Maternal alcohol consumption and oral clefts: a meta-analysis
Our aim was to evaluate the possible correlation between maternal alcohol consumption during the first trimester and the risk of having an offspring with non-syndromic oral cleft. We electronically searched all published papers from 1950 to 2019 about maternal alcohol consumption and oral clefts in...
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Veröffentlicht in: | British journal of oral & maxillofacial surgery 2019-11, Vol.57 (9), p.839-846 |
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description | Our aim was to evaluate the possible correlation between maternal alcohol consumption during the first trimester and the risk of having an offspring with non-syndromic oral cleft. We electronically searched all published papers from 1950 to 2019 about maternal alcohol consumption and oral clefts in PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Institute for Scientific Information (ISI) databases. Descriptive and quantitative data were extracted from eligible studies for systemic evaluation and meta-analysis. A total of 12 publications met our inclusion criteria, and nine of them presented sufficient data for quantitative analyses. The overall odds ratio of the nine reports was 1.00 (95% CI 0.87 to 1.15) for cleft lip with or without cleft palate (CL/P) and 1.02 (95% CI 0.92 to 1.14) for cleft palate only, indicating no significant difference between drinking and non-drinking mothers in the risk of having a child with a non-syndromic oral cleft. We found no confirmatory evidence for the presence of a dose-response relation between alcohol consumption and increase in the risk of oral cleft. Nevertheless, four of the studies enrolled found significantly increased risk of CL/P among mothers in the groups that consumed the most alcohol. All but one of the four studies suggested a positive correlation between binge drinking and the occurrence of non-syndromic oral cleft. Although we found no concrete correlation between mild alcohol consumption during pregnancy and the occurrence of non-syndromic oral cleft, precautions should still be taken to avoid binge drinking during the first trimester. |
doi_str_mv | 10.1016/j.bjoms.2019.08.013 |
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We electronically searched all published papers from 1950 to 2019 about maternal alcohol consumption and oral clefts in PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Institute for Scientific Information (ISI) databases. Descriptive and quantitative data were extracted from eligible studies for systemic evaluation and meta-analysis. A total of 12 publications met our inclusion criteria, and nine of them presented sufficient data for quantitative analyses. The overall odds ratio of the nine reports was 1.00 (95% CI 0.87 to 1.15) for cleft lip with or without cleft palate (CL/P) and 1.02 (95% CI 0.92 to 1.14) for cleft palate only, indicating no significant difference between drinking and non-drinking mothers in the risk of having a child with a non-syndromic oral cleft. We found no confirmatory evidence for the presence of a dose-response relation between alcohol consumption and increase in the risk of oral cleft. Nevertheless, four of the studies enrolled found significantly increased risk of CL/P among mothers in the groups that consumed the most alcohol. All but one of the four studies suggested a positive correlation between binge drinking and the occurrence of non-syndromic oral cleft. Although we found no concrete correlation between mild alcohol consumption during pregnancy and the occurrence of non-syndromic oral cleft, precautions should still be taken to avoid binge drinking during the first trimester.</description><identifier>ISSN: 0266-4356</identifier><identifier>EISSN: 1532-1940</identifier><identifier>DOI: 10.1016/j.bjoms.2019.08.013</identifier><identifier>PMID: 31473040</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>alcohol ; Alcohol Drinking - adverse effects ; binge drinking ; birth defect ; Case-Control Studies ; Cleft Lip - etiology ; cleft lip and palate ; Cleft Palate - etiology ; craniofacial anomalies ; Dentistry ; Female ; Humans ; Infant, Newborn ; Maternal exposure ; Pregnancy ; Pregnancy Trimester, First ; Prenatal Exposure Delayed Effects ; Risk Factors</subject><ispartof>British journal of oral & maxillofacial surgery, 2019-11, Vol.57 (9), p.839-846</ispartof><rights>2019 The British Association of Oral and Maxillofacial Surgeons</rights><rights>Copyright © 2019 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-5374bf1795d611f9ce87deb4f92080cd15d37e804df84d0a1480603f25c110373</citedby><cites>FETCH-LOGICAL-c359t-5374bf1795d611f9ce87deb4f92080cd15d37e804df84d0a1480603f25c110373</cites><orcidid>0000-0002-1034-5999</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bjoms.2019.08.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31473040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, X.</creatorcontrib><creatorcontrib>Li, J.</creatorcontrib><creatorcontrib>Li, Y.</creatorcontrib><creatorcontrib>Zou, S.