pediatric superficial partial thickness burns.</description><identifier>ISSN: 1559-047X</identifier><identifier>EISSN: 1559-0488</identifier><identifier>DOI: 10.1093/jbcr/irz149</identifier><identifier>PMID: 31504615</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><ispartof>Journal of burn care & research, 2020-02, Vol.41 (2), p.241-247</ispartof><rights>American Burn Association 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2019</rights><rights>American Burn Association 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-4846b5e9e01688a74315cce867ef1ef66b7529bf32081fd6bdf68d25ced851dd3</citedby><cites>FETCH-LOGICAL-c320t-4846b5e9e01688a74315cce867ef1ef66b7529bf32081fd6bdf68d25ced851dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1581,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31504615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lima Júnior, Edmar Maciel</creatorcontrib><creatorcontrib>Moraes Filho, Manoel Odorico de</creatorcontrib><creatorcontrib>Forte, Antonio Jorge</creatorcontrib><creatorcontrib>Costa, Bruno Almeida</creatorcontrib><creatorcontrib>Fechine, Francisco Vagnaldo</creatorcontrib><creatorcontrib>Alves, Ana Paula Negreiros Nunes</creatorcontrib><creatorcontrib>Moraes, Maria Elisabete Amaral de</creatorcontrib><creatorcontrib>Rocha, Marina Becker Sales</creatorcontrib><creatorcontrib>Silva Júnior, Francisco Raimundo</creatorcontrib><creatorcontrib>Soares, Maria Flaviane Araújo do Nascimento</creatorcontrib><creatorcontrib>Bezerra, Alane Nogueira</creatorcontrib><creatorcontrib>Martins, Camila Barroso</creatorcontrib><creatorcontrib>Mathor, Mônica Beatriz</creatorcontrib><title>Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial Partial-Thickness Wounds: A Pilot Study</title><title>Journal of burn care & research</title><addtitle>J Burn Care Res</addtitle><description>Abstract
This study aims to evaluate the efficacy of Nile tilapia skin as a xenograft for the treatment of partial-thickness burn wounds in children. This is an open-label, monocentric, randomized phase II pilot study conducted in Fortaleza, Brazil. The study population consisted of 30 children between the ages of 2 and 12 years with superficial “partial-thickness” burns admitted less than 72 hours from the thermal injury. In the test group, the tilapia skin was applied. In the control group, a thin layer of silver sulfadiazine cream 1% was applied. Tilapia skin showed good adherence to the wound bed, reducing the number of dressing changes required, the amount of anesthetics used, and providing benefits for the patients and also for healthcare professionals, by reducing the overall work load. The number of days to complete burn wound healing, the total amount of analgesics required throughout the treatment, burn improvement on the day of dressing removal, and pain throughout the treatment were similar to the conventional treatment with silver sulfadiazine. Thus, tilapia skin can be considered an effective and low-cost extra resource in the therapeutic arsenal of pediatric superficial partial thickness burns.</description><issn>1559-047X</issn><issn>1559-0488</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAURoMoOo6u3EtWIkidpG3a1J2KLxhwYDo4u5ImN5qZvkzShf56K1WXrr67OBwuB6ETSi4pyaLZppR2ZuwnjbMdNKGMZQGJOd_9u9P1ATp0bkNIHJOU7aODiDISJ5RNkF2AMsJbI_FNbxucWxC-hsbjlTPNK85NJToj8HJrGiwcFngNTftqhfZYtxYv-w6sNtKICi-E9cMG-ZuR2wacwy9t3yh3ha_xwlStx0vfq48jtKdF5eD4Z6dodX-X3z4G8-eHp9vreSCjkPgg5nFSMsiA0IRzkcbD01ICT1LQFHSSlCkLs1IPMKdaJaXSCVchk6A4o0pFU3Q-ejvbvvfgfFEbJ6GqRANt74ow5DwNQxqlA3oxotK2zlnQRWdNLexHQUnxHbn4jlyMkQf69EfclzWoP_a36gCcjUDbd_-avgC_Tocm</recordid><startdate>20200219</startdate><enddate>20200219</enddate><creator>Lima Júnior, Edmar Maciel</creator><creator>Moraes Filho, Manoel Odorico de</creator><creator>Forte, Antonio Jorge</creator><creator>Costa, Bruno Almeida</creator><creator>Fechine, Francisco Vagnaldo</creator><creator>Alves, Ana Paula Negreiros Nunes</creator><creator>Moraes, Maria Elisabete Amaral de</creator><creator>Rocha, Marina Becker Sales</creator><creator>Silva Júnior, Francisco Raimundo</creator><creator>Soares, Maria Flaviane Araújo do Nascimento</creator><creator>Bezerra, Alane