Tumor Cell Behavior in Porous Hydrogels: Effect of Application Technique and Doxorubicin Treatment

The effect of porosity on diffusion characteristics of scaffolds and invasive capacity of MCF-7 and PC-3 tumor cells was studied for gelatin hydrogels. According to MTS test results, the efficiency of population of a macroporous cryogel by cells applied by different techniques increased in the follo...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2019-08, Vol.167 (4), p.590-598
Hauptverfasser:	Zoughaib, M. H., Luong, D. T., Siraeva, Z. Y., Yergeshov, A. A., Salikhova, T. I., Kuznetsova, S. V., Kiyamova, R. G., Abdullin, T. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracyclines Biocompatible Materials - chemistry Biomedical and Life Sciences Biomedicine Cell Adhesion - drug effects Cell Biology Cell culture Cell Proliferation - drug effects Cryogels - chemistry Cytotoxicity Doxorubicin Doxorubicin - chemistry Doxorubicin - pharmacology Ethylenediaminetetraacetic acid Gelatin Humans Hydrogels Hydrogels - chemistry Injection Internal Medicine Laboratory Medicine MCF-7 Cells Methods Pathology PC-3 Cells Porosity Tissue Scaffolds - chemistry Tumor cells Tumors
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Zusammenfassung:	The effect of porosity on diffusion characteristics of scaffolds and invasive capacity of MCF-7 and PC-3 tumor cells was studied for gelatin hydrogels. According to MTS test results, the efficiency of population of a macroporous cryogel by cells applied by different techniques increased in the following order: migration from the monolayer
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-019-04577-y