Evaluation of Anti-inflammatory Efficacy of RA-V: a Natural Cyclopeptide
Inflammation occurs in a cascade reaction to cause damage in the tissues. It involves increased expression of oxidants and cytokines in the injured tissues. Peptides are chosen for the development of alternate and more selective anti-inflammatory therapies. They are highly specific and significant d...
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| Veröffentlicht in: | Applied biochemistry and biotechnology 2020-02, Vol.190 (2), p.732-744 |
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| creator | S, Rupachandra S., Porkodi Joann, M. Davina S., Jagadeeshwari |
| description | Inflammation occurs in a cascade reaction to cause damage in the tissues. It involves increased expression of oxidants and cytokines in the injured tissues. Peptides are chosen for the development of alternate and more selective anti-inflammatory therapies. They are highly specific and significant due to their low molecular weight, simple structure, low antigenicity, and low toxicity. They are capable of easy absorption through different routes of administration and rapid clearance from the system. Plant-derived cyclic peptides have great therapeutic values. Peptides from
Rubia cordifolia
exhibit potent anti-inflammatory, anti-diabetic, anti-arthritic, and antioxidant properties. Cyclotides are small peptides isolated from plants with a cyclic backbone and disulfide bonds. The cyclic cystine knot structure of the cyclic peptide makes them resistant to chemical, enzymatic, and thermal conditions. They are isolated from
Rubiaceae
,
Violaceae
, and
Cucurbitaceae
plant families. The overall aim of this study is to evaluate the biological efficacy of the cyclopeptide, RA-V (deoxybouvardin) isolated from
Rubia cordifolia
. |
| doi_str_mv | 10.1007/s12010-019-03124-9 |
| format | Article |
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Rubia cordifolia
exhibit potent anti-inflammatory, anti-diabetic, anti-arthritic, and antioxidant properties. Cyclotides are small peptides isolated from plants with a cyclic backbone and disulfide bonds. The cyclic cystine knot structure of the cyclic peptide makes them resistant to chemical, enzymatic, and thermal conditions. They are isolated from
Rubiaceae
,
Violaceae
, and
Cucurbitaceae
plant families. The overall aim of this study is to evaluate the biological efficacy of the cyclopeptide, RA-V (deoxybouvardin) isolated from
Rubia cordifolia
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Rubia cordifolia
exhibit potent anti-inflammatory, anti-diabetic, anti-arthritic, and antioxidant properties. Cyclotides are small peptides isolated from plants with a cyclic backbone and disulfide bonds. The cyclic cystine knot structure of the cyclic peptide makes them resistant to chemical, enzymatic, and thermal conditions. They are isolated from
Rubiaceae
,
Violaceae
, and
Cucurbitaceae
plant families. The overall aim of this study is to evaluate the biological efficacy of the cyclopeptide, RA-V (deoxybouvardin) isolated from
Rubia cordifolia
.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antigenicity</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Biochemistry</subject><subject>Biotechnology</subject><subject>Cascade chemical reactions</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cystine</subject><subject>Cytokines</subject><subject>Diabetes mellitus</subject><subject>Disulfide bonds</subject><subject>Inflammation</subject><subject>Low molecular weights</subject><subject>Mice</subject><subject>Molecular structure</subject><subject>Molecular weight</subject><subject>Organic chemistry</subject><subject>Oxidants</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidizing agents</subject><subject>Peptides</subject><subject>Peptides, Cyclic - pharmacology</subject><subject>Plants</subject><subject>Rubia - chemistry</subject><subject>Rubia cordifolia</subject><subject>Toxicity</subject><issn>0273-2289</issn><issn>1559-0291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6BzxIwYuX6kzablpvy7J-wKIg6jVM20S69GNNWqH_3tSuCh68ZEjmmTfvvIydIlwigLiyyAHBB0x8CJCHfrLHphhF7soT3GdT4CLwOY-TCTuydgOAPI7EIZsEGMbD-5TdrT6o7KgtmtprtLeo28Ival1SVVHbmN5baV1klPVD92nhv1575D1Q2xkqvWWflc1WbdsiV8fsQFNp1cmuztjLzep5eeevH2_vl4u1n4XIW3eCTsC5z9M80yC0QtAcKVKoeawojSica6QgFVxnQhDME-Kxzp3jucp5MGMXo-7WNO-dsq2sCpupsqRaNZ2Vbq0wmgcCwaHnf9BN05nauRuoQAAiHwT5SGWmsdYoLbemqMj0EkEOOcsxZ-lyll85y8QNne2ku7RS-c_Id7AOCEbAulb9pszv3__IfgIj_Ya4</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>S, Rupachandra</creator><creator>S., Porkodi</creator><creator>Joann, M. 