Evaluation of Chemically-Cleavable Linkers for Quantitative Mapping of Small Molecule-Cysteinome Reactivity

Numerous reagents have been developed to enable chemical proteomic analysis of small molecule-protein interactomes. However, the performance of these reagents has not been systematically evaluated and compared. Herein, we report our efforts to conduct a parallel assessment of two widely used chemica...

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Veröffentlicht in:	ACS chemical biology 2019-09, Vol.14 (9), p.1940-1950
Hauptverfasser:	Rabalski, Adam J, Bogdan, Andrew R, Baranczak, Aleksandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Azo Compounds - chemistry Biotin - analogs & derivatives Cell Line, Tumor Cysteine - analysis Cysteine - chemistry Humans Protein Binding Proteome - chemistry Proteome - metabolism Proteomics - methods Quinazolinones - metabolism Quinazolinones - pharmacology Silanes - chemistry
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