Elevated circulating levels of secreted frizzled-related protein 4 in relation to insulin resistance and androgens in women with polycystic ovary syndrome
Purpose Secreted frizzled-related protein 4 (SFRP4) is an adipokine involving in apoptotic process during ovulation and energy metabolism. Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder associated with insulin resistance and impaired oocyte maturation as well as apo...
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| Veröffentlicht in: | Journal of endocrinological investigation 2020-03, Vol.43 (3), p.305-313 |
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| creator | Bicer, M. Alarslan, P. Guler, A. Demir, I. Aslanipour, B. Calan, M. |
| description | Purpose
Secreted frizzled-related protein 4 (SFRP4) is an adipokine involving in apoptotic process during ovulation and energy metabolism. Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder associated with insulin resistance and impaired oocyte maturation as well as apoptotic dysfunctions through oocyte development. Our aim was to determine whether there was an alteration in levels of SFRP4 and if there was an association between metabolic or hormonal parameters and SFRP4 in women with PCOS.
Methods
We enrolled 80 subjects with PCOS and 80 age- and body mass index (BMI)-matched subjects with normal menstrual cycle into current case–control study. Metabolic and hormonal parameters of enrolled subjects were determined. Circulating SFRP4 levels were measured with ELISA method.
Results
We found that circulating SFRP4 levels were elevated in women with PCOS with respect to controls (5.87 ± 1.91 vs. 3.72 ± 1.29 ng/ml,
P |
| doi_str_mv | 10.1007/s40618-019-01108-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2285101367</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2353609789</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-78d727b1451a748fd3df9920719b1256ca530558d3454c60f1cc173eb6b2df9e3</originalsourceid><addsrcrecordid>eNp9kcuOFSEQhonROOPoC7gwJG7ctHJt6KWZjJdkEje6JjRdfWRCwxHoMWcexaeVPme8xIWLKoqqrwoqP0LPKXlNCVFviiA91R2hQzNKdCceoHOqGOk01_3Dv-Iz9KSUG0K44lo9RmecCt0PAz1HP64C3NoKE3Y-uzXY6uMOtxyEgtOMC7gMW3nO_u4uwNRlCEd-n1MFH7HAzR2TPkVcU7uWNRxzxZdqowNs47RZTjuIZeO_pwWa9_Ur3qdwcIdSvcPp1uYDLoeNXOApejTbUODZ_XmBvry7-nz5obv-9P7j5dvrznEla6f0pJgaqZDUKqHniU_zMDCi6DBSJntnJSdS6okLKVxPZuocVRzGfmSNBH6BXp3mto2-rVCqWXxxEIKNkNZiGNOSEsp71dCX_6A3ac2x_c4wLnlPBqWHRrET5XIqJcNs9tkvbTVDidmUMyflTFPOHJUzojW9uB-9jgtMv1t-SdUAfgJKK8Ud5D9v_2fsT0V9ppY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2353609789</pqid></control><display><type>article</type><title>Elevated circulating levels of secreted frizzled-related protein 4 in relation to insulin resistance and androgens in women with polycystic ovary syndrome</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Bicer, M. ; Alarslan, P. ; Guler, A. ; Demir, I. ; Aslanipour, B. ; Calan, M.</creator><creatorcontrib>Bicer, M. ; Alarslan, P. ; Guler, A. ; Demir, I. ; Aslanipour, B. ; Calan, M.</creatorcontrib><description>Purpose
Secreted frizzled-related protein 4 (SFRP4) is an adipokine involving in apoptotic process during ovulation and energy metabolism. Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder associated with insulin resistance and impaired oocyte maturation as well as apoptotic dysfunctions through oocyte development. Our aim was to determine whether there was an alteration in levels of SFRP4 and if there was an association between metabolic or hormonal parameters and SFRP4 in women with PCOS.
Methods
We enrolled 80 subjects with PCOS and 80 age- and body mass index (BMI)-matched subjects with normal menstrual cycle into current case–control study. Metabolic and hormonal parameters of enrolled subjects were determined. Circulating SFRP4 levels were measured with ELISA method.
Results
We found that circulating SFRP4 levels were elevated in women with PCOS with respect to controls (5.87 ± 1.91 vs. 3.72 ± 1.29 ng/ml,
P
< 0.001). We also found a positive association between SFRP4 and insulin resistance, androgens, ovarian follicular number or ovarian volume in women with PCOS. Binary logistic regression analysis revealed that subjects with the highest tertile of SFPR4 levels displayed increased possibility of having PCOS risk compared to those subjects with the lowest tertile of SFRP4 levels.