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Davina ; S., Jagadeeshwari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-c40f90007dbdcf07fe10f21a5e1f28eab5a46f1a3b72fc77a069a28fd1486ed23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antigenicity</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Biochemistry</topic><topic>Biotechnology</topic><topic>Cascade chemical reactions</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Cystine</topic><topic>Cytokines</topic><topic>Diabetes mellitus</topic><topic>Disulfide bonds</topic><topic>Inflammation</topic><topic>Low molecular weights</topic><topic>Mice</topic><topic>Molecular structure</topic><topic>Molecular weight</topic><topic>Organic chemistry</topic><topic>Oxidants</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidizing agents</topic><topic>Peptides</topic><topic>Peptides, Cyclic - pharmacology</topic><topic>Plants</topic><topic>Rubia - chemistry</topic><topic>Rubia cordifolia</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>S, Rupachandra</creatorcontrib><creatorcontrib>S., Porkodi</creatorcontrib><creatorcontrib>Joann, M. 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Davina</au><au>S., Jagadeeshwari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Anti-inflammatory Efficacy of RA-V: a Natural Cyclopeptide</atitle><jtitle>Applied biochemistry and biotechnology</jtitle><stitle>Appl Biochem Biotechnol</stitle><addtitle>Appl Biochem Biotechnol</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>190</volume><issue>2</issue><spage>732</spage><epage>744</epage><pages>732-744</pages><issn>0273-2289</issn><eissn>1559-0291</eissn><abstract>Inflammation occurs in a cascade reaction to cause damage in the tissues. It involves increased expression of oxidants and cytokines in the injured tissues. Peptides are chosen for the development of alternate and more selective anti-inflammatory therapies. They are highly specific and significant due to their low molecular weight, simple structure, low antigenicity, and low toxicity. They are capable of easy absorption through different routes of administration and rapid clearance from the system. Plant-derived cyclic peptides have great therapeutic values. Peptides from
Rubia cordifolia
exhibit potent anti-inflammatory, anti-diabetic, anti-arthritic, and antioxidant properties. Cyclotides are small peptides isolated from plants with a cyclic backbone and disulfide bonds. The cyclic cystine knot structure of the cyclic peptide makes them resistant to chemical, enzymatic, and thermal conditions. They are isolated from
Rubiaceae
,
Violaceae
, and
Cucurbitaceae
plant families. The overall aim of this study is to evaluate the biological efficacy of the cyclopeptide, RA-V (deoxybouvardin) isolated from
Rubia cordifolia
.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31482289</pmid><doi>10.1007/s12010-019-03124-9</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-1446-1313</orcidid></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - pharmacology Antigenicity Antioxidants Antioxidants - pharmacology Biochemistry Biotechnology Cascade chemical reactions Chemistry Chemistry and Materials Science Cystine Cytokines Diabetes mellitus Disulfide bonds Inflammation Low molecular weights Mice Molecular structure Molecular weight Organic chemistry Oxidants Oxidative Stress - drug effects Oxidizing agents Peptides Peptides, Cyclic - pharmacology Plants Rubia - chemistry Rubia cordifolia Toxicity |
| title | Evaluation of Anti-inflammatory Efficacy of RA-V: a Natural Cyclopeptide |
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