Fetal coenzyme Q10 deficiency in intrahepatic cholestasis of pregnancy
•A significant decrease in plasma Coenzyme Q10 (CoQ10) in women with intrahepatic cholestasis of pregnancy (ICP), was observed.•Levels of CoQ10 in cord blood from ICP mothers remain unchanged with respect to controls.•The recognition of CoQ10 deficiency is important in ICP since it could be the star...
Gespeichert in:
| Veröffentlicht in: | Clinics and research in hepatology and gastroenterology 2020-06, Vol.44 (3), p.368-374 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 374 |
|---|---|
| container_issue | 3 |
| container_start_page | 368 |
| container_title | Clinics and research in hepatology and gastroenterology |
| container_volume | 44 |
| creator | Martinefski, Manuela Romina Cocucci, Silvina Ema Di Carlo, María Beatriz Vega, Hilda Ruda Lucangioli, Silvia Edith Perazzi, Beatriz Elizabeth Tripodi, Valeria Paula |
| description | •A significant decrease in plasma Coenzyme Q10 (CoQ10) in women with intrahepatic cholestasis of pregnancy (ICP), was observed.•Levels of CoQ10 in cord blood from ICP mothers remain unchanged with respect to controls.•The recognition of CoQ10 deficiency is important in ICP since it could be the starting point for a new and safe intervention strategy based on CoQ10 maternal supplementation to prevent the risk of oxidative stress in ICP.
Intrahepatic cholestasis of pregnancy (ICP) is considered a high-risk condition because it may have serious consequences for the fetus health. ICP is characterized by the accumulation of bile acids in maternal serum which contribute to an imbalance between the production of reactive oxygen species and the antioxidant defenses increasing the oxidative stress experienced by the fetus. Previously, it was reported a significant decrease in plasma coenzyme Q10 (CoQ10) in women with ICP. CoQ10 is a redox substance integrated in the mitochondrial respiratory chain and is recognized as a potent antioxidant playing an intrinsic role against oxidative damage. The objective of the present study was to investigate the levels of CoQ10 in umbilical cord blood during normal pregnancy and in those complicated with ICP, all of them compared to the maternal ones.
CoQ10 levels and bile acid levels in maternal and umbilical cord blood levels during normal pregnancies (n=23) and in those complicated with ICP (n=13), were investigated.
A significant decrease in neonate CoQ10 levels corrected by cholesterol (0.105±0.010 vs. 0.069±0.011, P |
| doi_str_mv | 10.1016/j.clinre.2019.07.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2283996562</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2210740119301718</els_id><sourcerecordid>2283996562</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-5e2e0f6903ad16bf8f7275ddd69a51c0178ed1d0882d3eff71895138d891c1b43</originalsourceid><addsrcrecordid>eNp9kMFKxDAQQIMoKuofiPToZetM0jbpRRBxVRBEUPAWsslEs3TbNekK69cbXfXoEJg5vMnMPMaOEUoEbM7mpe1CH6nkgG0JsgRottg-5wgTWeHz9l8NuMeOUppDjqoGJXGX7QmspKyF2GfTKY2mK-xA_cd6QcUDQuHIBxuot-si9PmN0bzS0ozBFvZ16CiNJoVUDL5YRnrpTQYP2Y43XaKjn3zAnqZXj5c3k7v769vLi7uJFQ0fJzVxAt-0IIzDZuaVl1zWzrmmNTVaQKnIoQOluBPkvUTV1iiUUy1anFXigJ1u_l3G4W2VN9GLkCx1nelpWCXNuRJt29QNz2i1QW0cUork9TKGhYlrjaC_JOq53kjUXxI1SJ0l5raTnwmr2YLcX9OvsgycbwDKd74Hijp9yyIXItlRuyH8P-ETA8WD8g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2283996562</pqid></control><display><type>article</type><title>Fetal coenzyme Q10 deficiency in intrahepatic cholestasis of pregnancy</title><source>Access via ScienceDirect (Elsevier)</source><creator>Martinefski, Manuela Romina ; Cocucci, Silvina Ema ; Di Carlo, María Beatriz ; Vega, Hilda Ruda ; Lucangioli, Silvia Edith ; Perazzi, Beatriz Elizabeth ; Tripodi, Valeria Paula</creator><creatorcontrib>Martinefski, Manuela Romina ; Cocucci, Silvina Ema ; Di Carlo, María Beatriz ; Vega, Hilda Ruda ; Lucangioli, Silvia Edith ; Perazzi, Beatriz Elizabeth ; Tripodi, Valeria Paula</creatorcontrib><description>•A significant decrease in plasma Coenzyme Q10 (CoQ10) in women with intrahepatic cholestasis of pregnancy (ICP), was observed.•Levels of CoQ10 in cord blood from ICP mothers remain unchanged with respect to controls.•The recognition of CoQ10 deficiency is important in ICP since it could be the starting point for a new and safe intervention strategy based on CoQ10 maternal supplementation to prevent the risk of oxidative stress in ICP.
