Adjuvant therapies in the management of medication‐related osteonecrosis of the jaws: Systematic review
Background We investigated the efficacy of hyperbaric oxygen (HBO), low‐intensity laser (LIL), and platelet‐rich plasma (PRP) in the management of medication‐related osteonecrosis of the jaws (MRONJ). Methods A literature search was conducted in accordance with the Preferred Reporting Items for Syst...
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| Veröffentlicht in: | Head & neck 2019-12, Vol.41 (12), p.4209-4228 |
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| container_title | Head & neck |
| container_volume | 41 |
| creator | Souza Tolentino, Elen Castro, Tamara F. Michellon, Felipe C. Passoni, Ana C. C. Ortega, Lorena J. A. Iwaki, Lilian C. V. Silva, Mariliani C. |
| description | Background
We investigated the efficacy of hyperbaric oxygen (HBO), low‐intensity laser (LIL), and platelet‐rich plasma (PRP) in the management of medication‐related osteonecrosis of the jaws (MRONJ).
Methods
A literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement. Two examiners independently assessed eligibility and risk of bias and extracted data.
Results
There was improvement in 75.6% of the 41 patients submitted to HBO, with positive effects on pain relief and decreased size and number of lesions at a faster rate, with better effects when the drug was discontinued. For LIL, 158 (64.2%) of the 246 patients/sites improved the symptoms and 98 (39.8%) healed completely. Fourteen (17.3%) of the 81 patients treated with PRP significantly improved the symptoms and 65 (80.2%) completely healed.
Conclusions
These therapies served as safe and effective adjuvant modalities for MRONJ treatment. The lack of randomized clinical trials evidences the need for more high‐quality investigations on the subject. |
| doi_str_mv | 10.1002/hed.25944 |
| format | Article |
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We investigated the efficacy of hyperbaric oxygen (HBO), low‐intensity laser (LIL), and platelet‐rich plasma (PRP) in the management of medication‐related osteonecrosis of the jaws (MRONJ).
Methods
A literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement. Two examiners independently assessed eligibility and risk of bias and extracted data.
Results
There was improvement in 75.6% of the 41 patients submitted to HBO, with positive effects on pain relief and decreased size and number of lesions at a faster rate, with better effects when the drug was discontinued. For LIL, 158 (64.2%) of the 246 patients/sites improved the symptoms and 98 (39.8%) healed completely. Fourteen (17.3%) of the 81 patients treated with PRP significantly improved the symptoms and 65 (80.2%) completely healed.
Conclusions
These therapies served as safe and effective adjuvant modalities for MRONJ treatment. The lack of randomized clinical trials evidences the need for more high‐quality investigations on the subject.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.25944</identifier><identifier>PMID: 31502752</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adjuvant therapy ; Clinical trials ; Head and neck ; Hyperbaric oxygen ; laser therapy ; medication‐related osteonecrosis of the jaw ; Osteonecrosis ; Patients ; platelet‐rich plasma</subject><ispartof>Head & neck, 2019-12, Vol.41 (12), p.4209-4228</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-a87aea70cc3e6b654546283dc2767f9ae269a7b01471406ff4691df03ca637753</citedby><cites>FETCH-LOGICAL-c3534-a87aea70cc3e6b654546283dc2767f9ae269a7b01471406ff4691df03ca637753</cites><orcidid>0000-0002-0394-9647</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.25944$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.25944$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31502752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Souza Tolentino, Elen</creatorcontrib><creatorcontrib>Castro, Tamara F.</creatorcontrib><creatorcontrib>Michellon, Felipe C.</creatorcontrib><creatorcontrib>Passoni, Ana C. C.</creatorcontrib><creatorcontrib>Ortega, Lorena J. A.</creatorcontrib><creatorcontrib>Iwaki, Lilian C. V.</creatorcontrib><creatorcontrib>Silva, Mariliani C.</creatorcontrib><title>Adjuvant therapies in the management of medication‐related osteonecrosis of the jaws: Systematic review</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
We investigated the efficacy of hyperbaric oxygen (HBO), low‐intensity laser (LIL), and platelet‐rich plasma (PRP) in the management of medication‐related osteonecrosis of the jaws (MRONJ).
Methods
A literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement. Two examiners independently assessed eligibility and risk of bias and extracted data.
Results
There was improvement in 75.6% of the 41 patients submitted to HBO, with positive effects on pain relief and decreased size and number of lesions at a faster rate, with better effects when the drug was discontinued. For LIL, 158 (64.2%) of the 246 patients/sites improved the symptoms and 98 (39.8%) healed completely. Fourteen (17.3%) of the 81 patients treated with PRP significantly improved the symptoms and 65 (80.2%) completely healed.
