Incidence of gastro‐intestinal anomalies and surgical outcome of fetuses diagnosed with echogenic bowel and bowel dilatation
Background We aimed to evaluate the incidence of gastro‐intestinal (GI) anomalies and surgical outcome in fetuses diagnosed with either echogenic bowel (EB) or EB plus bowel dilatation (BD) but no associated chromosomal, DNA and/or additional structural defects. Methods A 10‐year (2008‐2018) retrosp...
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| Veröffentlicht in: | Prenatal diagnosis 2019-11, Vol.39 (12), p.1115-1119 |
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| creator | Laird, Ashleigh Shekleton, Paul Nataraja, Ramesh M. Kimber, Christopher Pacilli, Maurizio |
| description | Background
We aimed to evaluate the incidence of gastro‐intestinal (GI) anomalies and surgical outcome in fetuses diagnosed with either echogenic bowel (EB) or EB plus bowel dilatation (BD) but no associated chromosomal, DNA and/or additional structural defects.
Methods
A 10‐year (2008‐2018) retrospective review was performed on all fetuses diagnosed with EB and EB+BD (RES‐18‐0000‐072Q). Results are reported as number of cases (%) and mean ±SD. Fisher's exact test, Mann‐Whitney U test and logistic regression were used to identify differences between groups and predisposing factors for gastro‐intestinal anomalies.
Results
We identified 41 fetuses with EB and 14 fetuses with EB+BD. Post‐natal surgical intervention was required in no patient of the EB group and in 7/14 (50%) of the EB+BD group, p |
| doi_str_mv | 10.1002/pd.5552 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2282467522</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2282467522</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3452-c5d06271a581e2be1b626e86f48a283c3118f9a5477465dc42d0d52a7dc220223</originalsourceid><addsrcrecordid>eNp1kc1KAzEUhYMotlbxDWTAhYK05meSmVlK_SsUdKHrIU3utCkzSZ3MULoRH8Fn9ElMf3QhuLqHm-8eyDkInRI8IBjT64UecM7pHuoSnCV9TCnbR11MgmYpJx105P08gCnNkkPUYSQWJMmyLnofWWU0WAWRK6Kp9E3tvj4-jW3AN8bKMpLWVbI04IPSkW_rqVFh7dpGuWpzVUDT-vCujZxa50FHS9PMIlAzNwVrVDRxSyg351ulTSkb2Rhnj9FBIUsPJ7vZQ6_3dy_Dx_746WE0vBn3FYs57SuusaAJkTwlQCdAJoIKSEURp5KmTDFC0iKTPE6SWHCtYqqx5lQmWlG6DqOHLre-i9q9teFreWW8grKUFlzrcxqSiUXCN-j5H3Tu2jokEShGBBOM4zV1saVU7byvocgXtalkvcoJzteV5AudrysJ5NnOr51UoH-5nw4CcLUFlqaE1X8--fPtxu4bz-eVPQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2316363502</pqid></control><display><type>article</type><title>Incidence of gastro‐intestinal anomalies and surgical outcome of fetuses diagnosed with echogenic bowel and bowel dilatation</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Laird, Ashleigh ; Shekleton, Paul ; Nataraja, Ramesh M. ; Kimber, Christopher ; Pacilli, Maurizio</creator><creatorcontrib>Laird, Ashleigh ; Shekleton, Paul ; Nataraja, Ramesh M. ; Kimber, Christopher ; Pacilli, Maurizio</creatorcontrib><description>Background
We aimed to evaluate the incidence of gastro‐intestinal (GI) anomalies and surgical outcome in fetuses diagnosed with either echogenic bowel (EB) or EB plus bowel dilatation (BD) but no associated chromosomal, DNA and/or additional structural defects.
Methods
A 10‐year (2008‐2018) retrospective review was performed on all fetuses diagnosed with EB and EB+BD (RES‐18‐0000‐072Q). Results are reported as number of cases (%) and mean ±SD. Fisher's exact test, Mann‐Whitney U test and logistic regression were used to identify differences between groups and predisposing factors for gastro‐intestinal anomalies.
Results
We identified 41 fetuses with EB and 14 fetuses with EB+BD. Post‐natal surgical intervention was required in no patient of the EB group and in 7/14 (50%) of the EB+BD group, p<0.001. The risk of having a GI anomaly was higher in the EB+BD group (RR 42.0 [2.5‐691.6]; p=0.009). Advanced maternal age (p=0.04), ascites (p=0.006) and polyhydramnios (p=0.007) were associated with a higher incidence of GI pathology.
Conclusions
In fetuses with no associated chromosomal, DNA and/or additional structural defects, the finding of EB+BD is associated with 50% incidence of GI anomalies at birth. Advanced maternal age, ascites and polyhydramnios are also associated with higher incidence of GI pathology at birth.
What is already known on this topic:
Echogenic bowel and bowel dilatation are detected on fetal ultrasonographic examinations during the second and third trimesters.
Echogenic bowel and bowel dilatation can be secondary to underlying pathologies such as meconium ileus and other gastro‐intestinal tract abnormalities.
