Epigallocatechin gallate (EGCG) suppresses growth and tumorigenicity in breast cancer cells by downregulation of miR-25

The aim of the present study was to investigate the anticancer effects and potential mechanisms of polyphenol epigallocatechin-3-gallate (EGCG) on breast cancer MCF-7 cells in vitro and in vivo. Our results showed that EGCG significantly inhibited MCF-7 cell viability in a time- and dose-dependent m...

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Veröffentlicht in:	Bioengineered 2019-01, Vol.10 (1), p.374-382
Hauptverfasser:	Zan, Lingling, Chen, Qingfeng, Zhang, Lei, Li, Xiaona
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - pharmacology apoptosis Apoptosis - drug effects Apoptosis - genetics breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Caspase 3 - genetics Caspase 3 - metabolism Caspase 9 - genetics Caspase 9 - metabolism Catechin - analogs & derivatives Catechin - pharmacology Cell Proliferation - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug Female G2 Phase Cell Cycle Checkpoints - drug effects G2 Phase Cell Cycle Checkpoints - genetics Gene Expression Regulation, Neoplastic Humans Ki-67 Antigen - genetics Ki-67 Antigen - metabolism MCF-7 Cells Mice Mice, SCID MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Polyphenol epigallocatechin-3-gallate proliferation Research Paper Signal Transduction Tumor Burden - drug effects Xenograft Model Antitumor Assays
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