The Current Role of Microfluidics in Radiofluorination Chemistry
The current utilization of positron emission tomography (PET) imaging is limited due to the high costs associated with production facility start-up and operations; subsequently, there has been a movement towards microfluidic synthesis of radiolabeled imaging pharmaceuticals (tracers). In this review...
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| Veröffentlicht in: | Molecular imaging and biology 2020-06, Vol.22 (3), p.463-475 |
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| container_title | Molecular imaging and biology |
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| creator | Knapp, Karla-Anne Nickels, Michael L. Manning, H. Charles |
| description | The current utilization of positron emission tomography (PET) imaging is limited due to the high costs associated with production facility start-up and operations; subsequently, there has been a movement towards microfluidic synthesis of radiolabeled imaging pharmaceuticals (tracers). In this review, we summarize the current status of microfluidic radiosynthesis units for producing fluorine-18 labeled PET imaging tracers, including a discussion of the relative strengths and weaknesses of such devices. In addition, we provide a brief overview of the radiotracers that have been produced using microfluidic devices to date. Finally, we discuss the prospects for the future of this field, including the potential of newly envisioned devices developed that may allow operators to easily synthesize specialized tracers for individual patient doses. |
| doi_str_mv | 10.1007/s11307-019-01414-6 |
| format | Article |
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All Rights Reserved.</rights><rights>World Molecular Imaging Society 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-bc23ffc51d40812f31fc805ee8504aadfbeeef393560b3598ac782a63fb8d7b43</citedby><cites>FETCH-LOGICAL-c469t-bc23ffc51d40812f31fc805ee8504aadfbeeef393560b3598ac782a63fb8d7b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11307-019-01414-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11307-019-01414-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31485889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knapp, Karla-Anne</creatorcontrib><creatorcontrib>Nickels, Michael L.</creatorcontrib><creatorcontrib>Manning, H. 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Finally, we discuss the prospects for the future of this field, including the potential of newly envisioned devices developed that may allow operators to easily synthesize specialized tracers for individual patient doses.</description><subject>Animals</subject><subject>Fluorine</subject><subject>Fluorine Radioisotopes - chemistry</subject><subject>Humans</subject><subject>Imaging</subject><subject>Isotope Labeling - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microfluidics</subject><subject>Microfluidics - instrumentation</subject><subject>Microfluidics - methods</subject><subject>Organic chemistry</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron-Emission Tomography - methods</subject><subject>Radioactive tracers</subject><subject>Radiology</subject><subject>Radiopharmaceuticals - chemical synthesis</subject><subject>Review Article</subject><subject>Tomography</subject><issn>1536-1632</issn><issn>1860-2002</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtLxDAUhYMovv-ACym4cVO9N6-mO2XwBYowjOuQtolGOu2YtIv590ZnVHAxi3BD7nfPDecQcoJwgQDFZURkUOSAZToceS63yD4qCTkFoNvpLpjMUTK6Rw5ifAfAAinbJXsMuRJKlfvkavZms8kYgu2GbNq3Nutd9uTr0Lt29I2vY-a7bGoa__XQB9-ZwfddNnmzcx-HsDwiO8600R6v6yF5ub2ZTe7zx-e7h8n1Y15zWQ55VVPmXC2w4aCQOoauViCsVQK4MY2rrLWOlUxIqJgolakLRY1krlJNUXF2SM5XuovQf4w2Djrtr23bms72Y9SUKoGItFQJPfuHvvdj6NLvNOUgSykUKzZSVHEGMhmbKLqikiMxBuv0Ivi5CUuNoL9S0KsUdIL1dwpapqHTtfRYzW3zO_JjewLYCoip1b3a8Ld7g-wnhhuQsg</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Knapp, Karla-Anne</creator><creator>Nickels, Michael L.</creator><creator>Manning, H. 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| subjects | Animals Fluorine Fluorine Radioisotopes - chemistry Humans Imaging Isotope Labeling - methods Medicine Medicine & Public Health Microfluidics Microfluidics - instrumentation Microfluidics - methods Organic chemistry Positron emission Positron emission tomography Positron-Emission Tomography - methods Radioactive tracers Radiology Radiopharmaceuticals - chemical synthesis Review Article Tomography |
| title | The Current Role of Microfluidics in Radiofluorination Chemistry |
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