Intrahepatic cholestasis of pregnancy (ICP) is considered a high-risk condition because it may have serious consequences for the fetus health. ICP is characterized by the accumulation of bile acids in maternal serum which contribute to an imbalance between the production of reactive oxygen species and the antioxidant defenses increasing the oxidative stress experienced by the fetus. Previously, it was reported a significant decrease in plasma coenzyme Q10 (CoQ10) in women with ICP. CoQ10 is a redox substance integrated in the mitochondrial respiratory chain and is recognized as a potent antioxidant playing an intrinsic role against oxidative damage. The objective of the present study was to investigate the levels of CoQ10 in umbilical cord blood during normal pregnancy and in those complicated with ICP, all of them compared to the maternal ones.
CoQ10 levels and bile acid levels in maternal and umbilical cord blood levels during normal pregnancies (n=23) and in those complicated with ICP (n=13), were investigated.
A significant decrease in neonate CoQ10 levels corrected by cholesterol (0.105±0.010 vs. 0.069±0.011, P<0.05, normal pregnancy vs. ICP, respectively), together with an increase of total serum bile acids (2.10±0.02 vs. 7.60±2.30, P<0.05, normal pregnancy vs. ICP, respectively) was observed.
A fetus from an ICP mother is exposed to a greater risk derived from oxidative damage. The recognition of CoQ10 deficiency is important since it could be the starting point for a new and safe intervention strategy which can establish CoQ10 as a promising candidate to prevent the risk of oxidative stress.</description><identifier>ISSN: 2210-7401</identifier><identifier>EISSN: 2210-741X</identifier><identifier>DOI: 10.1016/j.clinre.2019.07.006</identifier><identifier>PMID: 31477533</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Bile acids ; Cord blood ; Oxidative stress ; Pregnancy cholestasis ; Ubiquinone</subject><ispartof>Clinics and research in hepatology and gastroenterology, 2020-06, Vol.44 (3), p.368-374</ispartof><rights>2019 Elsevier Masson SAS</rights><rights>Copyright © 2019 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-5e2e0f6903ad16bf8f7275ddd69a51c0178ed1d0882d3eff71895138d891c1b43</citedby><cites>FETCH-LOGICAL-c362t-5e2e0f6903ad16bf8f7275ddd69a51c0178ed1d0882d3eff71895138d891c1b43</cites><orcidid>0000-0003-2106-7127 ; 0000-0002-4501-3783</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinre.2019.07.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31477533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martinefski, Manuela Romina</creatorcontrib><creatorcontrib>Cocucci, Silvina Ema</creatorcontrib><creatorcontrib>Di Carlo, María Beatriz</creatorcontrib><creatorcontrib>Vega, Hilda Ruda</creatorcontrib><creatorcontrib>Lucangioli, Silvia Edith</creatorcontrib><creatorcontrib>Perazzi, Beatriz Elizabeth</creatorcontrib><creatorcontrib>Tripodi, Valeria Paula</creatorcontrib><title>Fetal coenzyme Q10 deficiency in intrahepatic cholestasis of pregnancy</title><title>Clinics and research in hepatology and gastroenterology</title><addtitle>Clin Res Hepatol Gastroenterol</addtitle><description>•A significant decrease in plasma Coenzyme Q10 (CoQ10) in women with intrahepatic cholestasis of pregnancy (ICP), was observed.•Levels of CoQ10 in cord blood from ICP mothers remain unchanged with respect to controls.•The recognition of CoQ10 deficiency is important in ICP since it could be the starting point for a new and safe intervention strategy based on CoQ10 maternal supplementation to prevent the risk of oxidative stress in ICP.