Conclusions
Increased SFRP4 levels were not only associated with higher possibility of having PCOS but also related to insulin resistance, hyperandrogenism, ovarian follicular number and ovarian volume, suggesting that SFPR4 could be a player in different pathophysiologic pathways of PCOS.</description><identifier>ISSN: 1720-8386</identifier><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-019-01108-4</identifier><identifier>PMID: 31486991</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Androgens ; Androgens - blood ; Apoptosis ; Body Mass Index ; Case-Control Studies ; Endocrinology ; Energy metabolism ; Female ; Frizzled protein ; Frizzled-related protein ; Humans ; Hyperandrogenism - blood ; Insulin ; Insulin resistance ; Insulin Resistance - physiology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Menstrual cycle ; Metabolic Diseases ; Metabolic disorders ; Metabolism ; Original Article ; Ovulation ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Proto-Oncogene Proteins - blood ; Young Adult</subject><ispartof>Journal of endocrinological investigation, 2020-03, Vol.43 (3), p.305-313</ispartof><rights>Italian Society of Endocrinology (SIE) 2019</rights><rights>2019© Italian Society of Endocrinology (SIE) 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-78d727b1451a748fd3df9920719b1256ca530558d3454c60f1cc173eb6b2df9e3</citedby><cites>FETCH-LOGICAL-c375t-78d727b1451a748fd3df9920719b1256ca530558d3454c60f1cc173eb6b2df9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-019-01108-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-019-01108-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31486991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bicer, M.</creatorcontrib><creatorcontrib>Alarslan, P.</creatorcontrib><creatorcontrib>Guler, A.</creatorcontrib><creatorcontrib>Demir, I.</creatorcontrib><creatorcontrib>Aslanipour, B.</creatorcontrib><creatorcontrib>Calan, M.</creatorcontrib><title>Elevated circulating levels of secreted frizzled-related protein 4 in relation to insulin resistance and androgens in women with polycystic ovary syndrome</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Purpose
Secreted frizzled-related protein 4 (SFRP4) is an adipokine involving in apoptotic process during ovulation and energy metabolism. Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder associated with insulin resistance and impaired oocyte maturation as well as apoptotic dysfunctions through oocyte development. Our aim was to determine whether there was an alteration in levels of SFRP4 and if there was an association between metabolic or hormonal parameters and SFRP4 in women with PCOS.
Methods
We enrolled 80 subjects with PCOS and 80 age- and body mass index (BMI)-matched subjects with normal menstrual cycle into current case–control study. Metabolic and hormonal parameters of enrolled subjects were determined. Circulating SFRP4 levels were measured with ELISA method.
Results
We found that circulating SFRP4 levels were elevated in women with PCOS with respect to controls (5.87 ± 1.91 vs. 3.72 ± 1.29 ng/ml,
P
< 0.001). We also found a positive association between SFRP4 and insulin resistance, androgens, ovarian follicular number or ovarian volume in women with PCOS. Binary logistic regression analysis revealed that subjects with the highest tertile of SFPR4 levels displayed increased possibility of having PCOS risk compared to those subjects with the lowest tertile of SFRP4 levels.
Conclusions
Increased SFRP4 levels were not only associated with higher possibility of having PCOS but also related to insulin resistance, hyperandrogenism, ovarian follicular number and ovarian volume, suggesting that SFPR4 could be a player in different pathophysiologic pathways of PCOS.</description><subject>Adult</subject><subject>Androgens</subject><subject>Androgens - blood</subject><subject>Apoptosis</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>Endocrinology</subject><subject>Energy metabolism</subject><subject>Female</subject><subject>Frizzled protein</subject><subject>Frizzled-related protein</subject><subject>Humans</subject><subject>Hyperandrogenism - blood</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menstrual cycle</subject><subject>Metabolic Diseases</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Original Article</subject><subject>Ovulation</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Proto-Oncogene Proteins - blood</subject><subject>Young Adult</subject><issn>1720-8386</issn><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuOFSEQhonROOPoC7gwJG7ctHJt6KWZjJdkEje6JjRdfWRCwxHoMWcexaeVPme8xIWLKoqqrwoqP0LPKXlNCVFviiA91R2hQzNKdCceoHOqGOk01_3Dv-Iz9KSUG0K44lo9RmecCt0PAz1HP64C3NoKE3Y-uzXY6uMOtxyEgtOMC7gMW3nO_u4uwNRlCEd-n1MFH7HAzR2TPkVcU7uWNRxzxZdqowNs47RZTjuIZeO_pwWa9_Ur3qdwcIdSvcPp1uYDLoeNXOApejTbUODZ_XmBvry7-nz5obv-9P7j5dvrznEla6f0pJgaqZDUKqHniU_zMDCi6DBSJntnJSdS6okLKVxPZuocVRzGfmSNBH6BXp3mto2-rVCqWXxxEIKNkNZiGNOSEsp71dCX_6A3ac2x_c4wLnlPBqWHRrET5XIqJcNs9tkvbTVDidmUMyflTFPOHJUzojW9uB-9jgtMv1t-SdUAfgJKK8Ud5D9v_2fsT0V9ppY</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Bicer, M.