Derivative of 5-cyano-6-phenylpyrimidin antagonizes ABCB1- and ABCG2-mediated multidrug resistance

Multidrug resistance (MDR) lead to inadequate response to chemotherapy and cause failure in cancer treatment. One of the targeted approaches to overcome MDR in cancer cells is interfering or inhibiting ATP binding cassette (ABC) transporters. Among all members in ABC transporters superfamily, ABCB1...

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Veröffentlicht in:	European journal of pharmacology 2019-11, Vol.863, p.172611-172611, Article 172611
Hauptverfasser:	Wang, Jing-Quan, Wang, Bo, Lei, Zi-Ning, Teng, Qiu-Xu, Li, Jonathan Y., Zhang, Wei, Ji, Ning, Cai, Chao-Yun, Ma, Li-Ying, Liu, Hong-Min, Chen, Zhe-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Cyano-6-phenylpyrimidin derivative ABCB1 ABCG2 ATP Binding Cassette Transporter, Subfamily B - chemistry ATP Binding Cassette Transporter, Subfamily B - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 - chemistry ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism Cell Line, Tumor Drug Resistance, Multiple - drug effects Humans Intracellular Space - drug effects Intracellular Space - metabolism MDR Mitoxantrone - metabolism Molecular Docking Simulation Paclitaxel - metabolism Protein Conformation Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - metabolism Pyrimidines - pharmacology Reversal
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