Intrahepatic cholestasis of pregnancy (ICP) is considered a high-risk condition because it may have serious consequences for the fetus health. ICP is characterized by the accumulation of bile acids in maternal serum which contribute to an imbalance between the production of reactive oxygen species and the antioxidant defenses increasing the oxidative stress experienced by the fetus. Previously, it was reported a significant decrease in plasma coenzyme Q10 (CoQ10) in women with ICP. CoQ10 is a redox substance integrated in the mitochondrial respiratory chain and is recognized as a potent antioxidant playing an intrinsic role against oxidative damage. The objective of the present study was to investigate the levels of CoQ10 in umbilical cord blood during normal pregnancy and in those complicated with ICP, all of them compared to the maternal ones.
CoQ10 levels and bile acid levels in maternal and umbilical cord blood levels during normal pregnancies (n=23) and in those complicated with ICP (n=13), were investigated.
A significant decrease in neonate CoQ10 levels corrected by cholesterol (0.105±0.010 vs. 0.069±0.011, P<0.05, normal pregnancy vs. ICP, respectively), together with an increase of total serum bile acids (2.10±0.02 vs. 7.60±2.30, P<0.05, normal pregnancy vs. ICP, respectively) was observed.
A fetus from an ICP mother is exposed to a greater risk derived from oxidative damage. The recognition of CoQ10 deficiency is important since it could be the starting point for a new and safe intervention strategy which can establish CoQ10 as a promising candidate to prevent the risk of oxidative stress.</description><subject>Bile acids</subject><subject>Cord blood</subject><subject>Oxidative stress</subject><subject>Pregnancy cholestasis</subject><subject>Ubiquinone</subject><issn>2210-7401</issn><issn>2210-741X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMFKxDAQQIMoKuofiPToZetM0jbpRRBxVRBEUPAWsslEs3TbNekK69cbXfXoEJg5vMnMPMaOEUoEbM7mpe1CH6nkgG0JsgRottg-5wgTWeHz9l8NuMeOUppDjqoGJXGX7QmspKyF2GfTKY2mK-xA_cd6QcUDQuHIBxuot-si9PmN0bzS0ozBFvZ16CiNJoVUDL5YRnrpTQYP2Y43XaKjn3zAnqZXj5c3k7v769vLi7uJFQ0fJzVxAt-0IIzDZuaVl1zWzrmmNTVaQKnIoQOluBPkvUTV1iiUUy1anFXigJ1u_l3G4W2VN9GLkCx1nelpWCXNuRJt29QNz2i1QW0cUork9TKGhYlrjaC_JOq53kjUXxI1SJ0l5raTnwmr2YLcX9OvsgycbwDKd74Hijp9yyIXItlRuyH8P-ETA8WD8g</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Martinefski, Manuela Romina</creator><creator>Cocucci, Silvina Ema</creator><creator>Di Carlo, María Beatriz</creator><creator>Vega, Hilda Ruda</creator><creator>Lucangioli, Silvia Edith</creator><creator>Perazzi, Beatriz Elizabeth</creator><creator>Tripodi, Valeria Paula</creator><general>Elsevier Masson SAS</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2106-7127</orcidid><orcidid>https://orcid.org/0000-0002-4501-3783</orcidid></search><sort><creationdate>20200601</creationdate><title>Fetal coenzyme Q10 deficiency in intrahepatic cholestasis of pregnancy</title><author>Martinefski, Manuela Romina ; Cocucci, Silvina Ema ; Di Carlo, María Beatriz ; Vega, Hilda Ruda ; Lucangioli, Silvia Edith ; Perazzi, Beatriz Elizabeth ; Tripodi, Valeria Paula</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-5e2e0f6903ad16bf8f7275ddd69a51c0178ed1d0882d3eff71895138d891c1b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bile acids</topic><topic>Cord blood</topic><topic>Oxidative stress</topic><topic>Pregnancy cholestasis</topic><topic>Ubiquinone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martinefski, Manuela Romina</creatorcontrib><creatorcontrib>Cocucci, Silvina Ema</creatorcontrib><creatorcontrib>Di Carlo, María Beatriz</creatorcontrib><creatorcontrib>Vega, Hilda Ruda</creatorcontrib><creatorcontrib>Lucangioli, Silvia Edith</creatorcontrib><creatorcontrib>Perazzi, Beatriz Elizabeth</creatorcontrib><creatorcontrib>Tripodi, Valeria Paula</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinics and research in hepatology and gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martinefski, Manuela Romina</au><au>Cocucci, Silvina