Nogueira</creator><creator>Martins, Camila Barroso</creator><creator>Mathor, Mônica Beatriz</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200219</creationdate><title>Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial Partial-Thickness Wounds: A Pilot Study</title><author>Lima Júnior, Edmar Maciel ; Moraes Filho, Manoel Odorico de ; Forte, Antonio Jorge ; Costa, Bruno Almeida ; Fechine, Francisco Vagnaldo ; Alves, Ana Paula Negreiros Nunes ; Moraes, Maria Elisabete Amaral de ; Rocha, Marina Becker Sales ; Silva Júnior, Francisco Raimundo ; Soares, Maria Flaviane Araújo do Nascimento ; Bezerra, Alane Nogueira ; Martins, Camila Barroso ; Mathor, Mônica Beatriz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-4846b5e9e01688a74315cce867ef1ef66b7529bf32081fd6bdf68d25ced851dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lima Júnior, Edmar Maciel</creatorcontrib><creatorcontrib>Moraes Filho, Manoel Odorico de</creatorcontrib><creatorcontrib>Forte, Antonio Jorge</creatorcontrib><creatorcontrib>Costa, Bruno Almeida</creatorcontrib><creatorcontrib>Fechine, Francisco Vagnaldo</creatorcontrib><creatorcontrib>Alves, Ana Paula Negreiros Nunes</creatorcontrib><creatorcontrib>Moraes, Maria Elisabete Amaral de</creatorcontrib><creatorcontrib>Rocha, Marina Becker Sales</creatorcontrib><creatorcontrib>Silva Júnior, Francisco Raimundo</creatorcontrib><creatorcontrib>Soares, Maria Flaviane Araújo do Nascimento</creatorcontrib><creatorcontrib>Bezerra, Alane Nogueira</creatorcontrib><creatorcontrib>Martins, Camila Barroso</creatorcontrib><creatorcontrib>Mathor, Mônica Beatriz</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of burn care & research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lima Júnior, Edmar Maciel</au><au>Moraes Filho, Manoel Odorico de</au><au>Forte, Antonio Jorge</au><au>Costa, Bruno Almeida</au><au>Fechine, Francisco Vagnaldo</au><au>Alves, Ana Paula Negreiros Nunes</au><au>Moraes, Maria Elisabete Amaral de</au><au>Rocha, Marina Becker Sales</au><au>Silva Júnior, Francisco Raimundo</au><au>Soares, Maria Flaviane Araújo do Nascimento</au><au>Bezerra, Alane Nogueira</au><au>Martins, Camila Barroso</au><au>Mathor, Mônica Beatriz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial Partial-Thickness Wounds: A Pilot Study</atitle><jtitle>Journal of burn care & research</jtitle><addtitle>J Burn Care Res</addtitle><date>2020-02-19</date><risdate>2020</risdate><volume>41</volume><issue>2</issue><spage>241</spage><epage>247</epage><pages>241-247</pages><issn>1559-047X</issn><eissn>1559-0488</eissn><abstract>Abstract
This study aims to evaluate the efficacy of Nile tilapia skin as a xenograft for the treatment of partial-thickness burn wounds in children. This is an open-label, monocentric, randomized phase II pilot study conducted in Fortaleza, Brazil. The study population consisted of 30 children between the ages of 2 and 12 years with superficial “partial-thickness” burns admitted less than 72 hours from the thermal injury. In the test group, the tilapia skin was applied. In the control group, a thin layer of silver sulfadiazine cream 1% was applied. Tilapia skin showed good adherence to the wound bed, reducing the number of dressing changes required, the amount of anesthetics used, and providing benefits for the patients and also for healthcare professionals, by reducing the overall work load. The number of days to complete burn wound healing, the total amount of analgesics required throughout the treatment, burn improvement on the day of dressing removal, and pain throughout the treatment were similar to the conventional treatment with silver sulfadiazine. Thus, tilapia skin can be considered an effective and low-cost extra resource in the therapeutic arsenal of pediatric superficial partial thickness burns.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>31504615</pmid><doi>10.1093/jbcr/irz149</doi><tpages>7</tpages></addata></record> |
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title | Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial Partial-Thickness Wounds: A Pilot Study |
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