Conclusions
These therapies served as safe and effective adjuvant modalities for MRONJ treatment. The lack of randomized clinical trials evidences the need for more high‐quality investigations on the subject.</description><subject>Adjuvant therapy</subject><subject>Clinical trials</subject><subject>Head and neck</subject><subject>Hyperbaric oxygen</subject><subject>laser therapy</subject><subject>medication‐related osteonecrosis of the jaw</subject><subject>Osteonecrosis</subject><subject>Patients</subject><subject>platelet‐rich plasma</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kMlOwzAQhi0EYj_wAigSFzikjJfYDbeqrBISB-Bsuc6EuspS7KRVbzwCz8iTkFDggMTJY803v2Y-Qo4oDCgAO59iNmBJKsQG2aWQqhi4UJt9LXjMQYkdshfCDAC4FGyb7HCaAFMJ2yVulM3ahamaqJmiN3OHIXJV_4lKU5kXLLHr1XlUYuasaVxdfby9eyxMg1lUhwbrCq2vgws91c_NzDJcRI-rrld2AzbyuHC4PCBbuSkCHn6_--T5-uppfBvfP9zcjUf3seUJF7EZKoNGgbUc5UQmIhGSDXlmmZIqTw0ymRo1ASoUFSDzXMiUZjlwayRXKuH75HSdO_f1a4uh0aULFovCVFi3QTM2HAJlDHr05A86q1tfddtpxqmgknLRU2drqj8zeMz13LvS-JWmoHv_uvOvv_x37PF3YjvpjP2SP8I74HwNLF2Bq_-T9O3V5TryE_xGj5I</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Souza Tolentino, Elen</creator><creator>Castro, Tamara F.</creator><creator>Michellon, Felipe C.</creator><creator>Passoni, Ana C. C.</creator><creator>Ortega, Lorena J. A.</creator><creator>Iwaki, Lilian C. V.</creator><creator>Silva, Mariliani C.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0394-9647</orcidid></search><sort><creationdate>201912</creationdate><title>Adjuvant therapies in the management of medication‐related osteonecrosis of the jaws: Systematic review</title><author>Souza Tolentino, Elen ; Castro, Tamara F. ; Michellon, Felipe C. ; Passoni, Ana C. C. ; Ortega, Lorena J. A. ; Iwaki, Lilian C. V. ; Silva, Mariliani C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-a87aea70cc3e6b654546283dc2767f9ae269a7b01471406ff4691df03ca637753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adjuvant therapy</topic><topic>Clinical trials</topic><topic>Head and neck</topic><topic>Hyperbaric oxygen</topic><topic>laser therapy</topic><topic>medication‐related osteonecrosis of the jaw</topic><topic>Osteonecrosis</topic><topic>Patients</topic><topic>platelet‐rich plasma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Souza Tolentino, Elen</creatorcontrib><creatorcontrib>Castro, Tamara F.</creatorcontrib><creatorcontrib>Michellon, Felipe C.</creatorcontrib><creatorcontrib>Passoni, Ana C. C.</creatorcontrib><creatorcontrib>Ortega, Lorena J. A.</creatorcontrib><creatorcontrib>Iwaki, Lilian C. V.</creatorcontrib><creatorcontrib>Silva, Mariliani C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Souza Tolentino, Elen</au><au>Castro, Tamara F.</au><au>Michellon, Felipe C.</au><au>Passoni, Ana C. C.</au><au>Ortega, Lorena J. A.</au><au>Iwaki, Lilian C. V.</au><au>Silva, Mariliani C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adjuvant therapies in the management of medication‐related osteonecrosis of the jaws: Systematic review</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2019-12</date><risdate>2019</risdate><volume>41</volume><issue>12</issue><spage>4209</spage><epage>4228</epage><pages>4209-4228</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
We investigated the efficacy of hyperbaric oxygen (HBO), low‐intensity laser (LIL), and platelet‐rich plasma (PRP) in the management of medication‐related osteonecrosis of the jaws (MRONJ).
Methods
A literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement. Two examiners independently assessed eligibility and risk of bias and extracted data.
Results
There was improvement in 75.6% of the 41 patients submitted to HBO, with positive effects on pain relief and decreased size and number of lesions at a faster rate, with better effects when the drug was discontinued. For LIL, 158 (64.2%) of the 246 patients/sites improved the symptoms and 98 (39.8%) healed completely. Fourteen (17.3%) of the 81 patients treated with PRP significantly improved the symptoms and 65 (80.2%) completely healed.
Conclusions
These therapies served as safe and effective adjuvant modalities for MRONJ treatment. The lack of randomized clinical trials evidences the need for more high‐quality investigations on the subject.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31502752</pmid><doi>10.1002/hed.25944</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0002-0394-9647</orcidid></addata></record> |
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| subjects | Adjuvant therapy Clinical trials Head and neck Hyperbaric oxygen laser therapy medication‐related osteonecrosis of the jaw Osteonecrosis Patients platelet‐rich plasma |
| title | Adjuvant therapies in the management of medication‐related osteonecrosis of the jaws: Systematic review |
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