Advancing towards Effective Glioma Therapy: MicroRNA Derived from Umbilical Cord Mesenchymal Stem Cells' Extracellular Vesicles
A glioma, especially a grade IV glioblastoma, is a malignant tumour with a poor prognosis despite growing medical advancements. Researchers have been looking for better and more effective treatments targeting the molecular pathways of gliomas due to glioblastomas' ability to develop resistance...
Gespeichert in:
| Veröffentlicht in: | The Malaysian journal of medical sciences 2019-07, Vol.26 (4), p.5-16 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 16 |
|---|---|
| container_issue | 4 |
| container_start_page | 5 |
| container_title | The Malaysian journal of medical sciences |
| container_volume | 26 |
| creator | Ngadiono, Eko Hardiany, Novi Silvia |
| description | A glioma, especially a grade IV glioblastoma, is a malignant tumour with a poor prognosis despite growing medical advancements. Researchers have been looking for better and more effective treatments targeting the molecular pathways of gliomas due to glioblastomas' ability to develop resistance to chemotherapies. Moreover, glioma stem cells (GSC) contribute to maintaining the glioma population, which benefits from its ability to self-renew and differentiate. Recent research has reported that through the introduction of umbilical cord mesenchymal stem cells (UCMSC) into glioma cells, the growth and development of the glioma cells can be downregulated. It has more currently been found out that UCMSC release extracellular vesicles (EVs) containing miRNA that are responsible for this phenomenon. Therefore, this review analyses literature to discuss all possible miRNAs contained within the UCMSC's EVs and to elaborate on their molecular mechanisms in halting gliomas and GSC growth. This review will also include the challenges and limitations, to account for which more in vivo research is suggested. In conclusion, this review highlights how miRNAs contained within UCMSC's EVs are able to downregulate multiple prominent pathways in the survival of gliomas. |
| doi_str_mv | 10.21315/mjms2019.26.4.2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2287518689</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2630532406</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-1f814a7f9cf5798480199254545ff1c92791d57c4ab0000bd62ca31d55ae520e3</originalsourceid><addsrcrecordid>eNpdUU1vFDEMjRCIbgt3TihSD_Qy23zOJL2ttktBaosELeIWZTMOzWoysyQzLXvirzfQjwP2wZb9nmX7IfSOkjmjnMrjuImZEarnrJ6LOXuBZowqUglO-Es0o1yLimr5Yw_t57whhEtWq9doj1Oha6X0DP1ZtLe2d6H_icfhzqY245X34MZwC_isC0O0-OoGkt3uTvBFcGn4ernAp5BKv8U-DRFfx3XogrMdXg6pxReQoXc3u1gK30aIeAldlz_g1e8xWVfyqbMJf4ccXAf5DXrlbZfh7WM8QNcfV1fLT9X5l7PPy8V55Xitx4p6RYVtvHZeNloJVW7WTIri3lOnWaNpKxsn7JoUW7c1c5aXkrQgGQF-gI4e5m7T8GuCPJoY8t9tbA_DlA1jqpFU1UoX6OF_0M0wpb5sZ1jNieRMkLqgyAOqvCTnBN5sU4g27Qwl5p845kmcQjPCsEJ5_zh4WkdonwlPavB70qKLCA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2630532406</pqid></control><display><type>article</type><title>Advancing towards Effective Glioma Therapy: MicroRNA Derived from Umbilical Cord Mesenchymal Stem Cells' Extracellular Vesicles</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Bioline International</source><source>PubMed Central</source><creator>Ngadiono, Eko ; Hardiany, Novi Silvia</creator><creatorcontrib>Ngadiono, Eko ; Hardiany, Novi Silvia ; International Class Program, Faculty of Medicines Universitas Indonesia, Jakarta, Indonesia ; Department of Biochemistry & Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia</creatorcontrib><description>A glioma, especially a grade IV glioblastoma, is a malignant tumour with a poor prognosis despite growing medical advancements. Researchers have been looking for better and more effective treatments targeting the molecular pathways of gliomas due to glioblastomas' ability to develop resistance to chemotherapies. Moreover, glioma stem cells (GSC) contribute to maintaining the glioma population, which benefits from its ability to self-renew and differentiate. Recent research has reported that through the introduction of umbilical cord mesenchymal stem cells (UCMSC) into glioma cells, the growth and development of the glioma cells can be downregulated. It has more currently been found out that UCMSC release extracellular vesicles (EVs) containing miRNA that are responsible for this phenomenon. Therefore, this review analyses literature to discuss all possible miRNAs contained within the UCMSC's EVs and to elaborate on their molecular mechanisms in halting gliomas and GSC growth. This review will also include the challenges and limitations, to account for which more in vivo research is suggested. In conclusion, this review highlights how miRNAs contained within UCMSC's EVs are able to downregulate multiple prominent pathways in the survival of gliomas.