Anti-Ischemic Activity of Triamine ALM-802 under Conditions of Endothelial Dysfunction

Anti-ischemic activity of N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino] ethyl}-1,2-ethanediamine (ALM-802) based on the structure of standard p-FOX inhibitors trimetazidine and ranolazine was studied on the model of endocardial ischemia in intact rats and animals with endothelial...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2019-08, Vol.167 (4), p.460-463
Hauptverfasser:	Barchukov, V. V., Tsorin, I. B., Likhosherstov, A. M., Vititnova, M. B., Mokrov, G. V., Gudasheva, T. A., Kryzhanovskii, S. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Animals Biomedical and Life Sciences Biomedicine Cell Biology Electrophysiology Endothelium Hyperhomocysteinemia Hyperhomocysteinemia - chemically induced Hyperhomocysteinemia - drug therapy Internal Medicine Ischemia Isoproterenol Isoproterenol - toxicity Laboratory Medicine Male Methionine Myocardial Infarction - chemically induced Myocardial Infarction - drug therapy Myocardial ischemia Pathology Ranolazine - therapeutic use Rats Rodents Trimetazidine Trimetazidine - therapeutic use
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