A Novel Tissue‐Based Liver–Kidney‐on‐a‐Chip Can Mimic Liver Tropism of Extracellular Vesicles Derived from Breast Cancer Cells

Extracellular vesicles (EVs) from cancer cells remodel distant organs to promote metastasis in vivo. A biomimetic microsystem may compensate costly and time‐consuming animal models to accelerate the study of EV organotropism. A tissue‐based liver–kidney‐on‐a‐chip is developed with precision‐cut tiss...

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Veröffentlicht in:	Biotechnology journal 2020-02, Vol.15 (2), p.e1900107-n/a
Hauptverfasser:	Tian, Hongzhu, Pang, Jiushen, Qin, Kairong, Yuan, Weimo, Kong, Jing, Ma, Hongjuan, He, Junzhou, Yang, Xuesong, Luo, Yong, Lu, Yao, Lin, Bingcheng, Liu, Tingjiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomimetics breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology CXCL12/CXCR4 Extracellular Vesicles - pathology extraxcellular vesicles Female Heterocyclic Compounds - pharmacology Humans Kidney - pathology Lab-On-A-Chip Devices Liver - pathology liver tropism microfluidic Microfluidics Neoplasm Metastasis Oligonucleotide Array Sequence Analysis Tropism - drug effects
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