$Efficacy and safety of quizartinib in Japanese patients with FLT3-ITD positive relapsed or refractory acute myeloid leukemia in an open-label, phase 2 study$

Efficacy and safety of quizartinib in Japanese patients with FLT3-ITD positive relapsed or refractory acute myeloid leukemia in an open-label, phase 2 study

FMS-like tyrosine kinase 3 ( FLT3 ) internal tandem duplication (ITD) mutations in patients with acute myeloid leukemia (AML) are associated with early relapse and poor survival. This multicenter, single-arm, two-stage phase 2 study (NCT02984995) was conducted to evaluate the efficacy and safety of...

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Veröffentlicht in:	International journal of hematology 2019-12, Vol.110 (6), p.665-674
Hauptverfasser:	Takahashi, Takeshi, Usuki, Kensuke, Matsue, Kosei, Ohno, Hitoshi, Sakura, Toru, Imanaka, Ryota, Murakami, Masato, Ohwada, Shoichi, Takagi, Taiga, Sakajiri, Sakura
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Aged Arrhythmia Benzothiazoles - adverse effects Benzothiazoles - pharmacology Benzothiazoles - therapeutic use Confidence intervals Effectiveness Female Flt3 protein fms-Like Tyrosine Kinase 3 - genetics Hematology Humans Japan Kinases Leukemia Leukemia, Myeloid, Acute - complications Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - mortality Male Medicine Medicine & Public Health Middle Aged Mutation Myeloid leukemia Neutropenia Oncology Original Article Patients Phenylurea Compounds - adverse effects Phenylurea Compounds - pharmacology Phenylurea Compounds - therapeutic use Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase Remission Remission Induction - methods Safety Salvage Therapy - adverse effects Salvage Therapy - methods Salvage Therapy - mortality Survival Treatment Outcome Tyrosine
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