New bufadienolides extracted from Rhinella marina inhibit Na,K-ATPase and induce apoptosis by activating caspases 3 and 9 in human breast and ovarian cancer cells

•A bufadienolide extracted from cane toad (compound 1) inhibits Na,K-ATPase.•Compound 1 decreases Na,K-ATPase expression.•Compound 1 activates caspase 3 and 9 to induce cell apoptosis. Bufadienolide compounds have been used for growth inhibition and apoptosis induction in tumor cells. Those families...

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Veröffentlicht in:	Steroids 2019-12, Vol.152, p.108490-108490, Article 108490
Hauptverfasser:	Garcia, Israel José Pereira, de Oliveira, Gisele Capanema, de Moura Valadares, Jéssica Martins, Banfi, Felipe Finger, Andrade, Silmara Nunes, Freitas, Túlio Resende, dos Santos Monção Filho, Evaldo, Lima Santos, Hérica de, Júnior, Gerardo Magela Vieira, Chaves, Mariana Helena, de Jesus Rodrigues, Domingos, Sanchez, Bruno Antonio Marinho, Varotti, Fernando P., Barbosa, Leandro Augusto
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bufadienolides Caspase 3 and 9 Na,K-ATPase
Online-Zugang:	Volltext
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