Critical role of OX40/OX40L in ILC2-mediated activation of CD4+T cells during respiratory syncytial virus infection in mice

CD4+T cells are crucial cellular source of type 2 cytokines and responsible for RSV-induced asthma-like symptoms and asthma exacerbations. However, the mechanism for regulating the activation of CD4+T cells during RSV infection is not clear completely. We show in this study that infection with RSV m...

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Veröffentlicht in:	International immunopharmacology 2019-11, Vol.76, p.105784-105784, Article 105784
Hauptverfasser:	Wu, Jianqi, Cui, Yulin, Zhu, Wenwen, Bai, Song, Zhao, Na, Liu, Beixing
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adoptive transfer Animals Antibodies Asthma CD4 antigen CD4+T cells Cell activation Cell culture Coculture Techniques Cytokines Cytokines - immunology Expansion Female ILC2s Immunity, Innate Infections Lung - cytology Lung - immunology Lungs Lymphocytes Lymphocytes - immunology Lymphocytes T Lymphoid cells Mice, Inbred BALB C mRNA OX40 Ligand - immunology OX40/OX40L Ox40L protein Receptors, OX40 - immunology Respiratory syncytial virus Respiratory syncytial virus (RSV) Respiratory Syncytial Virus Infections - immunology Spleen - cytology Viruses
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