Cholinergic deficits and galaninergic hyperinnervation of the nucleus basalis of Meynert in Alzheimer’s disease and Lewy body disorders

Aims Galanin is a highly inducible neuroprotective neuropeptide and in Alzheimer’s disease (AD), a network of galaninergic fibres has been reported to hypertrophy and hyperinnervate the surviving cholinergic neurons in the basal forebrain. We aimed to determine (i) the extent of galanin hyperinnerva...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2020-04, Vol.46 (3), p.264-278
Hauptverfasser:	Alexandris, A. S., Walker, L., Liu, A. K. L., McAleese, K. E., Johnson, M., Pearce, R. K. B., Gentleman, S. M., Attems, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferase Alzheimer's disease axonopathy Basal forebrain Choline Choline O-acetyltransferase cholinergic Cognitive ability Dementia Dementia disorders Disease Forebrain Galanin Hypertrophy Immunohistochemistry Innervation Lewy bodies Lewy body disease Movement disorders neurodegeneration Neurodegenerative diseases Neurons Neuroprotection Nucleus basalis Parkinson's disease Pathology Synuclein Tau protein
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