Correlations between the Peptide Hormone Ghrelin and Proinflammatory Cytokines in Experimental Periodontitis Models of Female Rats at Different Stages of the Life Cycle
•Ghrelin is thought to be part of host defence and the immune response.•Ghrelin release differs according to gender, developmental stage and sex hormones.•Postmenopause ghrelin levels may be correlated with inflammatory cytokine levels.•Plasma ghrelin levels in the postmenopausal group may be associ...
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| Veröffentlicht in: | Archives of oral biology 2019-12, Vol.108, p.104518-104518, Article 104518 |
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| container_title | Archives of oral biology |
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| creator | Ereş, Gülden Su Akgün Demirtaş, Ceren Toptaş, Ece Yılmaz, Ayça Dilara Sengüven, Burcu Kamburoğlu, Kıvanç |
| description | •Ghrelin is thought to be part of host defence and the immune response.•Ghrelin release differs according to gender, developmental stage and sex hormones.•Postmenopause ghrelin levels may be correlated with inflammatory cytokine levels.•Plasma ghrelin levels in the postmenopausal group may be associated with IL-1
The aim of this study was to examine the correlations between the levels of ghrelin and inflammatory and bone metabolism markers in rats with periodontitis.
Thirty female Wistar rats (6 trial rats and 4 control rats in each group) were divided into pubertal, adult and postmenopausal groups. Periodontitis was induced by ligatures. On the 21 st day, blood was collected and all rats were then sacrificed. The levels of osteocalcin, osteoprotegerin, alkaline phosphatase, tumour necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), acylated ghrelin, total ghrelin and soluble receptor activator of nuclear factor-kB ligands in the blood samples were measured using enzyme-linked immunosorbent assays. The jaws were decalcified in a Tris-EDTA solution and embedded in paraffin and 4-5 μm sections were cut for IL-β, TNF -α and ghrelin staining.
Significantly higher serum alkaline phosphatase levels were detected in the trial rats in the pubertal group than in the control rats (p = 0.033). In the postmenopausal group, ghrelin levels positively correlated with interleukin 1 beta levels (r = 0.708, p |
| doi_str_mv | 10.1016/j.archoralbio.2019.104518 |
| format | Article |
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The aim of this study was to examine the correlations between the levels of ghrelin and inflammatory and bone metabolism markers in rats with periodontitis.
Thirty female Wistar rats (6 trial rats and 4 control rats in each group) were divided into pubertal, adult and postmenopausal groups. Periodontitis was induced by ligatures. On the 21 st day, blood was collected and all rats were then sacrificed. The levels of osteocalcin, osteoprotegerin, alkaline phosphatase, tumour necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), acylated ghrelin, total ghrelin and soluble receptor activator of nuclear factor-kB ligands in the blood samples were measured using enzyme-linked immunosorbent assays. The jaws were decalcified in a Tris-EDTA solution and embedded in paraffin and 4-5 μm sections were cut for IL-β, TNF -α and ghrelin staining.
Significantly higher serum alkaline phosphatase levels were detected in the trial rats in the pubertal group than in the control rats (p = 0.033). In the postmenopausal group, ghrelin levels positively correlated with interleukin 1 beta levels (r = 0.708, p < 0.05). Among all trial rats, the postmenopausal group exhibited significantly higher levels of acylated ghrelin than the other groups (p = 0.001). Significantly higher osteoprotegerin levels were observed in the control rats than in the trial rats in the postmenopausal group (p = 0.012). Inflammation scores were significantly higher in adult trial rats than in controls (p = 0.024); significantly higher TNF-α levels were detected in postmenopausal experimental rats than in the adult experimental group (p = 0.025).
