Single cohort study: ABO-incompatible kidney transplant recipients have a higher risk of lymphocele formation
Purpose Since 2004, ABO-incompatible kidney transplantation (ABOi KTx) became an established procedure to expand the living donor pool in Germany. Currently, ABOi KTx comprises > 20% of all living donor KTx. Up to September 2015, > 100 ABOi KTx were performed in Freiburg. Regarding lymphocele...
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| Veröffentlicht in: | Langenbeck's archives of surgery 2019-12, Vol.404 (8), p.999-1007 |
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| creator | Jänigen, Bernd Martin Salabè, Chiara Glatz, Torben Thomusch, Oliver Lässle, Claudia Fichtner-Feigl, Stefan Zschiedrich, Stefan Pisarski, Przemyslaw |
| description | Purpose
Since 2004, ABO-incompatible kidney transplantation (ABOi KTx) became an established procedure to expand the living donor pool in Germany. Currently, ABOi KTx comprises > 20% of all living donor KTx. Up to September 2015, > 100 ABOi KTx were performed in Freiburg. Regarding lymphocele formation, only scarce data exist.
Methods
Between April 2004 and September 2015, 106 consecutive ABOi and 277 consecutive ABO-compatible kidney transplantations (ABOc KTx) were performed. Two ABOi and 117 ABOc recipients were excluded due to differences in immunosuppression. One hundred-four ABOi and 160 ABOc KTx patients were analyzed concerning lymphocele formation.
Results
The incidence of lymphoceles in ABOi KTx was 25.2% and 10.6% in ABOc KTx (
p
= 0.003). A major risk factor appeared the frequency of ≥ 8 preoperative immunoadsorption and/or plasmapheresis sessions (OR 5.61, 95% CI 2.31–13.61,
p
|
| doi_str_mv | 10.1007/s00423-019-01812-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2281845542</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2281845542</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-3ca1498c118a5366d8b244733ac1b8456097674e3c090dd6d3de3c70eb448863</originalsourceid><addsrcrecordid>eNp9kL1OwzAUhS0EoqXwAgzII0vAjh0nYSsVf1KlDnS3HMdp3DZ2sBOkvD0uKR0ZLF_pnnN07gfALUYPGKH00SNEYxIhnIeX4TgazsAUU5JEMU3w-WmmZAKuvN8ihFia00swIZgmDKVsCppPbTZ7BaWtreug7_pyeILz51WkjbRNKzpdhPVOl0YNsHPC-HYvTAedkrrVynQe1uJbQQFrvamVg077HbQV3A9NW1upgruyrglB1lyDi0rsvbo5_jOwfn1ZL96j5ertYzFfRpLQtIuIFJjmmcQ4EwlhrMyKcEVKiJC4yA7V85SlVBGJclSWrCRlmFOkCkqzjJEZuB9jW2e_euU73mgfmoTiyvaex3GGQ0wS6M1APEqls947VfHW6Ua4gWPED5T5SJkHyvyXMh-C6e6Y3xeNKk-WP6xBQEaBDyuzUY5vbe9MOPm_2B9ZdYkr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2281845542</pqid></control><display><type>article</type><title>Single cohort study: ABO-incompatible kidney transplant recipients have a higher risk of lymphocele formation</title><source>SpringerLink Journals - AutoHoldings</source><creator>Jänigen, Bernd Martin ; Salabè, Chiara ; Glatz, Torben ; Thomusch, Oliver ; Lässle, Claudia ; Fichtner-Feigl, Stefan ; Zschiedrich, Stefan ; Pisarski, Przemyslaw</creator><creatorcontrib>Jänigen, Bernd Martin ; Salabè, Chiara ; Glatz, Torben ; Thomusch, Oliver ; Lässle, Claudia ; Fichtner-Feigl, Stefan ; Zschiedrich, Stefan ; Pisarski, Przemyslaw</creatorcontrib><description>Purpose
Since 2004, ABO-incompatible kidney transplantation (ABOi KTx) became an established procedure to expand the living donor pool in Germany. Currently, ABOi KTx comprises > 20% of all living donor KTx. Up to September 2015, > 100 ABOi KTx were performed in Freiburg. Regarding lymphocele formation, only scarce data exist.
Methods
Between April 2004 and September 2015, 106 consecutive ABOi and 277 consecutive ABO-compatible kidney transplantations (ABOc KTx) were performed. Two ABOi and 117 ABOc recipients were excluded due to differences in immunosuppression. One hundred-four ABOi and 160 ABOc KTx patients were analyzed concerning lymphocele formation.
Results
The incidence of lymphoceles in ABOi KTx was 25.2% and 10.6% in ABOc KTx (
p
= 0.003). A major risk factor appeared the frequency of ≥ 8 preoperative immunoadsorption and/or plasmapheresis sessions (OR 5.61, 95% CI 2.31–13.61,
p
< 0.001). Particularly, these ABOi KTx recipients had a distinctly higher risk of developing lymphocele (40.0% vs. 19.2%,
p
= 0.044). IA/PE sessions on day of transplantation (no lymphocele 20.0% vs. lymphocele 28.6%,
p
= 0.362) or postoperative IA/PE sessions (no lymphocele 25.7% vs. lymphocele 24.1%,
p
= 1.0) showed no influence on formation of lymphoceles.
