Incidence and Outcomes of Perianal Disease in an Asian Population with Crohn’s Disease: A Nationwide Population-Based Study
Background Little is known about the natural history of perianal fistulas in Asian populations with Crohn’s disease (CD). Aims We investigated the incidence and outcomes of perianal CD (pCD) in Korean CD patients. Methods A nationwide population-based cohort of 6265 CD patients diagnosed in 2010–201...
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| creator | Song, Eun Mi Lee, Ho-Su Kim, Ye-Jee Oh, Eun Hye Ham, Nam Seok Kim, Jeongseok Hwang, Sung Wook Park, Sang Hyoung Yang, Dong-Hoon Ye, Byong Duk Byeon, Jeong-Sik Myung, Seung-Jae Lee, Jong Lyul Yoon, Yong Sik Yu, Chang Sik Yang, Suk-Kyun |
| description | Background
Little is known about the natural history of perianal fistulas in Asian populations with Crohn’s disease (CD).
Aims
We investigated the incidence and outcomes of perianal CD (pCD) in Korean CD patients.
Methods
A nationwide population-based cohort of 6265 CD patients diagnosed in 2010–2014 was analyzed to investigate the incidence and outcomes of pCD. The results were validated in a hospital-based cohort of 2923 CD patients diagnosed in 1981–2015. Factors associated with pCD development were analyzed. The incidence and outcomes of pCD were compared between the prebiologic and biologic eras.
Results
pCD occurred in 39.2% of the population-based cohort and 56.1% of the hospital-based cohort during the median follow-up of 4.2 and 8.5 years, respectively. The cumulative incidence of pCD was 40.0% at 5 years after CD diagnosis in the population-based cohort and 62.5% at 20 years in the hospital-based cohort. In multivariate analysis, pCD development was positively associated with male sex, younger age and colonic involvement at diagnosis, early diagnosis, and CD diagnosis in the prebiologic era. The cumulative probability of proctectomy at 10, 20, and 30 years after pCD diagnosis was 2.9%, 12.2%, and 16.2%, respectively. The cumulative incidence of pCD occurring after CD diagnosis and the cumulative probability of proctectomy were significantly lower in the biologic era than in the prebiologic era (
p
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| doi_str_mv | 10.1007/s10620-019-05819-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2285108175</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712934717</galeid><sourcerecordid>A712934717</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-75bdc8a76028ac1c2779a25aca0bad50276a2266dcd7e2c85c598058e4cd3a8f3</originalsourceid><addsrcrecordid>eNp9kd9qFDEUxoModq2-gBcS8MabqUlm8s-77fqvUGxBvQ7Z5EybMpOsyQylF4Kv4ev5JKa7rVURCSThnN_3kZwPoaeUHFBC5MtCiWCkIVQ3hKu663toQblsG8aFuo8WhIp6p1TsoUelXBBCtKTiIdpraae41t0CfT2KLniIDrCNHp_Mk0sjFJx6fAo52GgH_DoUsAVwiJXBy1Kr-DRt5sFOIUV8GaZzvMrpPP749r3c0q_wEn_YApfV_ze-Oaxdjz9Os796jB70dijw5ObcR5_fvvm0et8cn7w7Wi2PG9d1bGokX3unrBSEKeuoY1Jqy7h1lqyt54RJYRkTwjsvgTnFHdeqjgQ651ur-nYfvdj5bnL6MkOZzBiKg2GwEdJcDGOKU6Ko5BV9_hd6keZcx7ClOqaV1PSOOrMDmBD7NGXrrk3NUlKm205SWamDf1B1eRiDSxH6UOt_CNhO4HIqJUNvNjmMNl8ZSsx15maXuamZm23mRlfRs5sXz-sR_C_JbcgVaHdAqa14BvnuS_-x_QmfhrZb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2284298791</pqid></control><display><type>article</type><title>Incidence and Outcomes of Perianal Disease in an Asian Population with Crohn’s Disease: A Nationwide Population-Based Study</title><source>Springer Nature - Complete Springer Journals</source><creator>Song, Eun Mi ; Lee, Ho-Su ; Kim, Ye-Jee ; Oh, Eun Hye ; Ham, Nam Seok ; Kim, Jeongseok ; Hwang, Sung Wook ; Park, Sang Hyoung ; Yang, Dong-Hoon ; Ye, Byong Duk ; Byeon, Jeong-Sik ; Myung, Seung-Jae ; Lee, Jong Lyul ; Yoon, Yong Sik ; Yu, Chang Sik ; Yang, Suk-Kyun</creator><creatorcontrib>Song, Eun Mi ; Lee, Ho-Su ; Kim, Ye-Jee ; Oh, Eun Hye ; Ham, Nam Seok ; Kim, Jeongseok ; Hwang, Sung Wook ; Park, Sang Hyoung ; Yang, Dong-Hoon ; Ye, Byong Duk ; Byeon, Jeong-Sik ; Myung, Seung-Jae ; Lee, Jong Lyul ; Yoon, Yong Sik ; Yu, Chang Sik ; Yang, Suk-Kyun</creatorcontrib><description>Background
Little is known about the natural history of perianal fistulas in Asian populations with Crohn’s disease (CD).