Ema</au><au>Di Carlo, María Beatriz</au><au>Vega, Hilda Ruda</au><au>Lucangioli, Silvia Edith</au><au>Perazzi, Beatriz Elizabeth</au><au>Tripodi, Valeria Paula</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetal coenzyme Q10 deficiency in intrahepatic cholestasis of pregnancy</atitle><jtitle>Clinics and research in hepatology and gastroenterology</jtitle><addtitle>Clin Res Hepatol Gastroenterol</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>44</volume><issue>3</issue><spage>368</spage><epage>374</epage><pages>368-374</pages><issn>2210-7401</issn><eissn>2210-741X</eissn><abstract>•A significant decrease in plasma Coenzyme Q10 (CoQ10) in women with intrahepatic cholestasis of pregnancy (ICP), was observed.•Levels of CoQ10 in cord blood from ICP mothers remain unchanged with respect to controls.•The recognition of CoQ10 deficiency is important in ICP since it could be the starting point for a new and safe intervention strategy based on CoQ10 maternal supplementation to prevent the risk of oxidative stress in ICP.
Intrahepatic cholestasis of pregnancy (ICP) is considered a high-risk condition because it may have serious consequences for the fetus health. ICP is characterized by the accumulation of bile acids in maternal serum which contribute to an imbalance between the production of reactive oxygen species and the antioxidant defenses increasing the oxidative stress experienced by the fetus. Previously, it was reported a significant decrease in plasma coenzyme Q10 (CoQ10) in women with ICP. CoQ10 is a redox substance integrated in the mitochondrial respiratory chain and is recognized as a potent antioxidant playing an intrinsic role against oxidative damage. The objective of the present study was to investigate the levels of CoQ10 in umbilical cord blood during normal pregnancy and in those complicated with ICP, all of them compared to the maternal ones.
CoQ10 levels and bile acid levels in maternal and umbilical cord blood levels during normal pregnancies (n=23) and in those complicated with ICP (n=13), were investigated.
A significant decrease in neonate CoQ10 levels corrected by cholesterol (0.105±0.010 vs. 0.069±0.011, P<0.05, normal pregnancy vs. ICP, respectively), together with an increase of total serum bile acids (2.10±0.02 vs. 7.60±2.30, P<0.05, normal pregnancy vs. ICP, respectively) was observed.
A fetus from an ICP mother is exposed to a greater risk derived from oxidative damage. The recognition of CoQ10 deficiency is important since it could be the starting point for a new and safe intervention strategy which can establish CoQ10 as a promising candidate to prevent the risk of oxidative stress.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>31477533</pmid><doi>10.1016/j.clinre.2019.07.006</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2106-7127</orcidid><orcidid>https://orcid.org/0000-0002-4501-3783</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2210-7401 |
| ispartof | Clinics and research in hepatology and gastroenterology, 2020-06, Vol.44 (3), p.368-374 |
| issn | 2210-7401 2210-741X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2283996562 |
| source | Access via ScienceDirect (Elsevier) |
| subjects | Bile acids Cord blood Oxidative stress Pregnancy cholestasis Ubiquinone |
| title | Fetal coenzyme Q10 deficiency in intrahepatic cholestasis of pregnancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T12%3A53%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fetal%20coenzyme%20Q10%20deficiency%20in%20intrahepatic%20cholestasis%20of%20pregnancy&rft.jtitle=Clinics%20and%20research%20in%20hepatology%20and%20gastroenterology&rft.au=Martinefski,%20Manuela%20Romina&rft.date=2020-06-01&rft.volume=44&rft.issue=3&rft.spage=368&rft.epage=374&rft.pages=368-374&rft.issn=2210-7401&rft.eissn=2210-741X&rft_id=info:doi/10.1016/j.clinre.2019.07.006&rft_dat=%3Cproquest_cross%3E2283996562%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2283996562&rft_id=info:pmid/31477533&rft_els_id=S2210740119301718&rfr_iscdi=true |