In fetuses with no associated chromosomal, DNA and/or additional structural defects, the findings of echogenic bowel and bowel dilatation poses a significant dilemma for antenatal counselling and planning of post‐natal management.
What this study adds:
Echogenic bowel in conjunction with bowel dilatation is associated with 50% incidence of gastro‐intestinal anomalies requiring surgical intervention at birth.
The presence of polyhydramnios, ascites and advanced maternal age, are associated with higher incidence of postnatal gastro‐intestinal pathology.
Fetuses diagnosed with echogenic bowel in conjunction with bowel dilatation despite not having associated chromosomal, DNA and/or additional structural defects, should be followed‐up and delivered in a paediatric surgical tertiary centre.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.5552</identifier><identifier>PMID: 31461799</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Anomalies ; Ascites ; Birth ; Defects ; Deoxyribonucleic acid ; DNA ; Fetuses ; Health risk assessment ; Incidence ; Intestine ; Pathology ; Surgical outcomes</subject><ispartof>Prenatal diagnosis, 2019-11, Vol.39 (12), p.1115-1119</ispartof><rights>2019 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3452-c5d06271a581e2be1b626e86f48a283c3118f9a5477465dc42d0d52a7dc220223</citedby><cites>FETCH-LOGICAL-c3452-c5d06271a581e2be1b626e86f48a283c3118f9a5477465dc42d0d52a7dc220223</cites><orcidid>0000-0003-1259-4304</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.5552$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.5552$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31461799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laird, Ashleigh</creatorcontrib><creatorcontrib>Shekleton, Paul</creatorcontrib><creatorcontrib>Nataraja, Ramesh M.</creatorcontrib><creatorcontrib>Kimber, Christopher</creatorcontrib><creatorcontrib>Pacilli, Maurizio</creatorcontrib><title>Incidence of gastro‐intestinal anomalies and surgical outcome of fetuses diagnosed with echogenic bowel and bowel dilatation</title><title>Prenatal diagnosis</title><addtitle>Prenat Diagn</addtitle><description>Background
We aimed to evaluate the incidence of gastro‐intestinal (GI) anomalies and surgical outcome in fetuses diagnosed with either echogenic bowel (EB) or EB plus bowel dilatation (BD) but no associated chromosomal, DNA and/or additional structural defects.
Methods
A 10‐year (2008‐2018) retrospective review was performed on all fetuses diagnosed with EB and EB+BD (RES‐18‐0000‐072Q). Results are reported as number of cases (%) and mean ±SD. Fisher's exact test, Mann‐Whitney U test and logistic regression were used to identify differences between groups and predisposing factors for gastro‐intestinal anomalies.
Results
We identified 41 fetuses with EB and 14 fetuses with EB+BD. Post‐natal surgical intervention was required in no patient of the EB group and in 7/14 (50%) of the EB+BD group, p<0.001. The risk of having a GI anomaly was higher in the EB+BD group (RR 42.0 [2.5‐691.6]; p=0.009). Advanced maternal age (p=0.04), ascites (p=0.006) and polyhydramnios (p=0.007) were associated with a higher incidence of GI pathology.
Conclusions
In fetuses with no associated chromosomal, DNA and/or additional structural defects, the finding of EB+BD is associated with 50% incidence of GI anomalies at birth. Advanced maternal age, ascites and polyhydramnios are also associated with higher incidence of GI pathology at birth.
What is already known on this topic:
Echogenic bowel and bowel dilatation are detected on fetal ultrasonographic examinations during the second and third trimesters.
Echogenic bowel and bowel dilatation can be secondary to underlying pathologies such as meconium ileus and other gastro‐intestinal tract abnormalities.
In fetuses with no associated chromosomal, DNA and/or additional structural defects, the findings of echogenic bowel and bowel dilatation poses a significant dilemma for antenatal counselling and planning of post‐natal management.
What this study adds:
Echogenic bowel in conjunction with bowel dilatation is associated with 50% incidence of gastro‐intestinal anomalies requiring surgical intervention at birth.
The presence of polyhydramnios, ascites and advanced maternal age, are associated with higher incidence of postnatal gastro‐intestinal pathology.