Aims
We investigated the incidence and outcomes of perianal CD (pCD) in Korean CD patients.
Methods
A nationwide population-based cohort of 6265 CD patients diagnosed in 2010–2014 was analyzed to investigate the incidence and outcomes of pCD. The results were validated in a hospital-based cohort of 2923 CD patients diagnosed in 1981–2015. Factors associated with pCD development were analyzed. The incidence and outcomes of pCD were compared between the prebiologic and biologic eras.
Results
pCD occurred in 39.2% of the population-based cohort and 56.1% of the hospital-based cohort during the median follow-up of 4.2 and 8.5 years, respectively. The cumulative incidence of pCD was 40.0% at 5 years after CD diagnosis in the population-based cohort and 62.5% at 20 years in the hospital-based cohort. In multivariate analysis, pCD development was positively associated with male sex, younger age and colonic involvement at diagnosis, early diagnosis, and CD diagnosis in the prebiologic era. The cumulative probability of proctectomy at 10, 20, and 30 years after pCD diagnosis was 2.9%, 12.2%, and 16.2%, respectively. The cumulative incidence of pCD occurring after CD diagnosis and the cumulative probability of proctectomy were significantly lower in the biologic era than in the prebiologic era (
p
< 0.001 and
p
= 0.03, respectively).
Conclusions
Compared with Western patients with CD, Korean patients show a high incidence of pCD but have a low probability of proctectomy, suggesting the favorable course of pCD.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-019-05819-9</identifier><identifier>PMID: 31485994</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Codes ; Comparative analysis ; Crohn's disease ; Epidemiology ; Fecal incontinence ; Fistula ; Gastroenterology ; Health insurance ; Hepatology ; Hospitals ; Inflammatory bowel disease ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Oncology ; Original Article ; Population ; Population-based studies ; Studies ; Transplant Surgery</subject><ispartof>Digestive diseases and sciences, 2020-04, Vol.65 (4), p.1189-1196</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Digestive Diseases and Sciences is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-75bdc8a76028ac1c2779a25aca0bad50276a2266dcd7e2c85c598058e4cd3a8f3</citedby><cites>FETCH-LOGICAL-c442t-75bdc8a76028ac1c2779a25aca0bad50276a2266dcd7e2c85c598058e4cd3a8f3</cites><orcidid>0000-0003-2772-2575</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-019-05819-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-019-05819-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31485994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Eun Mi</creatorcontrib><creatorcontrib>Lee, Ho-Su</creatorcontrib><creatorcontrib>Kim, Ye-Jee</creatorcontrib><creatorcontrib>Oh, Eun Hye</creatorcontrib><creatorcontrib>Ham, Nam Seok</creatorcontrib><creatorcontrib>Kim, Jeongseok</creatorcontrib><creatorcontrib>Hwang, Sung Wook</creatorcontrib><creatorcontrib>Park, Sang Hyoung</creatorcontrib><creatorcontrib>Yang, Dong-Hoon</creatorcontrib><creatorcontrib>Ye, Byong Duk</creatorcontrib><creatorcontrib>Byeon, Jeong-Sik</creatorcontrib><creatorcontrib>Myung, Seung-Jae</creatorcontrib><creatorcontrib>Lee, Jong Lyul</creatorcontrib><creatorcontrib>Yoon, Yong Sik</creatorcontrib><creatorcontrib>Yu, Chang Sik</creatorcontrib><creatorcontrib>Yang, Suk-Kyun</creatorcontrib><title>Incidence and Outcomes of Perianal Disease in an Asian Population with Crohn’s Disease: A Nationwide Population-Based Study</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
Little is known about the natural history of perianal fistulas in Asian populations with Crohn’s disease (CD).
Aims
We investigated the incidence and outcomes of perianal CD (pCD) in Korean CD patients.
