Comparative analysis of human leucocyte antigen between idiopathic and anti‐PD‐1 antibody induced isolated adrenocorticotropic hormone deficiency: A pilot study

Background Adult‐onset idiopathic isolated adrenocorticotropic hormone deficiency (id‐IAD) is a rare disease with unknown aetiology. Recently, numerous cases of anti‐PD‐1 antibody‐induced IAD (PD1‐IAD) have been reported, but the clinical course, predictive factors and relationship to id‐IAD have no...

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Veröffentlicht in:	Clinical endocrinology (Oxford) 2019-12, Vol.91 (6), p.786-792
Hauptverfasser:	Inaba, Hidefumi, Ariyasu, Hiroyuki, Iwakura, Hiroshi, Ueda, Yoko, Kurimoto, Chiaki, Uraki, Shinsuke, Takeshima, Ken, Yamaoka, Hiroyuki, Furukawa, Yasushi, Morita, Shuhei, Nishi, Masahiro, Akamizu, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic hormone Alleles Antigens antiprogrammed cell death protein 1 antibody Cell death Comparative analysis Drb1 protein Gene frequency Haplotypes Histocompatibility antigen HLA human leucocyte antigen Hypoglycemia Hyponatremia immune‐checkpoint inhibitor PD-1 protein pituitary gland Rare diseases Tissue typing
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