Interleukin 1 beta and Matrix Metallopeptidase 3 Contribute to Development of Epidermal Growth Factor Receptor–Dependent Serrated Polyps in Mouse Cecum

Transgenic mice (HBUS) that express the epidermal growth factor receptor (EGFR) ligand HBEGF (heparin-binding epidermal growth factor–like growth factor) and a constitutively active G protein–coupled receptor (US28) in intestinal epithelial cells develop serrated polyps in the cecum. Development of...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2019-12, Vol.157 (6), p.1572-1583.e8
Hauptverfasser:	He, Zhengxiang, Chen, Lili, Chen, Grace, Smaldini, Paola, Bongers, Gerold, Catalan-Dibene, Jovani, Furtado, Glaucia C., Lira, Sergio A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - immunology Barrier Breakdown Cecum - cytology Cecum - immunology Cecum - pathology Colonic Polyps - immunology Cytokine Diphtheria Toxin - administration & dosage Diphtheria Toxin - immunology Disease Models, Animal Epithelial Cells - immunology Epithelial Cells - pathology ErbB Receptors - antagonists & inhibitors ErbB Receptors - metabolism Fibroblasts - immunology Fibroblasts - metabolism Gefitinib - pharmacology Heparin-binding EGF-like Growth Factor - genetics Heparin-binding EGF-like Growth Factor - metabolism Humans Hydroxamic Acids - pharmacology Interleukin-1beta - immunology Interleukin-1beta - metabolism Intestinal Mucosa - cytology Intestinal Mucosa - immunology Intestinal Mucosa - pathology Matrix Metalloproteinase 3 - immunology Matrix Metalloproteinase 3 - metabolism Matrix Metalloproteinase Inhibitors - pharmacology Mice Mice, Transgenic Neoplasm Receptor, Platelet-Derived Growth Factor alpha - metabolism Stroma Sulfonamides - pharmacology
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