Methods
A nationwide population-based cohort of 6265 CD patients diagnosed in 2010–2014 was analyzed to investigate the incidence and outcomes of pCD. The results were validated in a hospital-based cohort of 2923 CD patients diagnosed in 1981–2015. Factors associated with pCD development were analyzed. The incidence and outcomes of pCD were compared between the prebiologic and biologic eras.
Results
pCD occurred in 39.2% of the population-based cohort and 56.1% of the hospital-based cohort during the median follow-up of 4.2 and 8.5 years, respectively. The cumulative incidence of pCD was 40.0% at 5 years after CD diagnosis in the population-based cohort and 62.5% at 20 years in the hospital-based cohort. In multivariate analysis, pCD development was positively associated with male sex, younger age and colonic involvement at diagnosis, early diagnosis, and CD diagnosis in the prebiologic era. The cumulative probability of proctectomy at 10, 20, and 30 years after pCD diagnosis was 2.9%, 12.2%, and 16.2%, respectively. The cumulative incidence of pCD occurring after CD diagnosis and the cumulative probability of proctectomy were significantly lower in the biologic era than in the prebiologic era (
p
< 0.001 and
p
= 0.03, respectively).
Conclusions
Compared with Western patients with CD, Korean patients show a high incidence of pCD but have a low probability of proctectomy, suggesting the favorable course of pCD.</description><subject>Biochemistry</subject><subject>Codes</subject><subject>Comparative analysis</subject><subject>Crohn's disease</subject><subject>Epidemiology</subject><subject>Fecal incontinence</subject><subject>Fistula</subject><subject>Gastroenterology</subject><subject>Health insurance</subject><subject>Hepatology</subject><subject>Hospitals</subject><subject>Inflammatory bowel disease</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Population</subject><subject>Population-based studies</subject><subject>Studies</subject><subject>Transplant Surgery</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kd9qFDEUxoModq2-gBcS8MabqUlm8s-77fqvUGxBvQ7Z5EybMpOsyQylF4Kv4ev5JKa7rVURCSThnN_3kZwPoaeUHFBC5MtCiWCkIVQ3hKu663toQblsG8aFuo8WhIp6p1TsoUelXBBCtKTiIdpraae41t0CfT2KLniIDrCNHp_Mk0sjFJx6fAo52GgH_DoUsAVwiJXBy1Kr-DRt5sFOIUV8GaZzvMrpPP749r3c0q_wEn_YApfV_ze-Oaxdjz9Os796jB70dijw5ObcR5_fvvm0et8cn7w7Wi2PG9d1bGokX3unrBSEKeuoY1Jqy7h1lqyt54RJYRkTwjsvgTnFHdeqjgQ651ur-nYfvdj5bnL6MkOZzBiKg2GwEdJcDGOKU6Ko5BV9_hd6keZcx7ClOqaV1PSOOrMDmBD7NGXrrk3NUlKm205SWamDf1B1eRiDSxH6UOt_CNhO4HIqJUNvNjmMNl8ZSsx15maXuamZm23mRlfRs5sXz-sR_C_JbcgVaHdAqa14BvnuS_-x_QmfhrZb</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Song, Eun Mi</creator><creator>Lee, Ho-Su</creator><creator>Kim, Ye-Jee</creator><creator>Oh, Eun Hye</creator><creator>Ham, Nam Seok</creator><creator>Kim, Jeongseok</creator><creator>Hwang, Sung Wook</creator><creator>Park, Sang Hyoung</creator><creator>Yang, Dong-Hoon</creator><creator>Ye, Byong Duk</creator><creator>Byeon, Jeong-Sik</creator><creator>Myung, Seung-Jae</creator><creator>Lee, Jong Lyul</creator><creator>Yoon, Yong Sik</creator><creator>Yu, Chang Sik</creator><creator>Yang, Suk-Kyun</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2772-2575</orcidid></search><sort><creationdate>20200401</creationdate><title>Incidence and Outcomes of Perianal Disease in an Asian Population with Crohn’s Disease: A Nationwide Population-Based Study</title><author>Song, Eun Mi ; Lee, Ho-Su ; Kim, Ye-Jee ; Oh, Eun Hye ; Ham, Nam Seok ; Kim, Jeongseok ; Hwang, Sung Wook ; Park, Sang Hyoung ; Yang, Dong-Hoon ; Ye, Byong Duk ; Byeon, Jeong-Sik ; Myung, Seung-Jae ; Lee, Jong Lyul ; Yoon, Yong Sik ; Yu, Chang Sik ; Yang, Suk-Kyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-75bdc8a76028ac1c2779a25aca0bad50276a2266dcd7e2c85c598058e4cd3a8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biochemistry</topic><topic>Codes</topic><topic>Comparative analysis</topic><topic>Crohn's disease</topic><topic>Epidemiology</topic><topic>Fecal incontinence</topic><topic>Fistula</topic><topic>Gastroenterology</topic><topic>Health insurance</topic><topic>Hepatology</topic><topic>Hospitals</topic><topic>Inflammatory bowel