VE-cadherin regulates migration inhibitory factor synthesis and release

Objective Vascular endothelial (VE)-cadherin-mediated adherens junction is critical to maintain endothelial integrity. Besides its role of homophilic intercellular adhesion, VE-cadherin also has a role of outside-in signaling with functional consequences for vascular physiology. However, the nature...

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Veröffentlicht in:	Inflammation research 2019-10, Vol.68 (10), p.877-887
Hauptverfasser:	Li, Ranran, Li, Lei, Liu, Yiyun, Tang, Yaoqing, Zhang, Ruyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Allergology Animals Antibodies Antibodies, Monoclonal - pharmacology Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism Arrays Biomedical and Life Sciences Biomedicine Blocking antibodies Cadherins Cadherins - genetics Cadherins - immunology Cadherins - metabolism Cell adhesion Cell adhesion & migration Cell culture Chemokines Cytokines Dermatology Disruption Endothelial cells Enzyme-linked immunosorbent assay Gene expression Human Umbilical Vein Endothelial Cells - metabolism Humans Immunoglobulin G Immunology In vivo methods and tests Intramolecular Oxidoreductases - genetics Intramolecular Oxidoreductases - metabolism Kinases Lungs Macrophage migration inhibitory factor Macrophage Migration-Inhibitory Factors - genetics Macrophage Migration-Inhibitory Factors - metabolism Male Mice, Inbred C57BL Neurology Neutralizing Original Research Paper Pharmacology/Toxicology Phosphorylation Rheumatology RNA, Small Interfering - genetics siRNA Synthesis Transfection Umbilical vein
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