Mn(i)-Catalyzed nucleophilic addition/ring expansion via C-H activation and C-C cleavage

Mn(i)-Catalyzed synthesis of seven- or eight-membered carbocycles is disclosed via C-H activation of heteroarenes and coupling with alkyne-functionalized 1,3-cyclopentadiones or 1,3-cyclohexadiones. This n to n + 2 (n = 5, 6) ring expansion reaction proceeded via a C-H alkenylation/carbonyl addition...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2019-09, Vol.55 (72), p.10764-10767
Hauptverfasser:	Liu, Bingxian, Yuan, Yin, Hu, Panjie, Zheng, Guangfan, Bai, Dachang, Chang, Junbiao, Li, Xingwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Aldehydes Alkynes Carbonyls Chemical synthesis Cleavage Crystallography
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container_end_page	10767
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container_title	Chemical communications (Cambridge, England)
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creator	Liu, Bingxian Yuan, Yin Hu, Panjie Zheng, Guangfan Bai, Dachang Chang, Junbiao Li, Xingwei
description	Mn(i)-Catalyzed synthesis of seven- or eight-membered carbocycles is disclosed via C-H activation of heteroarenes and coupling with alkyne-functionalized 1,3-cyclopentadiones or 1,3-cyclohexadiones. This n to n + 2 (n = 5, 6) ring expansion reaction proceeded via a C-H alkenylation/carbonyl addition/retro-Aldol cascade. Structurally diverse mid-sized carbocycles were constructed via cleavage of both C-H and C-C bonds in a single operation.
doi_str_mv	10.1039/c9cc05973c
format	Article
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source	Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects	Activation Aldehydes Alkynes Carbonyls Chemical synthesis Cleavage Crystallography
title	Mn(i)-Catalyzed nucleophilic addition/ring expansion via C-H activation and C-C cleavage
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