Acute hemolytic transfusion reaction associated with anti‐Mta: case report and review of the literature
BACKGROUND Mta (MNS14) is a low‐prevalence antigen of the MNS system. A few cases of hemolytic disease of the fetus and newborn caused by anti‐Mta have been reported in the literature, but up to now this antibody has never been associated with a hemolytic transfusion reaction (HTR). CASE REPORT A 38...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2019-11, Vol.59 (11), p.3314-3318 |
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| container_title | Transfusion (Philadelphia, Pa.) |
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| creator | Claes, Vincent Peyrard, Thierry Deleers, Marie El Kenz, Hanane |
| description | BACKGROUND
Mta (MNS14) is a low‐prevalence antigen of the MNS system. A few cases of hemolytic disease of the fetus and newborn caused by anti‐Mta have been reported in the literature, but up to now this antibody has never been associated with a hemolytic transfusion reaction (HTR).
CASE REPORT
A 38‐year‐old male with sickle cell disease undergoing exchange transfusion presented with shivering, nausea, dyspnea, and pain in the lower limbs. Biologic parameters showed increased hemolysis. The administered red blood cell (RBC) units had been issued by electronic crossmatch due to a negative antibody screening test. In the posttransfusion investigations, crossmatch of the transfused RBC units with the patient's serum showed incompatibility of one unit. The presence of an antibody against a low‐prevalence antigen was suspected and further serologic testing was performed for identification.
RESULTS
Anti‐Mta was identified in the patient's serum. The RBCs of the incompatible unit implicated in the HTR were Mt(a+). An eluate of a posttransfusion blood sample of the patient was nonreactive with the incompatible RBCs, and the direct antiglobulin test was negative.
CONCLUSION
To our knowledge, this is the first case report of an HTR associated with anti‐Mta. |
| doi_str_mv | 10.1111/trf.15521 |
| format | Article |
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Mta (MNS14) is a low‐prevalence antigen of the MNS system. A few cases of hemolytic disease of the fetus and newborn caused by anti‐Mta have been reported in the literature, but up to now this antibody has never been associated with a hemolytic transfusion reaction (HTR).
CASE REPORT
A 38‐year‐old male with sickle cell disease undergoing exchange transfusion presented with shivering, nausea, dyspnea, and pain in the lower limbs. Biologic parameters showed increased hemolysis. The administered red blood cell (RBC) units had been issued by electronic crossmatch due to a negative antibody screening test. In the posttransfusion investigations, crossmatch of the transfused RBC units with the patient's serum showed incompatibility of one unit. The presence of an antibody against a low‐prevalence antigen was suspected and further serologic testing was performed for identification.
RESULTS
Anti‐Mta was identified in the patient's serum. The RBCs of the incompatible unit implicated in the HTR were Mt(a+). An eluate of a posttransfusion blood sample of the patient was nonreactive with the incompatible RBCs, and the direct antiglobulin test was negative.
CONCLUSION
To our knowledge, this is the first case report of an HTR associated with anti‐Mta.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/trf.15521</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Antibodies ; Antigens ; Blood ; Case reports ; Coombs' test ; Dyspnea ; Erythrocytes ; Fetuses ; Hemolytic disease ; Histocompatibility testing ; Incompatibility ; Literature reviews ; Nausea ; Pain ; Respiration ; Shivering ; Sickle cell disease ; Transfusion</subject><ispartof>Transfusion (Philadelphia, Pa.), 2019-11, Vol.59 (11), p.3314-3318</ispartof><rights>2019 AABB</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-7715-568X ; 0000-0001-6398-4009</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftrf.15521$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftrf.15521$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Claes, Vincent</creatorcontrib><creatorcontrib>Peyrard, Thierry</creatorcontrib><creatorcontrib>Deleers, Marie</creatorcontrib><creatorcontrib>El Kenz, Hanane</creatorcontrib><title>Acute hemolytic transfusion reaction associated with anti‐Mta: case report and review of the literature</title><title>Transfusion (Philadelphia, Pa.)</title><description>BACKGROUND
Mta (MNS14) is a low‐prevalence antigen of the MNS system. A few cases of hemolytic disease of the fetus and newborn caused by anti‐Mta have been reported in the literature, but up to now this antibody has never been associated with a hemolytic transfusion reaction (HTR).
CASE REPORT
A 38‐year‐old male with sickle cell disease undergoing exchange transfusion presented with shivering, nausea, dyspnea, and pain in the lower limbs. Biologic parameters showed increased hemolysis. The administered red blood cell (RBC) units had been issued by electronic crossmatch due to a negative antibody screening test. In the posttransfusion investigations, crossmatch of the transfused RBC units with the patient's serum showed incompatibility of one unit. The presence of an antibody against a low‐prevalence antigen was suspected and further serologic testing was performed for identification.
RESULTS
Anti‐Mta was identified in the patient's serum. The RBCs of the incompatible unit implicated in the HTR were Mt(a+). An eluate of a posttransfusion blood sample of the patient was nonreactive with the incompatible RBCs, and the direct antiglobulin test was negative.
