Therapeutic Effects of STAT3 Inhibition on Experimental Murine Dry Eye

To investigate the therapeutic effects of targeting signal transducer and activator of transcription-3 (STAT3) activation on the ocular surface damage of dry eye in mice. Adult Balb/C and C57BL/6 mice with benzalkonium chloride (BAC) treatment, lacrimal gland excision, and meibomian gland dysfunctio...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2019-09, Vol.60 (12), p.3776-3785
Hauptverfasser:	Qu, Mingli, Qi, Xia, Wang, Qian, Wan, Lei, Li, Jing, Li, Wei, Li, Yingli, Zhou, Qingjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Ophthalmic Animals Blotting, Western Conjunctiva - metabolism Cytokines - metabolism Disease Models, Animal Dry Eye Syndromes - drug therapy Dry Eye Syndromes - metabolism Dry Eye Syndromes - pathology Enzyme-Linked Immunosorbent Assay Epithelium - metabolism Epithelium, Corneal - metabolism Female Fluorescent Antibody Technique, Indirect Goblet Cells - pathology In Situ Nick-End Labeling Matrix Metalloproteinase 3 - metabolism Matrix Metalloproteinase 9 - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Ophthalmic Solutions Phosphorylation Protein Inhibitors of Activated STAT - therapeutic use Real-Time Polymerase Chain Reaction STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism Tears - physiology
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