We concluded that total ghrelin levels in serum only correlated with IL-β levels in postmenopausal rats.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2019.104518</identifier><identifier>PMID: 31472279</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Cytokines - blood ; Cytokines - metabolism ; Dentistry ; Female ; ghrelin ; Ghrelin - blood ; Ghrelin - metabolism ; IL-1β ; Interleukin-1beta - metabolism ; Menopause - physiology ; periodontitis ; Periodontitis - metabolism ; postmenopause ; puberty ; Rats ; Rats, Wistar ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Archives of oral biology, 2019-12, Vol.108, p.104518-104518, Article 104518</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-4c52bb36329481715b225ee28216e859ba11585059b0d358ec27b656515042103</citedby><cites>FETCH-LOGICAL-c377t-4c52bb36329481715b225ee28216e859ba11585059b0d358ec27b656515042103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.archoralbio.2019.104518$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31472279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ereş, Gülden</creatorcontrib><creatorcontrib>Su Akgün Demirtaş, Ceren</creatorcontrib><creatorcontrib>Toptaş, Ece</creatorcontrib><creatorcontrib>Yılmaz, Ayça Dilara</creatorcontrib><creatorcontrib>Sengüven, Burcu</creatorcontrib><creatorcontrib>Kamburoğlu, Kıvanç</creatorcontrib><title>Correlations between the Peptide Hormone Ghrelin and Proinflammatory Cytokines in Experimental Periodontitis Models of Female Rats at Different Stages of the Life Cycle</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>•Ghrelin is thought to be part of host defence and the immune response.•Ghrelin release differs according to gender, developmental stage and sex hormones.•Postmenopause ghrelin levels may be correlated with inflammatory cytokine levels.•Plasma ghrelin levels in the postmenopausal group may be associated with IL-1
The aim of this study was to examine the correlations between the levels of ghrelin and inflammatory and bone metabolism markers in rats with periodontitis.
Thirty female Wistar rats (6 trial rats and 4 control rats in each group) were divided into pubertal, adult and postmenopausal groups. Periodontitis was induced by ligatures. On the 21 st day, blood was collected and all rats were then sacrificed. The levels of osteocalcin, osteoprotegerin, alkaline phosphatase, tumour necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), acylated ghrelin, total ghrelin and soluble receptor activator of nuclear factor-kB ligands in the blood samples were measured using enzyme-linked immunosorbent assays. The jaws were decalcified in a Tris-EDTA solution and embedded in paraffin and 4-5 μm sections were cut for IL-β, TNF -α and ghrelin staining.
Significantly higher serum alkaline phosphatase levels were detected in the trial rats in the pubertal group than in the control rats (p = 0.033). In the postmenopausal group, ghrelin levels positively correlated with interleukin 1 beta levels (r = 0.708, p < 0.05). Among all trial rats, the postmenopausal group exhibited significantly higher levels of acylated ghrelin than the other groups (p = 0.001). Significantly higher osteoprotegerin levels were observed in the control rats than in the trial rats in the postmenopausal group (p = 0.012). Inflammation scores were significantly higher in adult trial rats than in controls (p = 0.024); significantly higher TNF-α levels were detected in postmenopausal experimental rats than in the adult experimental group (p = 0.025).
We concluded that total ghrelin levels in serum only correlated with IL-β levels in postmenopausal rats.</description><subject>Animals</subject><subject>Cytokines - blood</subject><subject>Cytokines - metabolism</subject><subject>Dentistry</subject><subject>Female</subject><subject>ghrelin</subject><subject>Ghrelin - blood</subject><subject>Ghrelin - metabolism</subject><subject>IL-1β</subject><subject>Interleukin-1beta - metabolism</subject><subject>Menopause - physiology</subject><subject>periodontitis</subject><subject>Periodontitis - metabolism</subject><subject>postmenopause</subject><subject>puberty</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1yFCEUhSnLlJlEX8HCnZsegW7oZmm1-bFqrKT8WVM0fdthpGEEJsm8UR5TxomWS1dcqO-cy70HoTeULCmh4t1mqaNZh6jdYMOSESrLe8Np9wwtaNfKinIinqMFIaSupBTyFJ2ltClXLgR9gU5r2rSMtXKBHvsQIzidbfAJD5DvATzOa8C3sM12BHwd4hw84Kt14azH2o_4NgbrJ6fnWecQ97jf5_DDeki4ABcPW4h2Bp-1Ky7RhjH4bLNN-FMYwSUcJnwJs3aAP-ucsM74g50miEWCv2T9HX4jh0-s7ATF3Th4iU4m7RK8ejrP0bfLi6_9dbW6ufrYv19Vpm7bXDWGs2GoRc1k09GW8oExDsA6RgV0XA6aUt5xUioy1rwDw9pBcMHLyhpGSX2O3h59tzH83EHKarbJgHPaQ9glxVhXU8IZowWVR9TEkFKESW3L3DruFSXqEJTaqH-CUoeg1DGoon391GY3zDD-Vf5JpgD9ESgLgzsLUSVjwRsYbQST1Rjsf7T5BbLdq7E</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Ereş, Gülden</creator><creator>Su Akgün Demirtaş, Ceren</creator><creator>Toptaş, Ece</creator><creator>Yılmaz, Ayça