BRCA1 promoter methylation in peripheral blood is associated with the risk of triple‐negative breast cancer

Methylation of the promoter of the BRCA1 gene in DNA derived from peripheral blood cells is a possible risk factor for breast cancer. It is not clear if this association is restricted to certain types of breast cancer or is a general phenomenon. We evaluated BRCA1 methylation status in peripheral bl...

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Veröffentlicht in:	International journal of cancer 2020-03, Vol.146 (5), p.1293-1298
Hauptverfasser:	Prajzendanc, Karolina, Domagała, Paweł, Hybiak, Jolanta, Ryś, Janusz, Huzarski, Tomasz, Szwiec, Marek, Tomiczek‐Szwiec, Joanna, Redelbach, Wojciech, Sejda, Aleksandra, Gronwald, Jacek, Kluz, Tomasz, Wiśniowski, Rafał, Cybulski, Cezary, Łukomska, Alicja, Białkowska, Katarzyna, Sukiennicki, Grzegorz, Kulczycka, Katarzyna, Narod, Steven A., Wojdacz, Tomasz K., Lubiński, Jan, Jakubowska, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Blood Blood cells Brain cancer BRCA1 gene BRCA1 protein BRCA1 Protein - genetics Breast - pathology Breast cancer Cancer Case-Control Studies Deoxyribonucleic acid DNA DNA Methylation Female Follow-Up Studies Genetic Predisposition to Disease Health risks Humans Medical research methylation in peripheral blood Middle Aged Paraffin Peripheral blood Promoter Regions, Genetic - genetics Risk factors TNBC Triple Negative Breast Neoplasms - blood Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology Tumors
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