TNF-α Suppresses Autophagic Flux in Acinar Cells in IgG4-Related Sialadenitis

IgG4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated systemic fibroinflammatory disease that affects salivary glands and leads to hyposalivation. Tumor necrosis factor–α (TNF-α) is a critical proinflammatory cytokine involved in several salivary gland disorders, but its role and...

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Veröffentlicht in:	Journal of dental research 2019-11, Vol.98 (12), p.1386-1396
Hauptverfasser:	Hong, X., Min, S.N., Zhang, Y.Y., Lin, Y.T., Wang, F., Huang, Y., Yu, G.Y., Wu, L.L., Yang, H.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Acinar cells Cathepsin D Cell injury Cytokines Dentistry Endoplasmic reticulum Extracellular signal-regulated kinase Immunofluorescence Immunoglobulin G Inflammation Lysosomes Mitochondria Phosphorylation Saliva Salivary gland Secretory vesicles Submandibular gland Transfection Tumor necrosis factor-TNF Tumor necrosis factor-α Vacuoles
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