</description><identifier>ISSN: 1394-195X</identifier><identifier>EISSN: 2180-4303</identifier><identifier>DOI: 10.21315/mjms2019.26.4.2</identifier><identifier>PMID: 31496889</identifier><language>eng</language><publisher>Malaysia: Universiti Sains Malaysia Press</publisher><subject>Apoptosis ; Brain cancer ; Cancer therapies ; Cell cycle ; Cell division ; Cytokines ; DNA methylation ; Extracellular vesicles ; Glioma ; Lung cancer ; Medical prognosis ; Medical research ; MicroRNAs ; Proteins ; Radiation ; RNA polymerase ; Stem cells ; Umbilical cord</subject><ispartof>The Malaysian journal of medical sciences, 2019-07, Vol.26 (4), p.5-16</ispartof><rights>Copyright Universiti Sains Malaysia Press Jul/Aug 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-1f814a7f9cf5798480199254545ff1c92791d57c4ab0000bd62ca31d55ae520e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31496889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ngadiono, Eko</creatorcontrib><creatorcontrib>Hardiany, Novi Silvia</creatorcontrib><creatorcontrib>International Class Program, Faculty of Medicines Universitas Indonesia, Jakarta, Indonesia</creatorcontrib><creatorcontrib>Department of Biochemistry & Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia</creatorcontrib><title>Advancing towards Effective Glioma Therapy: MicroRNA Derived from Umbilical Cord Mesenchymal Stem Cells' Extracellular Vesicles</title><title>The Malaysian journal of medical sciences</title><addtitle>Malays J Med Sci</addtitle><description>A glioma, especially a grade IV glioblastoma, is a malignant tumour with a poor prognosis despite growing medical advancements. Researchers have been looking for better and more effective treatments targeting the molecular pathways of gliomas due to glioblastomas' ability to develop resistance to chemotherapies. Moreover, glioma stem cells (GSC) contribute to maintaining the glioma population, which benefits from its ability to self-renew and differentiate. Recent research has reported that through the introduction of umbilical cord mesenchymal stem cells (UCMSC) into glioma cells, the growth and development of the glioma cells can be downregulated. It has more currently been found out that UCMSC release extracellular vesicles (EVs) containing miRNA that are responsible for this phenomenon. Therefore, this review analyses literature to discuss all possible miRNAs contained within the UCMSC's EVs and to elaborate on their molecular mechanisms in halting gliomas and GSC growth. This review will also include the challenges and limitations, to account for which more in vivo research is suggested. In conclusion, this review highlights how miRNAs contained within UCMSC's EVs are able to downregulate multiple prominent pathways in the survival of gliomas.</description><subject>Apoptosis</subject><subject>Brain cancer</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Cell division</subject><subject>Cytokines</subject><subject>DNA methylation</subject><subject>Extracellular vesicles</subject><subject>Glioma</subject><subject>Lung cancer</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>MicroRNAs</subject><subject>Proteins</subject><subject>Radiation</subject><subject>RNA polymerase</subject><subject>Stem cells</subject><subject>Umbilical cord</subject><issn>1394-195X</issn><issn>2180-4303</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdUU1vFDEMjRCIbgt3TihSD_Qy23zOJL2ttktBaosELeIWZTMOzWoysyQzLXvirzfQjwP2wZb9nmX7IfSOkjmjnMrjuImZEarnrJ6LOXuBZowqUglO-Es0o1yLimr5Yw_t57whhEtWq9doj1Oha6X0DP1ZtLe2d6H_icfhzqY245X34MZwC_isC0O0-OoGkt3uTvBFcGn4ernAp5BKv8U-DRFfx3XogrMdXg6pxReQoXc3u1gK30aIeAldlz_g1e8xWVfyqbMJf4ccXAf5DXrlbZfh7WM8QNcfV1fLT9X5l7PPy8V55Xitx4p6RYVtvHZeNloJVW7WTIri3lOnWaNpKxsn7JoUW7c1c5aXkrQgGQF-gI4e5m7T8GuCPJoY8t9tbA_DlA1jqpFU1UoX6OF_0M0wpb5sZ1jNieRMkLqgyAOqvCTnBN5sU4g27Qwl5p845kmcQjPCsEJ5_zh4WkdonwlPavB70qKLCA</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Ngadiono, Eko</creator><creator>Hardiany, Novi Silvia</creator><general>Universiti Sains Malaysia Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190701</creationdate><title>Advancing towards Effective Glioma Therapy: MicroRNA Derived from Umbilical Cord Mesenchymal Stem Cells' Extracellular Vesicles</title><author>Ngadiono, Eko ; Hardiany, Novi