Model of Moderate Hyperhomocisteinemia Associated with Mechanical Injury: Dynamics of Morphometric Parameters of Microcirculatory Vessels

A model of moderate hyperhomocysteinemia associated with mechanical injury of the musculoskeletal system was developed and experimentally substantiated. The adequacy of this model for studies of morphological and functional regularities is verified. This model can be used for the development of a ne...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2019-08, Vol.167 (4), p.533-535
Hauptverfasser:	Pigolkin, Yu. I., Nikityuk, D. B., Asanov, A. Yu, Berezovskii, D. P., Bachurin, S. S., Sas’ko, S. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biomedical and Life Sciences Biomedicine Blood clot Cell Biology Disease Models, Animal Genetic aspects Genotype Goats Hyperhomocysteinemia Hyperhomocysteinemia - genetics Hyperhomocysteinemia - pathology Hyperhomocysteinemia - physiopathology Internal Medicine Laboratory Medicine Male Methods Methylenetetrahydrofolate Reductase (NADPH2) - genetics Methylenetetrahydrofolate Reductase (NADPH2) - metabolism Microcirculation - physiology Musculoskeletal system Pathology Polymorphism, Single Nucleotide - genetics Pulmonary embolism Rats Risk factors Single nucleotide polymorphisms Thrombosis Thrombosis - genetics Thrombosis - physiopathology
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Zusammenfassung:	A model of moderate hyperhomocysteinemia associated with mechanical injury of the musculoskeletal system was developed and experimentally substantiated. The adequacy of this model for studies of morphological and functional regularities is verified. This model can be used for the development of a new concept of evaluation of thrombotic complications of mechanical injury.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-019-04567-0