hnRNPU/TrkB Defines a Chromatin Accessibility Checkpoint for Liver Injury and Nonalcoholic Steatohepatitis Pathogenesis

Background and Aims Nonalcoholic steatohepatitis (NASH) is a progressive liver disease that is characterized by liver injury, inflammation, and fibrosis. NASH pathogenesis is linked to reprogramming of chromatin landscape in the liver that predisposes hepatocytes to stress‐induced tissue injury. How...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2020-04, Vol.71 (4), p.1228-1246
Hauptverfasser:	Xiong, Jing, Liu, Tongyu, Mi, Lin, Kuang, Henry, Xiong, Xuelian, Chen, Zhimin, Li, Siming, Lin, Jiandie D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain-Derived Neurotrophic Factor - therapeutic use Cell death Chromatin Chromatin Assembly and Disassembly Diet Disease Models, Animal Fibrosis Gene expression Hepatocytes Hepatocytes - metabolism Hepatology Heterogeneous-Nuclear Ribonucleoprotein U - genetics Heterogeneous-Nuclear Ribonucleoprotein U - metabolism Immunoprecipitation Inflammation Liver Liver diseases Matrix protein Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane proteins Mice Mice, Transgenic Neurotrophic factors Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - therapy Pathogenesis Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Ribonucleic acid RNA Transcriptome TrkB receptors
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