Fetuses diagnosed with echogenic bowel in conjunction with bowel dilatation despite not having associated chromosomal, DNA and/or additional structural defects, should be followed‐up and delivered in a paediatric surgical tertiary centre.</description><subject>Anomalies</subject><subject>Ascites</subject><subject>Birth</subject><subject>Defects</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Fetuses</subject><subject>Health risk assessment</subject><subject>Incidence</subject><subject>Intestine</subject><subject>Pathology</subject><subject>Surgical outcomes</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kc1KAzEUhYMotlbxDWTAhYK05meSmVlK_SsUdKHrIU3utCkzSZ3MULoRH8Fn9ElMf3QhuLqHm-8eyDkInRI8IBjT64UecM7pHuoSnCV9TCnbR11MgmYpJx105P08gCnNkkPUYSQWJMmyLnofWWU0WAWRK6Kp9E3tvj4-jW3AN8bKMpLWVbI04IPSkW_rqVFh7dpGuWpzVUDT-vCujZxa50FHS9PMIlAzNwVrVDRxSyg351ulTSkb2Rhnj9FBIUsPJ7vZQ6_3dy_Dx_746WE0vBn3FYs57SuusaAJkTwlQCdAJoIKSEURp5KmTDFC0iKTPE6SWHCtYqqx5lQmWlG6DqOHLre-i9q9teFreWW8grKUFlzrcxqSiUXCN-j5H3Tu2jokEShGBBOM4zV1saVU7byvocgXtalkvcoJzteV5AudrysJ5NnOr51UoH-5nw4CcLUFlqaE1X8--fPtxu4bz-eVPQ</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Laird, Ashleigh</creator><creator>Shekleton, Paul</creator><creator>Nataraja, Ramesh M.</creator><creator>Kimber, Christopher</creator><creator>Pacilli, Maurizio</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1259-4304</orcidid></search><sort><creationdate>201911</creationdate><title>Incidence of gastro‐intestinal anomalies and surgical outcome of fetuses diagnosed with echogenic bowel and bowel dilatation</title><author>Laird, Ashleigh ; Shekleton, Paul ; Nataraja, Ramesh M. ; Kimber, Christopher ; Pacilli, Maurizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3452-c5d06271a581e2be1b626e86f48a283c3118f9a5477465dc42d0d52a7dc220223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anomalies</topic><topic>Ascites</topic><topic>Birth</topic><topic>Defects</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Fetuses</topic><topic>Health risk assessment</topic><topic>Incidence</topic><topic>Intestine</topic><topic>Pathology</topic><topic>Surgical outcomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laird, Ashleigh</creatorcontrib><creatorcontrib>Shekleton, Paul</creatorcontrib><creatorcontrib>Nataraja, Ramesh M.</creatorcontrib><creatorcontrib>Kimber, Christopher</creatorcontrib><creatorcontrib>Pacilli, Maurizio</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laird, Ashleigh</au><au>Shekleton, Paul</au><au>Nataraja, Ramesh M.</au><au>Kimber, Christopher</au><au>Pacilli, Maurizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of gastro‐intestinal anomalies and surgical outcome of fetuses diagnosed with echogenic bowel and bowel dilatation</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat Diagn</addtitle><date>2019-11</date><risdate>2019</risdate><volume>39</volume><issue>12</issue><spage>1115</spage><epage>1119</epage><pages>1115-1119</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><abstract>Background
We aimed to evaluate the incidence of gastro‐intestinal (GI) anomalies and surgical outcome in fetuses diagnosed with either echogenic bowel (EB) or EB plus bowel dilatation (BD) but no associated chromosomal, DNA and/or additional structural defects.
Methods
A 10‐year (2008‐2018) retrospective review was performed on all fetuses diagnosed with EB and EB+BD (RES‐18‐0000‐072Q). Results are reported as number of cases (%) and mean ±SD. Fisher's exact test, Mann‐Whitney U test and logistic regression were used to identify differences between groups and predisposing factors for gastro‐intestinal anomalies.
Results
We identified 41 fetuses with EB and 14 fetuses with EB+BD. Post‐natal surgical intervention was required in no patient of the EB group and in 7/14 (50%) of the EB+BD group, p<0.001. The risk of having a GI anomaly was higher in the EB+BD group (RR 42.0 [2.5‐691.6]; p=0.009). Advanced maternal age (p=0.04), ascites (p=0.006) and polyhydramnios (p=0.007) were associated with a higher incidence of GI pathology.
Conclusions
In fetuses with no associated chromosomal, DNA and/or additional structural defects, the finding of EB+BD is associated with 50% incidence of GI anomalies at birth. Advanced maternal age, ascites and polyhydramnios are also associated with higher incidence of GI pathology at birth.
What is already known on this topic:
Echogenic bowel and bowel dilatation are detected on fetal ultrasonographic examinations during the second and third trimesters.
Echogenic bowel and bowel dilatation can be secondary to underlying pathologies such as meconium ileus and other gastro‐intestinal tract abnormalities.
In fetuses with no associated chromosomal, DNA and/or additional structural defects, the findings of echogenic bowel and bowel dilatation poses a significant dilemma for antenatal counselling and planning of post‐natal management.
What this study adds:
Echogenic bowel in conjunction with bowel dilatation is associated with 50% incidence of gastro‐intestinal anomalies requiring surgical intervention at birth.
The presence of polyhydramnios, ascites and advanced maternal age, are associated with higher incidence of postnatal gastro‐intestinal pathology.
Fetuses diagnosed with echogenic bowel in conjunction with bowel dilatation despite not having associated chromosomal, DNA and/or additional structural defects, should be followed‐up and delivered in a paediatric surgical tertiary centre.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31461799</pmid><doi>10.1002/pd.5552</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-1259-4304</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Anomalies Ascites Birth Defects Deoxyribonucleic acid DNA Fetuses Health risk assessment Incidence Intestine Pathology Surgical outcomes |
| title | Incidence of gastro‐intestinal anomalies and surgical outcome of fetuses diagnosed with echogenic bowel and bowel dilatation |
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