Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from Labisia pumila OA mitigation

Chondrosenescence (chondrocyte senescence) and subchondral bone deterioration in osteoarthritic rats were analyzed after treatment with the estrogenic herb Labisia pumila (LP) or diclofenac. Osteoarthritis (OA) was induced in bilaterally ovariectomized (OVX) rats by injecting mono-iodoacetate into t...

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Veröffentlicht in:	Journal of biosciences 2019-09, Vol.44 (4), p.1-11, Article 100
Hauptverfasser:	Madzuki, Iffah Nadhira, Lau, Seng Fong, Mohamad Shalan, Nor Aijratul Asikin, Mohd Ishak, Nur Iliyani, Mohamed, Suhaila
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - drug effects Aging - genetics Animals Biomarkers Biomedical and Life Sciences Biomedical materials Biomedicine Bone Development - drug effects Bone growth Bone histomorphometry Bone loss Bone resorption Bones Cancellous bone Cartilage Cartilage - drug effects Cartilage - metabolism Cartilage diseases Catabolism Cbfa-1 protein Cell Biology Chondrocytes Chondrocytes - drug effects Chondrocytes - metabolism Collagen Collagenase 3 Computed tomography Control Deterioration Diclofenac Diclofenac - pharmacology Disease Models, Animal Estrogen Receptor alpha - genetics Femur Flavonoids - pharmacology Gallic acid Gallic Acid - pharmacology Gene Expression Regulation - drug effects Histology Humans Hypoxia Iodoacetates - pharmacology Knee Life Sciences Matrix metalloproteinase Matrix Metalloproteinase 13 - genetics Matrix metalloproteinases Metabolism - drug effects Microbiology Mitigation mRNA Nonsteroidal anti-inflammatory drugs Osteoarthritis Osteoarthritis - drug therapy Osteoarthritis - genetics Osteoarthritis - pathology Osteogenesis Ovariectomy Overexpression Plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant Sciences Porosity Primulaceae - chemistry Rats Restoration Senescence Serum Subchondral bone Tomography Xenoestrogens Zoology
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