</creator><creator>Alarslan, P.</creator><creator>Guler, A.</creator><creator>Demir, I.</creator><creator>Aslanipour, B.</creator><creator>Calan, M.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200301</creationdate><title>Elevated circulating levels of secreted frizzled-related protein 4 in relation to insulin resistance and androgens in women with polycystic ovary syndrome</title><author>Bicer, M. ; Alarslan, P. ; Guler, A. ; Demir, I. ; Aslanipour, B. ; Calan, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-78d727b1451a748fd3df9920719b1256ca530558d3454c60f1cc173eb6b2df9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Androgens</topic><topic>Androgens - blood</topic><topic>Apoptosis</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>Endocrinology</topic><topic>Energy metabolism</topic><topic>Female</topic><topic>Frizzled protein</topic><topic>Frizzled-related protein</topic><topic>Humans</topic><topic>Hyperandrogenism - blood</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menstrual cycle</topic><topic>Metabolic Diseases</topic><topic>Metabolic disorders</topic><topic>Metabolism</topic><topic>Original Article</topic><topic>Ovulation</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Proto-Oncogene Proteins - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bicer, M.</creatorcontrib><creatorcontrib>Alarslan, P.</creatorcontrib><creatorcontrib>Guler, A.</creatorcontrib><creatorcontrib>Demir, I.</creatorcontrib><creatorcontrib>Aslanipour, B.</creatorcontrib><creatorcontrib>Calan, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bicer, M.</au><au>Alarslan, P.</au><au>Guler, A.</au><au>Demir, I.</au><au>Aslanipour, B.</au><au>Calan, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated circulating levels of secreted frizzled-related protein 4 in relation to insulin resistance and androgens in women with polycystic ovary syndrome</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>43</volume><issue>3</issue><spage>305</spage><epage>313</epage><pages>305-313</pages><issn>1720-8386</issn><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Purpose
Secreted frizzled-related protein 4 (SFRP4) is an adipokine involving in apoptotic process during ovulation and energy metabolism. Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder associated with insulin resistance and impaired oocyte maturation as well as apoptotic dysfunctions through oocyte development. Our aim was to determine whether there was an alteration in levels of SFRP4 and if there was an association between metabolic or hormonal parameters and SFRP4 in women with PCOS.
Methods
We enrolled 80 subjects with PCOS and 80 age- and body mass index (BMI)-matched subjects with normal menstrual cycle into current case–control study. Metabolic and hormonal parameters of enrolled subjects were determined. Circulating SFRP4 levels were measured with ELISA method.
Results
We found that circulating SFRP4 levels were elevated in women with PCOS with respect to controls (5.87 ± 1.91 vs. 3.72 ± 1.29 ng/ml,
P
< 0.001). We also found a positive association between SFRP4 and insulin resistance, androgens, ovarian follicular number or ovarian volume in women with PCOS. Binary logistic regression analysis revealed that subjects with the highest tertile of SFPR4 levels displayed increased possibility of having PCOS risk compared to those subjects with the lowest tertile of SFRP4 levels.
Conclusions
Increased SFRP4 levels were not only associated with higher possibility of having PCOS but also related to insulin resistance, hyperandrogenism, ovarian follicular number and ovarian volume, suggesting that SFPR4 could be a player in different pathophysiologic pathways of PCOS.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31486991</pmid><doi>10.1007/s40618-019-01108-4</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of endocrinological investigation, 2020-03, Vol.43 (3), p.305-313 |
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| language | eng |
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| subjects | Adult Androgens Androgens - blood Apoptosis Body Mass Index Case-Control Studies Endocrinology Energy metabolism Female Frizzled protein Frizzled-related protein Humans Hyperandrogenism - blood Insulin Insulin resistance Insulin Resistance - physiology Internal Medicine Medicine Medicine & Public Health Menstrual cycle Metabolic Diseases Metabolic disorders Metabolism Original Article Ovulation Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Proto-Oncogene Proteins - blood Young Adult |
| title | Elevated circulating levels of secreted frizzled-related protein 4 in relation to insulin resistance and androgens in women with polycystic ovary syndrome |
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