Recent advances in the analysis of polysialic acid from complex biological systems
[Display omitted] •Polysialic acid is of significant interest due its roles in biology and disease.•First systematic review of approaches for extraction and characterisation of polysialic acids from biological matrices.•Approaches to analysis of the degree of polymerisation of polysialic acid evalua...
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Veröffentlicht in: | Carbohydrate polymers 2019-11, Vol.224, p.115145-115145, Article 115145 |
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container_title | Carbohydrate polymers |
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creator | Guo, Xiaoxiao Elkashef, Sara M. Loadman, Paul M. Patterson, Laurence H. Falconer, Robert A. |
description | [Display omitted]
•Polysialic acid is of significant interest due its roles in biology and disease.•First systematic review of approaches for extraction and characterisation of polysialic acids from biological matrices.•Approaches to analysis of the degree of polymerisation of polysialic acid evaluated.•Quantitation considered, including accuracy and limit of detection.
Polysialic acid (polySia) is a unique, well-characterised carbohydrate polymer highly-expressed on the cell surface of neurons in the early stages of mammalian brain development. Post-embryogenesis, it is also re-expressed in a number of tumours of neuroendocrine origin. It plays important roles in modulating cell-cell, and cell-matrix adhesion and migration, tumour invasion and metastasis. Techniques for structural and quantitative characterisation of polySia from tumours and cancer cells are thus essential in exploring the relationship between polySia expression levels and structural and functional changes associated with cancer progression and metastasis. A variety of techniques have been developed to structurally and quantitatively analyse polySia in clinical tissues and other biological samples. In this review, analytical approaches used for the determination of polySia in biological matrices in the past 20 years are discussed, with a particular focus on chemical approaches, and quantitative analysis. |
doi_str_mv | 10.1016/j.carbpol.2019.115145 |
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•Polysialic acid is of significant interest due its roles in biology and disease.•First systematic review of approaches for extraction and characterisation of polysialic acids from biological matrices.•Approaches to analysis of the degree of polymerisation of polysialic acid evaluated.•Quantitation considered, including accuracy and limit of detection.
Polysialic acid (polySia) is a unique, well-characterised carbohydrate polymer highly-expressed on the cell surface of neurons in the early stages of mammalian brain development. Post-embryogenesis, it is also re-expressed in a number of tumours of neuroendocrine origin. It plays important roles in modulating cell-cell, and cell-matrix adhesion and migration, tumour invasion and metastasis. Techniques for structural and quantitative characterisation of polySia from tumours and cancer cells are thus essential in exploring the relationship between polySia expression levels and structural and functional changes associated with cancer progression and metastasis. A variety of techniques have been developed to structurally and quantitatively analyse polySia in clinical tissues and other biological samples. In this review, analytical approaches used for the determination of polySia in biological matrices in the past 20 years are discussed, with a particular focus on chemical approaches, and quantitative analysis.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2019.115145</identifier><identifier>PMID: 31472857</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Clinical Chemistry Tests - methods ; Glycan analysis ; Glycan quantitation ; Humans ; Polysialic acid ; Sialic Acids - analysis ; Sialic Acids - chemistry ; Sialic Acids - isolation & purification</subject><ispartof>Carbohydrate polymers, 2019-11, Vol.224, p.115145-115145, Article 115145</ispartof><rights>2019</rights><rights>Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-d4e0dd9a0ab52a1a6eb3ef69f3907249b6ec4335e4a2dd3aaa0a3dae717fd3413</citedby><cites>FETCH-LOGICAL-c449t-d4e0dd9a0ab52a1a6eb3ef69f3907249b6ec4335e4a2dd3aaa0a3dae717fd3413</cites><orcidid>0000-0002-6426-4430</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2019.115145$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31472857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Xiaoxiao</creatorcontrib><creatorcontrib>Elkashef, Sara M.</creatorcontrib><creatorcontrib>Loadman, Paul M.</creatorcontrib><creatorcontrib>Patterson, Laurence H.</creatorcontrib><creatorcontrib>Falconer, Robert A.</creatorcontrib><title>Recent advances in the analysis of polysialic acid from complex biological systems</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>[Display omitted]
•Polysialic acid is of significant interest due its roles in biology and disease.•First systematic review of approaches for extraction and characterisation of polysialic acids from biological matrices.•Approaches to analysis of the degree of polymerisation of polysialic acid evaluated.•Quantitation considered, including accuracy and limit of detection.
