The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1 (DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue development and homeostasis 1 – 4 . They are also implicated in human developmental disorders and cancers 5 – 8 , supporting the critical...

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Veröffentlicht in:	Nature (London) 2019-09, Vol.573 (7773), p.281-286
Hauptverfasser:	Weinberg, Daniel N., Papillon-Cavanagh, Simon, Chen, Haifen, Yue, Yuan, Chen, Xiao, Rajagopalan, Kartik N., Horth, Cynthia, McGuire, John T., Xu, Xinjing, Nikbakht, Hamid, Lemiesz, Agata E., Marchione, Dylan M., Marunde, Matthew R., Meiners, Matthew J., Cheek, Marcus A., Keogh, Michael-Christopher, Bareke, Eric, Djedid, Anissa, Harutyunyan, Ashot S., Jabado, Nada, Garcia, Benjamin A., Li, Haitao, Allis, C. David, Majewski, Jacek, Lu, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 13/106 38/91 42/41 631/136/142 631/1647/2210/2211 631/208/176/1988 631/337/100/2285 631/67/1536 Ablation Analysis Animals Binding Bioinformatics Cell fate Cell Line Children Chromatin CpG islands Deoxyribonucleic acid Developmental disabilities DNA DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methylation DNA methyltransferase DNA, Intergenic - metabolism DNMT1 protein Euchromatin Gene expression Genome-Wide Association Study Genomes Genomics Growth Disorders - genetics Growth Disorders - physiopathology Haploinsufficiency Histone H3 Histone methyltransferase Histones Histones - metabolism Homeostasis Humanities and Social Sciences Humans Letter Localization Maintenance Mass spectrometry Methylation Methyltransferases Mice Missense mutation multidisciplinary Mutation Post-translation Post-translational modification Protein Binding Protein Domains Protein Transport Robinson, J Science Science (multidisciplinary) Scientific imaging Sotos Syndrome - genetics Sotos Syndrome - physiopathology Tumors
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