Carboxylic acid reductases (CARs): An industrial perspective

•Carboxylic acid reductases (CARs) chemoselectively reduce carboxylic acids to aldehydes.•CARs are Mg2+, ATP and NADPH dependent and can be applied in vivo or in vitro with cofactor recycling.•CARs have been applied in a variety of biocatalytic cascades to date.•CARs are promising industrial biocata...

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Veröffentlicht in:	Journal of biotechnology 2019-10, Vol.304, p.78-88
Hauptverfasser:	Derrington, Sasha R., Turner, Nicholas J., France, Scott P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Aldehydes - metabolism Biocatalysis Biocatalytic cascades Bioreactors - microbiology Carboxylic acid reductases Carboxylic acids Carboxylic Acids - metabolism Odorants Oxidoreductases - genetics Oxidoreductases - metabolism Protein Engineering - methods
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