Dilara</creator><creator>Sengüven, Burcu</creator><creator>Kamburoğlu, Kıvanç</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201912</creationdate><title>Correlations between the Peptide Hormone Ghrelin and Proinflammatory Cytokines in Experimental Periodontitis Models of Female Rats at Different Stages of the Life Cycle</title><author>Ereş, Gülden ; Su Akgün Demirtaş, Ceren ; Toptaş, Ece ; Yılmaz, Ayça Dilara ; Sengüven, Burcu ; Kamburoğlu, Kıvanç</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-4c52bb36329481715b225ee28216e859ba11585059b0d358ec27b656515042103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Cytokines - blood</topic><topic>Cytokines - metabolism</topic><topic>Dentistry</topic><topic>Female</topic><topic>ghrelin</topic><topic>Ghrelin - blood</topic><topic>Ghrelin - metabolism</topic><topic>IL-1β</topic><topic>Interleukin-1beta - metabolism</topic><topic>Menopause - physiology</topic><topic>periodontitis</topic><topic>Periodontitis - metabolism</topic><topic>postmenopause</topic><topic>puberty</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ereş, Gülden</creatorcontrib><creatorcontrib>Su Akgün Demirtaş, Ceren</creatorcontrib><creatorcontrib>Toptaş, Ece</creatorcontrib><creatorcontrib>Yılmaz, Ayça Dilara</creatorcontrib><creatorcontrib>Sengüven, Burcu</creatorcontrib><creatorcontrib>Kamburoğlu, Kıvanç</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ereş, Gülden</au><au>Su Akgün Demirtaş, Ceren</au><au>Toptaş, Ece</au><au>Yılmaz, Ayça Dilara</au><au>Sengüven, Burcu</au><au>Kamburoğlu, Kıvanç</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlations between the Peptide Hormone Ghrelin and Proinflammatory Cytokines in Experimental Periodontitis Models of Female Rats at Different Stages of the Life Cycle</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2019-12</date><risdate>2019</risdate><volume>108</volume><spage>104518</spage><epage>104518</epage><pages>104518-104518</pages><artnum>104518</artnum><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>•Ghrelin is thought to be part of host defence and the immune response.•Ghrelin release differs according to gender, developmental stage and sex hormones.•Postmenopause ghrelin levels may be correlated with inflammatory cytokine levels.•Plasma ghrelin levels in the postmenopausal group may be associated with IL-1
The aim of this study was to examine the correlations between the levels of ghrelin and inflammatory and bone metabolism markers in rats with periodontitis.
Thirty female Wistar rats (6 trial rats and 4 control rats in each group) were divided into pubertal, adult and postmenopausal groups. Periodontitis was induced by ligatures. On the 21 st day, blood was collected and all rats were then sacrificed. The levels of osteocalcin, osteoprotegerin, alkaline phosphatase, tumour necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), acylated ghrelin, total ghrelin and soluble receptor activator of nuclear factor-kB ligands in the blood samples were measured using enzyme-linked immunosorbent assays. The jaws were decalcified in a Tris-EDTA solution and embedded in paraffin and 4-5 μm sections were cut for IL-β, TNF -α and ghrelin staining.
Significantly higher serum alkaline phosphatase levels were detected in the trial rats in the pubertal group than in the control rats (p = 0.033). In the postmenopausal group, ghrelin levels positively correlated with interleukin 1 beta levels (r = 0.708, p < 0.05). Among all trial rats, the postmenopausal group exhibited significantly higher levels of acylated ghrelin than the other groups (p = 0.001). Significantly higher osteoprotegerin levels were observed in the control rats than in the trial rats in the postmenopausal group (p = 0.012). Inflammation scores were significantly higher in adult trial rats than in controls (p = 0.024); significantly higher TNF-α levels were detected in postmenopausal experimental rats than in the adult experimental group (p = 0.025).
We concluded that total ghrelin levels in serum only correlated with IL-β levels in postmenopausal rats.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31472279</pmid><doi>10.1016/j.archoralbio.2019.104518</doi><tpages>1</tpages></addata></record> |
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| ispartof | Archives of oral biology, 2019-12, Vol.108, p.104518-104518, Article 104518 |
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| subjects | Animals Cytokines - blood Cytokines - metabolism Dentistry Female ghrelin Ghrelin - blood Ghrelin - metabolism IL-1β Interleukin-1beta - metabolism Menopause - physiology periodontitis Periodontitis - metabolism postmenopause puberty Rats Rats, Wistar Tumor Necrosis Factor-alpha - metabolism |
| title | Correlations between the Peptide Hormone Ghrelin and Proinflammatory Cytokines in Experimental Periodontitis Models of Female Rats at Different Stages of the Life Cycle |
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