</creatorcontrib><title>Maternal alcohol consumption and oral clefts: a meta-analysis</title><title>British journal of oral & maxillofacial surgery</title><addtitle>Br J Oral Maxillofac Surg</addtitle><description>Our aim was to evaluate the possible correlation between maternal alcohol consumption during the first trimester and the risk of having an offspring with non-syndromic oral cleft. We electronically searched all published papers from 1950 to 2019 about maternal alcohol consumption and oral clefts in PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Institute for Scientific Information (ISI) databases. Descriptive and quantitative data were extracted from eligible studies for systemic evaluation and meta-analysis. A total of 12 publications met our inclusion criteria, and nine of them presented sufficient data for quantitative analyses. The overall odds ratio of the nine reports was 1.00 (95% CI 0.87 to 1.15) for cleft lip with or without cleft palate (CL/P) and 1.02 (95% CI 0.92 to 1.14) for cleft palate only, indicating no significant difference between drinking and non-drinking mothers in the risk of having a child with a non-syndromic oral cleft. We found no confirmatory evidence for the presence of a dose-response relation between alcohol consumption and increase in the risk of oral cleft. Nevertheless, four of the studies enrolled found significantly increased risk of CL/P among mothers in the groups that consumed the most alcohol. All but one of the four studies suggested a positive correlation between binge drinking and the occurrence of non-syndromic oral cleft. Although we found no concrete correlation between mild alcohol consumption during pregnancy and the occurrence of non-syndromic oral cleft, precautions should still be taken to avoid binge drinking during the first trimester.</description><subject>alcohol</subject><subject>Alcohol Drinking - adverse effects</subject><subject>binge drinking</subject><subject>birth defect</subject><subject>Case-Control Studies</subject><subject>Cleft Lip - etiology</subject><subject>cleft lip and palate</subject><subject>Cleft Palate - etiology</subject><subject>craniofacial anomalies</subject><subject>Dentistry</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Maternal exposure</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Risk Factors</subject><issn>0266-4356</issn><issn>1532-1940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRbK3-AkFy9JI4sx_5EHqQ4hdUvOh52e5OMCXJ1t1U8N8bbfXoaQ7zvPMyD2PnCBkC5lfrbLX2Xcw4YJVBmQGKAzZFJXiKlYRDNgWe56kUKp-wkxjXAKA4qmM2ESgLARKmbP5kBgq9aRPTWv_m28T6Pm67zdD4PjG9S3wYl7aleojXiUk6GkxqxsBnbOIpO6pNG-lsP2fs9e72ZfGQLp_vHxc3y9QKVQ2pEoVc1VhUyuWIdWWpLBytZF1xKME6VE4UVIJ0dSkdGJQl5CBqriwiiELM2OXu7ib49y3FQXdNtNS2pie_jZrzUvCKV0KNqNihNvgYA9V6E5rOhE-NoL-96bX-8aa_vWko9ehtTF3sC7arjtxf5lfUCMx3AI1vfjQUdLQN9ZZcE8gO2vnm34IvUqB-EQ</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Yin, X.</creator><creator>Li, J.</creator><creator>Li, Y.</creator><creator>Zou, S.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1034-5999</orcidid></search><sort><creationdate>201911</creationdate><title>Maternal alcohol consumption and oral clefts: a meta-analysis</title><author>Yin, X. ; Li, J. ; Li, Y. ; Zou, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-5374bf1795d611f9ce87deb4f92080cd15d37e804df84d0a1480603f25c110373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>alcohol</topic><topic>Alcohol Drinking - adverse effects</topic><topic>binge drinking</topic><topic>birth defect</topic><topic>Case-Control Studies</topic><topic>Cleft Lip - etiology</topic><topic>cleft lip and palate</topic><topic>Cleft Palate - etiology</topic><topic>craniofacial anomalies</topic><topic>Dentistry</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Maternal exposure</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, X.</creatorcontrib><creatorcontrib>Li, J.</creatorcontrib><creatorcontrib>Li, Y.</creatorcontrib><creatorcontrib>Zou, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of oral & maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, X.</au><au>Li, J.</au><au>Li, Y.</au><au>Zou, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal alcohol consumption and oral clefts: a meta-analysis</atitle><jtitle>British journal of oral & maxillofacial surgery</jtitle><addtitle>Br J Oral Maxillofac Surg</addtitle><date>2019-11</date><risdate>2019</risdate><volume>57</volume><issue>9</issue><spage>839</spage><epage>846</epage><pages>839-846</pages><issn>0266-4356</issn><eissn>1532-1940</eissn><abstract>Our aim was to evaluate the possible correlation between maternal alcohol consumption during the first trimester and the risk of having an offspring with non-syndromic oral cleft. We electronically searched all published papers from 1950 to 2019 about maternal alcohol consumption and oral clefts in PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Institute for Scientific Information (ISI) databases. Descriptive and quantitative data were extracted from eligible studies for systemic evaluation and meta-analysis. A total of 12 publications met our inclusion criteria, and nine of them presented sufficient data for quantitative analyses. The overall odds ratio of the nine reports was 1.00 (95% CI 0.87 to 1.15) for cleft lip with or without cleft palate (CL/P) and 1.02 (95% CI 0.92 to 1.14) for cleft palate only, indicating no significant difference between drinking and non-drinking mothers in the risk of having a child with a non-syndromic oral cleft. We found no confirmatory evidence for the presence of a dose-response relation between alcohol consumption and increase in the risk of oral cleft. Nevertheless, four of the studies enrolled found significantly increased risk of CL/P among mothers in the groups that consumed the most alcohol. All but one of the four studies suggested a positive correlation between binge drinking and the occurrence of non-syndromic oral cleft. Although we found no concrete correlation between mild alcohol consumption during pregnancy and the occurrence of non-syndromic oral cleft, precautions should still be taken to avoid binge drinking during the first trimester.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>31473040</pmid><doi>10.1016/j.bjoms.2019.08.013</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1034-5999</orcidid></addata></record> |
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subjects | alcohol Alcohol Drinking - adverse effects binge drinking birth defect Case-Control Studies Cleft Lip - etiology cleft lip and palate Cleft Palate - etiology craniofacial anomalies Dentistry Female Humans Infant, Newborn Maternal exposure Pregnancy Pregnancy Trimester, First Prenatal Exposure Delayed Effects Risk Factors |
title | Maternal alcohol consumption and oral clefts: a meta-analysis |
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