The fidelity of cancer cells in PDX models: Characteristics, mechanism and clinical significance

Patient‐derived xenograft (PDX) models are widely used as preclinical cancer models and are considered better than cell culture models in recapitulating the histological features, molecular characteristics and intratumoral heterogeneity (ITH) of human tumors. While the PDX model is commonly accepted...

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Veröffentlicht in:	International journal of cancer 2020-04, Vol.146 (8), p.2078-2088
Hauptverfasser:	Shi, Jiahao, Li, Yongyun, Jia, Renbing, Fan, Xianqun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cell culture Clinical significance Drug Evaluation, Preclinical - methods Drug screening Fidelity Genomic instability Heterografts - drug effects Humans Medical research Mice natural selection Neoplasms - drug therapy Neoplasms - pathology patient‐derived xenograft Phenotypes Precision medicine selection bias Transplantation Transplantation, Heterologous - methods tumor heterogeneity Tumors Xenograft Model Antitumor Assays - methods Xenografts Zebrafish
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