Silvia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-1f814a7f9cf5798480199254545ff1c92791d57c4ab0000bd62ca31d55ae520e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Apoptosis</topic><topic>Brain cancer</topic><topic>Cancer therapies</topic><topic>Cell cycle</topic><topic>Cell division</topic><topic>Cytokines</topic><topic>DNA methylation</topic><topic>Extracellular vesicles</topic><topic>Glioma</topic><topic>Lung cancer</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>MicroRNAs</topic><topic>Proteins</topic><topic>Radiation</topic><topic>RNA polymerase</topic><topic>Stem cells</topic><topic>Umbilical cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ngadiono, Eko</creatorcontrib><creatorcontrib>Hardiany, Novi Silvia</creatorcontrib><creatorcontrib>International Class Program, Faculty of Medicines Universitas Indonesia, Jakarta, Indonesia</creatorcontrib><creatorcontrib>Department of Biochemistry & Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>The Malaysian journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ngadiono, Eko</au><au>Hardiany, Novi Silvia</au><aucorp>International Class Program, Faculty of Medicines Universitas Indonesia, Jakarta, Indonesia</aucorp><aucorp>Department of Biochemistry & Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advancing towards Effective Glioma Therapy: MicroRNA Derived from Umbilical Cord Mesenchymal Stem Cells' Extracellular Vesicles</atitle><jtitle>The Malaysian journal of medical sciences</jtitle><addtitle>Malays J Med Sci</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>26</volume><issue>4</issue><spage>5</spage><epage>16</epage><pages>5-16</pages><issn>1394-195X</issn><eissn>2180-4303</eissn><abstract>A glioma, especially a grade IV glioblastoma, is a malignant tumour with a poor prognosis despite growing medical advancements. Researchers have been looking for better and more effective treatments targeting the molecular pathways of gliomas due to glioblastomas' ability to develop resistance to chemotherapies. Moreover, glioma stem cells (GSC) contribute to maintaining the glioma population, which benefits from its ability to self-renew and differentiate. Recent research has reported that through the introduction of umbilical cord mesenchymal stem cells (UCMSC) into glioma cells, the growth and development of the glioma cells can be downregulated. It has more currently been found out that UCMSC release extracellular vesicles (EVs) containing miRNA that are responsible for this phenomenon. Therefore, this review analyses literature to discuss all possible miRNAs contained within the UCMSC's EVs and to elaborate on their molecular mechanisms in halting gliomas and GSC growth. This review will also include the challenges and limitations, to account for which more in vivo research is suggested. In conclusion, this review highlights how miRNAs contained within UCMSC's EVs are able to downregulate multiple prominent pathways in the survival of gliomas.</abstract><cop>Malaysia</cop><pub>Universiti Sains Malaysia Press</pub><pmid>31496889</pmid><doi>10.21315/mjms2019.26.4.2</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1394-195X |
| ispartof | The Malaysian journal of medical sciences, 2019-07, Vol.26 (4), p.5-16 |
| issn | 1394-195X 2180-4303 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2287518689 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Bioline International; PubMed Central |
| subjects | Apoptosis Brain cancer Cancer therapies Cell cycle Cell division Cytokines DNA methylation Extracellular vesicles Glioma Lung cancer Medical prognosis Medical research MicroRNAs Proteins Radiation RNA polymerase Stem cells Umbilical cord |
| title | Advancing towards Effective Glioma Therapy: MicroRNA Derived from Umbilical Cord Mesenchymal Stem Cells' Extracellular Vesicles |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T04%3A22%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Advancing%20towards%20Effective%20Glioma%20Therapy:%20MicroRNA%20Derived%20from%20Umbilical%20Cord%20Mesenchymal%20Stem%20Cells'%20Extracellular%20Vesicles&rft.jtitle=The%20Malaysian%20journal%20of%20medical%20sciences&rft.au=Ngadiono,%20Eko&rft.aucorp=International%20Class%20Program,%20Faculty%20of%20Medicines%20Universitas%20Indonesia,%20Jakarta,%20Indonesia&rft.date=2019-07-01&rft.volume=26&rft.issue=4&rft.spage=5&rft.epage=16&rft.pages=5-16&rft.issn=1394-195X&rft.eissn=2180-4303&rft_id=info:doi/10.21315/mjms2019.26.4.2&rft_dat=%3Cproquest_cross%3E2630532406%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2630532406&rft_id=info:pmid/31496889&rfr_iscdi=true |