The effect of certolizumab drug concentration and anti-drug antibodies on TNF neutralisation

Tumour necrosis factor (TNF) inhibitors like certolizumab, elicit an immunogenic response leading to the formation of anti-drug antibodies (ADAs). We sought to mechanistically investigate the relationship between certolizumab concentrations, ADAs, and the effective TNF neutralising capacity in sera...

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Veröffentlicht in:	Clinical and Experimental Rheumatology 2020-03, Vol.38 (2), p.306-313
Hauptverfasser:	Berkhout, Lea C, Vogelzang, Erik H, Hart, Margreet M, Loeff, Floris C, Dijk, Lisanne, Derksen, Ninotska I L, Wieringa, Roeland, van Leeuwen, W Astrid, Krieckaert, Charlotte L M, de Vries, Annick, Nurmohamed, Michael T, Wolbink, Gerrit J, Rispens, Theo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab Antibodies Antibodies, Monoclonal, Humanized - immunology Antibodies, Neutralizing - immunology Antirheumatic Agents - immunology Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Certolizumab Pegol Humans Immunoglobulin Fab Fragments - immunology Infliximab Tumor Necrosis Factor-alpha - antagonists & inhibitors
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