CONCLUSION
To our knowledge, this is the first case report of an HTR associated with anti‐Mta.</description><subject>Antibodies</subject><subject>Antigens</subject><subject>Blood</subject><subject>Case reports</subject><subject>Coombs' test</subject><subject>Dyspnea</subject><subject>Erythrocytes</subject><subject>Fetuses</subject><subject>Hemolytic disease</subject><subject>Histocompatibility testing</subject><subject>Incompatibility</subject><subject>Literature reviews</subject><subject>Nausea</subject><subject>Pain</subject><subject>Respiration</subject><subject>Shivering</subject><subject>Sickle cell disease</subject><subject>Transfusion</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkMFKAzEQhoMoWKsH3yDgxcu2maS72XgrxapQEaSeQzab0JTtbk2ylt58BJ_RJzG1npzLfAzfDMOP0DWQEaQaR29HkOcUTtAAcsYzKkR-igaETCADYPQcXYSwJoRQQWCA3FT30eCV2XTNPjqNo1dtsH1wXYu9UToeQIXQaaeiqfHOxRVWbXTfn1_PUd1hrYJJ5rbzMc3rhB_O7HBncVwZ3LhovIq9N5fozKommKu_PkRv8_vl7DFbvDw8zaaLbAsEIOOElrammpMcJjRXpKC6KGxVKwGWVVZNKmq0ULXmloOhtKwrLiooy5xaXmk2RLfHu1vfvfcmRLlxQZumUa3p-iDTRkmIKChL6s0_dd31vk3fScqAMlGIkidrfLR2rjF7ufVuo_xeApGHxGVKXP4mLpev819gP-_Cd7M</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Claes, Vincent</creator><creator>Peyrard, Thierry</creator><creator>Deleers, Marie</creator><creator>El Kenz, Hanane</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7715-568X</orcidid><orcidid>https://orcid.org/0000-0001-6398-4009</orcidid></search><sort><creationdate>201911</creationdate><title>Acute hemolytic transfusion reaction associated with anti‐Mta: case report and review of the literature</title><author>Claes, Vincent ; Peyrard, Thierry ; Deleers, Marie ; El Kenz, Hanane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1011-7028fd2c7051425a062c66fbda91f3bfa4b2ec9adc7f71e228db79b18852f7bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antibodies</topic><topic>Antigens</topic><topic>Blood</topic><topic>Case reports</topic><topic>Coombs' test</topic><topic>Dyspnea</topic><topic>Erythrocytes</topic><topic>Fetuses</topic><topic>Hemolytic disease</topic><topic>Histocompatibility testing</topic><topic>Incompatibility</topic><topic>Literature reviews</topic><topic>Nausea</topic><topic>Pain</topic><topic>Respiration</topic><topic>Shivering</topic><topic>Sickle cell disease</topic><topic>Transfusion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Claes, Vincent</creatorcontrib><creatorcontrib>Peyrard, Thierry</creatorcontrib><creatorcontrib>Deleers, Marie</creatorcontrib><creatorcontrib>El Kenz, Hanane</creatorcontrib><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Claes, Vincent</au><au>Peyrard, Thierry</au><au>Deleers, Marie</au><au>El Kenz, Hanane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute hemolytic transfusion reaction associated with anti‐Mta: case report and review of the literature</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><date>2019-11</date><risdate>2019</risdate><volume>59</volume><issue>11</issue><spage>3314</spage><epage>3318</epage><pages>3314-3318</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><abstract>BACKGROUND
Mta (MNS14) is a low‐prevalence antigen of the MNS system. A few cases of hemolytic disease of the fetus and newborn caused by anti‐Mta have been reported in the literature, but up to now this antibody has never been associated with a hemolytic transfusion reaction (HTR).
CASE REPORT
A 38‐year‐old male with sickle cell disease undergoing exchange transfusion presented with shivering, nausea, dyspnea, and pain in the lower limbs. Biologic parameters showed increased hemolysis. The administered red blood cell (RBC) units had been issued by electronic crossmatch due to a negative antibody screening test. In the posttransfusion investigations, crossmatch of the transfused RBC units with the patient's serum showed incompatibility of one unit. The presence of an antibody against a low‐prevalence antigen was suspected and further serologic testing was performed for identification.
RESULTS
Anti‐Mta was identified in the patient's serum. The RBCs of the incompatible unit implicated in the HTR were Mt(a+). An eluate of a posttransfusion blood sample of the patient was nonreactive with the incompatible RBCs, and the direct antiglobulin test was negative.
CONCLUSION
To our knowledge, this is the first case report of an HTR associated with anti‐Mta.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1111/trf.15521</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-7715-568X</orcidid><orcidid>https://orcid.org/0000-0001-6398-4009</orcidid></addata></record> |
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| ispartof | Transfusion (Philadelphia, Pa.), 2019-11, Vol.59 (11), p.3314-3318 |
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| language | eng |
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| source | Wiley Online Library All Journals |
| subjects | Antibodies Antigens Blood Case reports Coombs' test Dyspnea Erythrocytes Fetuses Hemolytic disease Histocompatibility testing Incompatibility Literature reviews Nausea Pain Respiration Shivering Sickle cell disease Transfusion |
| title | Acute hemolytic transfusion reaction associated with anti‐Mta: case report and review of the literature |
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