disease</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Population</topic><topic>Population-based studies</topic><topic>Studies</topic><topic>Transplant Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Eun Mi</creatorcontrib><creatorcontrib>Lee, Ho-Su</creatorcontrib><creatorcontrib>Kim, Ye-Jee</creatorcontrib><creatorcontrib>Oh, Eun Hye</creatorcontrib><creatorcontrib>Ham, Nam Seok</creatorcontrib><creatorcontrib>Kim, Jeongseok</creatorcontrib><creatorcontrib>Hwang, Sung Wook</creatorcontrib><creatorcontrib>Park, Sang Hyoung</creatorcontrib><creatorcontrib>Yang, Dong-Hoon</creatorcontrib><creatorcontrib>Ye, Byong Duk</creatorcontrib><creatorcontrib>Byeon, Jeong-Sik</creatorcontrib><creatorcontrib>Myung, Seung-Jae</creatorcontrib><creatorcontrib>Lee, Jong Lyul</creatorcontrib><creatorcontrib>Yoon, Yong Sik</creatorcontrib><creatorcontrib>Yu, Chang Sik</creatorcontrib><creatorcontrib>Yang, Suk-Kyun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Eun Mi</au><au>Lee, Ho-Su</au><au>Kim, Ye-Jee</au><au>Oh, Eun Hye</au><au>Ham, Nam Seok</au><au>Kim, Jeongseok</au><au>Hwang, Sung Wook</au><au>Park, Sang Hyoung</au><au>Yang, Dong-Hoon</au><au>Ye, Byong Duk</au><au>Byeon, Jeong-Sik</au><au>Myung, Seung-Jae</au><au>Lee, Jong Lyul</au><au>Yoon, Yong Sik</au><au>Yu, Chang Sik</au><au>Yang, Suk-Kyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence and Outcomes of Perianal Disease in an Asian Population with Crohn’s Disease: A Nationwide Population-Based Study</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>65</volume><issue>4</issue><spage>1189</spage><epage>1196</epage><pages>1189-1196</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><abstract>Background
Little is known about the natural history of perianal fistulas in Asian populations with Crohn’s disease (CD).
Aims
We investigated the incidence and outcomes of perianal CD (pCD) in Korean CD patients.
Methods
A nationwide population-based cohort of 6265 CD patients diagnosed in 2010–2014 was analyzed to investigate the incidence and outcomes of pCD. The results were validated in a hospital-based cohort of 2923 CD patients diagnosed in 1981–2015. Factors associated with pCD development were analyzed. The incidence and outcomes of pCD were compared between the prebiologic and biologic eras.
Results
pCD occurred in 39.2% of the population-based cohort and 56.1% of the hospital-based cohort during the median follow-up of 4.2 and 8.5 years, respectively. The cumulative incidence of pCD was 40.0% at 5 years after CD diagnosis in the population-based cohort and 62.5% at 20 years in the hospital-based cohort. In multivariate analysis, pCD development was positively associated with male sex, younger age and colonic involvement at diagnosis, early diagnosis, and CD diagnosis in the prebiologic era. The cumulative probability of proctectomy at 10, 20, and 30 years after pCD diagnosis was 2.9%, 12.2%, and 16.2%, respectively. The cumulative incidence of pCD occurring after CD diagnosis and the cumulative probability of proctectomy were significantly lower in the biologic era than in the prebiologic era (
p
< 0.001 and
p
= 0.03, respectively).
Conclusions
Compared with Western patients with CD, Korean patients show a high incidence of pCD but have a low probability of proctectomy, suggesting the favorable course of pCD.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31485994</pmid><doi>10.1007/s10620-019-05819-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2772-2575</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2020-04, Vol.65 (4), p.1189-1196 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2285108175 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Biochemistry Codes Comparative analysis Crohn's disease Epidemiology Fecal incontinence Fistula Gastroenterology Health insurance Hepatology Hospitals Inflammatory bowel disease Medical research Medicine Medicine & Public Health Medicine, Experimental Oncology Original Article Population Population-based studies Studies Transplant Surgery |
| title | Incidence and Outcomes of Perianal Disease in an Asian Population with Crohn’s Disease: A Nationwide Population-Based Study |
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