Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

Caloric restriction and intermittent fasting are known to prolong life- and healthspan in model organisms, while their effects on humans are less well studied. In a randomized controlled trial study (ClinicalTrials.gov identifier: NCT02673515), we show that 4 weeks of strict alternate day fasting (A...

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Veröffentlicht in:	Cell metabolism 2019-09, Vol.30 (3), p.462-476.e6
Hauptverfasser:	Stekovic, Slaven, Hofer, Sebastian J., Tripolt, Norbert, Aon, Miguel A., Royer, Philipp, Pein, Lukas, Stadler, Julia T., Pendl, Tobias, Prietl, Barbara, Url, Jasmin, Schroeder, Sabrina, Tadic, Jelena, Eisenberg, Tobias, Magnes, Christoph, Stumpe, Michael, Zuegner, Elmar, Bordag, Natalie, Riedl, Regina, Schmidt, Albrecht, Kolesnik, Ewald, Verheyen, Nicolas, Springer, Anna, Madl, Tobias, Sinner, Frank, de Cabo, Rafael, Kroemer, Guido, Obermayer-Pietsch, Barbara, Dengjel, Jörn, Sourij, Harald, Pieber, Thomas R., Madeo, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyric Acid - blood Adult aging Aging - blood Biomarkers - blood Body Mass Index body shape caloric restriction Caloric Restriction - adverse effects cardiovascular disease risk clinical trial Energy Intake - physiology fasting Fasting - adverse effects Fasting - blood fat distribution Fatty Acids, Unsaturated - blood Female Healthy Aging - blood Healthy Volunteers Humans Intercellular Adhesion Molecule-1 - blood intermittent fasting Lipoproteins, LDL - blood Male Middle Aged Pilot Projects Prospective Studies RCT triiodothyronine Triiodothyronine - blood Weight Loss
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