Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments

•Three FGs were isolated from three species of sea cucumbers.•The structures of A1-A4, H1-H4 and S1-S4 from depolymerized FGs were determined.•Three FGs were deduced as -{→4)-[L-FucS-α(1→3)]-D-GlcA-β(1→3)-D- GalNAc4S6S-β(1}n-.•The effects of fucose types on anti-intrinsic tenase activity were discus...

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Veröffentlicht in:	Carbohydrate polymers 2019-11, Vol.224, p.115146-115146, Article 115146
Hauptverfasser:	Cai, Ying, Yang, Wenjiao, Li, Xiaomei, Zhou, Lutan, Wang, Zhongjuan, Lin, Lisha, Chen, Dingyuan, Zhao, Longyan, Li, Zhongkun, Liu, Shubai, Yin, Ronghua, Zuo, Zhili, Gao, Na, Zhao, Jinhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - chemistry Anticoagulants - pharmacology Carbohydrate Sequence Chemical structure Cysteine Endopeptidases Cysteine Proteinase Inhibitors - chemistry Cysteine Proteinase Inhibitors - pharmacology Fucose - chemistry Fucosylated glycosaminoglycan Glycosaminoglycans - chemistry Glycosaminoglycans - pharmacology iXase Neoplasm Proteins - antagonists & inhibitors Oligosaccharide
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