Impact of Treatment-Related Lymphopenia on Immunotherapy for Advanced Non-Small Cell Lung Cancer

The interest in combining radiation therapy (RT) with immunotherapy is increasing. We investigated the significance of lymphopenia in patients receiving immunotherapy for non-small cell lung cancer (NSCLC), and the factors associated with treatment-related lymphopenia, with particular emphasis on RT...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2019-12, Vol.105 (5), p.1065-1073
Hauptverfasser:	Cho, Yeona, Park, Sangjoon, Byun, Hwa Kyung, Lee, Chang Geol, Cho, Jaeho, Hong, Min Hee, Kim, Hye Ryun, Cho, Byoung Chul, Kim, Sinae, Park, Juyoung, Yoon, Hong In
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Agents - therapeutic use Antineoplastic Agents, Immunological - therapeutic use Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - radiotherapy Carcinoma, Non-Small-Cell Lung - therapy Female Humans Immunotherapy - adverse effects Immunotherapy - methods Immunotherapy - mortality Ipilimumab - therapeutic use Lung Neoplasms - mortality Lung Neoplasms - radiotherapy Lung Neoplasms - therapy Lymphocyte Count Lymphopenia - etiology Lymphopenia - mortality Male Middle Aged Nivolumab - therapeutic use Odds Ratio Progression-Free Survival Radiotherapy - adverse effects Retrospective Studies Time Factors
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Zusammenfassung:	The interest in combining radiation therapy (RT) with immunotherapy is increasing. We investigated the significance of lymphopenia in patients receiving immunotherapy for non-small cell lung cancer (NSCLC), and the factors associated with treatment-related lymphopenia, with particular emphasis on RT. In this retrospective single institution study, 268 patients with advanced NSCLC received immunotherapy, of whom 146 received RT. Lymphopenia was defined as an absolute lymphocyte count
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2019.08.047