Formulation and characterization of a novel PHBV nanocomposite for bone defect filling and infection treatment

Biodegradable materials that combine bioactivity with sustained drug release have been proved promising for the treatment and prophylaxis of bone infection. In this work, injection-molded nanocomposites were formulated from poly(3-hydroxybutyrate-co-3-6%hydroxyvalerate) (PHBV), nanodiamond (nD) and...

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Veröffentlicht in:	Materials Science & Engineering C 2019-11, Vol.104, p.110004-110004, Article 110004
Hauptverfasser:	Almeida Neto, Gabriel Rodrigues de, Barcelos, Mariana Valinhos, Ribeiro, Maria Eduarda Araújo, Folly, Marcio Manhaes, Rodríguez, Rubén Jesus Sánchez
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Biodegradability Biodegradable materials Biodegradation Biological activity Biomaterial Bone and Bones - drug effects Bone Diseases - drug therapy Cell Line Cell Proliferation - drug effects Chemistry, Pharmaceutical - methods Controlled release Cytotoxicity Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacology Diamonds Drug delivery Drug delivery systems Drug Delivery Systems - methods Dynamic mechanical analysis Evaporators Fillers Formulations Fracture surfaces Glass - chemistry Glass transition temperature Infections Infections - drug therapy Injection Injection molding Injection molding machines Materials science Mechanical properties Mice Modulus of elasticity Nanocomposite Nanocomposites Nanocomposites - administration & dosage Nanocomposites - chemistry Nanodiamond Nanohydroxyapatite Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Nanostructure PHBV Photomicrographs Polyesters - chemistry Prophylaxis RAW 264.7 Cells Sustained release Tissue Engineering - methods Transition Temperature Transition temperatures Vancomycin Vancomycin - chemistry Vancomycin - pharmacology
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