Polysialic acid (polySia) is a unique, well-characterised carbohydrate polymer highly-expressed on the cell surface of neurons in the early stages of mammalian brain development. Post-embryogenesis, it is also re-expressed in a number of tumours of neuroendocrine origin. It plays important roles in modulating cell-cell, and cell-matrix adhesion and migration, tumour invasion and metastasis. Techniques for structural and quantitative characterisation of polySia from tumours and cancer cells are thus essential in exploring the relationship between polySia expression levels and structural and functional changes associated with cancer progression and metastasis. A variety of techniques have been developed to structurally and quantitatively analyse polySia in clinical tissues and other biological samples. In this review, analytical approaches used for the determination of polySia in biological matrices in the past 20 years are discussed, with a particular focus on chemical approaches, and quantitative analysis.</description><subject>Animals</subject><subject>Clinical Chemistry Tests - methods</subject><subject>Glycan analysis</subject><subject>Glycan quantitation</subject><subject>Humans</subject><subject>Polysialic acid</subject><subject>Sialic Acids - analysis</subject><subject>Sialic Acids - chemistry</subject><subject>Sialic Acids - isolation & purification</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v2zAMhoWiRZO1_QkrdNzFmWjJdnQahqL7AAoMKNqzQEt0p0C2UskJln8_Fcl2LS_k4SFf8GHsI4gVCGg_b1YWU7-NYVUL0CuABlRzxpaw7nQFUqlzthSgVLVuoVuwDzlvRKkWxCVbSFBdvW66JXt8JEvTzNHtcbKUuZ_4_Js4ThgO2WceB15CyojBW47WOz6kOHIbx22gP7z3McQXbzHwfMgzjfmaXQwYMt2c-hV7_nb_dPejevj1_efd14fKKqXnyikSzmkU2Dc1ArbUSxpaPUgtulrpviWrpGxIYe2cRCykdEgddIOTCuQV-3S8u03xdUd5NqPPlkLAieIum7pey1qDFm1BmyNqU8w50WC2yY-YDgaEedNpNuak07zpNEedZe_2FLHrR3L_t_75K8CXI0Dl0b2nZLL1VEQ6n8jOxkX_TsRfgdWKKQ</recordid><startdate>20191115</startdate><enddate>20191115</enddate><creator>Guo, Xiaoxiao</creator><creator>Elkashef, Sara M.</creator><creator>Loadman, Paul M.</creator><creator>Patterson, Laurence H.</creator><creator>Falconer, Robert A.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6426-4430</orcidid></search><sort><creationdate>20191115</creationdate><title>Recent advances in the analysis of polysialic acid from complex biological systems</title><author>Guo, Xiaoxiao ; Elkashef, Sara M. ; Loadman, Paul M. ; Patterson, Laurence H. ; Falconer, Robert A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-d4e0dd9a0ab52a1a6eb3ef69f3907249b6ec4335e4a2dd3aaa0a3dae717fd3413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Clinical Chemistry Tests - methods</topic><topic>Glycan analysis</topic><topic>Glycan quantitation</topic><topic>Humans</topic><topic>Polysialic acid</topic><topic>Sialic Acids - analysis</topic><topic>Sialic Acids - chemistry</topic><topic>Sialic Acids - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Xiaoxiao</creatorcontrib><creatorcontrib>Elkashef, Sara M.</creatorcontrib><creatorcontrib>Loadman, Paul M.</creatorcontrib><creatorcontrib>Patterson, Laurence H.</creatorcontrib><creatorcontrib>Falconer, Robert A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Xiaoxiao</au><au>Elkashef, Sara M.</au><au>Loadman, Paul M.</au><au>Patterson, Laurence H.</au><au>Falconer, Robert A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent advances in the analysis of polysialic acid from complex biological systems</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2019-11-15</date><risdate>2019</risdate><volume>224</volume><spage>115145</spage><epage>115145</epage><pages>115145-115145</pages><artnum>115145</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>[Display omitted]
•Polysialic acid is of significant interest due its roles in biology and disease.•First systematic review of approaches for extraction and characterisation of polysialic acids from biological matrices.•Approaches to analysis of the degree of polymerisation of polysialic acid evaluated.•Quantitation considered, including accuracy and limit of detection.
Polysialic acid (polySia) is a unique, well-characterised carbohydrate polymer highly-expressed on the cell surface of neurons in the early stages of mammalian brain development. Post-embryogenesis, it is also re-expressed in a number of tumours of neuroendocrine origin. It plays important roles in modulating cell-cell, and cell-matrix adhesion and migration, tumour invasion and metastasis. Techniques for structural and quantitative characterisation of polySia from tumours and cancer cells are thus essential in exploring the relationship between polySia expression levels and structural and functional changes associated with cancer progression and metastasis. A variety of techniques have been developed to structurally and quantitatively analyse polySia in clinical tissues and other biological samples. In this review, analytical approaches used for the determination of polySia in biological matrices in the past 20 years are discussed, with a particular focus on chemical approaches, and quantitative analysis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31472857</pmid><doi>10.1016/j.carbpol.2019.115145</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6426-4430</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Animals Clinical Chemistry Tests - methods Glycan analysis Glycan quantitation Humans Polysialic acid Sialic Acids - analysis Sialic Acids - chemistry Sialic Acids - isolation & purification |
title | Recent advances in the analysis of polysialic acid from complex biological systems |
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