Conclusion
In ABOi KTx, the incidence of lymphocele formation is significantly increased compared to ABOc KTx and leads to more frequent surgical reinterventions without having an impact on graft survival.</description><identifier>ISSN: 1435-2443</identifier><identifier>EISSN: 1435-2451</identifier><identifier>DOI: 10.1007/s00423-019-01812-y</identifier><identifier>PMID: 31456076</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdominal Surgery ; Cardiac Surgery ; General Surgery ; Medicine ; Medicine & Public Health ; Original Article ; Thoracic Surgery ; Traumatic Surgery ; Vascular Surgery</subject><ispartof>Langenbeck's archives of surgery, 2019-12, Vol.404 (8), p.999-1007</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-3ca1498c118a5366d8b244733ac1b8456097674e3c090dd6d3de3c70eb448863</citedby><cites>FETCH-LOGICAL-c347t-3ca1498c118a5366d8b244733ac1b8456097674e3c090dd6d3de3c70eb448863</cites><orcidid>0000-0001-9401-8815</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00423-019-01812-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00423-019-01812-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31456076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jänigen, Bernd Martin</creatorcontrib><creatorcontrib>Salabè, Chiara</creatorcontrib><creatorcontrib>Glatz, Torben</creatorcontrib><creatorcontrib>Thomusch, Oliver</creatorcontrib><creatorcontrib>Lässle, Claudia</creatorcontrib><creatorcontrib>Fichtner-Feigl, Stefan</creatorcontrib><creatorcontrib>Zschiedrich, Stefan</creatorcontrib><creatorcontrib>Pisarski, Przemyslaw</creatorcontrib><title>Single cohort study: ABO-incompatible kidney transplant recipients have a higher risk of lymphocele formation</title><title>Langenbeck's archives of surgery</title><addtitle>Langenbecks Arch Surg</addtitle><addtitle>Langenbecks Arch Surg</addtitle><description>Purpose
Since 2004, ABO-incompatible kidney transplantation (ABOi KTx) became an established procedure to expand the living donor pool in Germany. Currently, ABOi KTx comprises > 20% of all living donor KTx. Up to September 2015, > 100 ABOi KTx were performed in Freiburg. Regarding lymphocele formation, only scarce data exist.
Methods
Between April 2004 and September 2015, 106 consecutive ABOi and 277 consecutive ABO-compatible kidney transplantations (ABOc KTx) were performed. Two ABOi and 117 ABOc recipients were excluded due to differences in immunosuppression. One hundred-four ABOi and 160 ABOc KTx patients were analyzed concerning lymphocele formation.
Results
The incidence of lymphoceles in ABOi KTx was 25.2% and 10.6% in ABOc KTx (
p
= 0.003). A major risk factor appeared the frequency of ≥ 8 preoperative immunoadsorption and/or plasmapheresis sessions (OR 5.61, 95% CI 2.31–13.61,
p
< 0.001). Particularly, these ABOi KTx recipients had a distinctly higher risk of developing lymphocele (40.0% vs. 19.2%,
p
= 0.044). IA/PE sessions on day of transplantation (no lymphocele 20.0% vs. lymphocele 28.6%,
p
= 0.362) or postoperative IA/PE sessions (no lymphocele 25.7% vs. lymphocele 24.1%,
p
= 1.0) showed no influence on formation of lymphoceles.
Conclusion
In ABOi KTx, the incidence of lymphocele formation is significantly increased compared to ABOc KTx and leads to more frequent surgical reinterventions without having an impact on graft survival.</description><subject>Abdominal Surgery</subject><subject>Cardiac Surgery</subject><subject>General Surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Thoracic Surgery</subject><subject>Traumatic Surgery</subject><subject>Vascular Surgery</subject><issn>1435-2443</issn><issn>1435-2451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kL1OwzAUhS0EoqXwAgzII0vAjh0nYSsVf1KlDnS3HMdp3DZ2sBOkvD0uKR0ZLF_pnnN07gfALUYPGKH00SNEYxIhnIeX4TgazsAUU5JEMU3w-WmmZAKuvN8ihFia00swIZgmDKVsCppPbTZ7BaWtreug7_pyeILz51WkjbRNKzpdhPVOl0YNsHPC-HYvTAedkrrVynQe1uJbQQFrvamVg077HbQV3A9NW1upgruyrglB1lyDi0rsvbo5_jOwfn1ZL96j5ertYzFfRpLQtIuIFJjmmcQ4EwlhrMyKcEVKiJC4yA7V85SlVBGJclSWrCRlmFOkCkqzjJEZuB9jW2e_euU73mgfmoTiyvaex3GGQ0wS6M1APEqls947VfHW6Ua4gWPED5T5SJkHyvyXMh-C6e6Y3xeNKk-WP6xBQEaBDyuzUY5vbe9MOPm_2B9ZdYkr</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Jänigen, Bernd Martin</creator><creator>Salabè, Chiara</creator><creator>Glatz, Torben</creator><creator>Thomusch, Oliver</creator><creator>Lässle, Claudia</creator><creator>Fichtner-Feigl, Stefan</creator><creator>Zschiedrich, Stefan</creator><creator>Pisarski, Przemyslaw</creator><general>Springer Berlin Heidelberg</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9401-8815</orcidid></search><sort><creationdate>20191201</creationdate><title>Single cohort study: ABO-incompatible kidney transplant recipients have a higher risk of lymphocele formation</title><author>Jänigen, Bernd Martin ; Salabè, Chiara ; Glatz, Torben ; Thomusch, Oliver ; Lässle, Claudia ; Fichtner-Feigl, Stefan ; Zschiedrich, Stefan ; Pisarski, Przemyslaw</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-3ca1498c118a5366d8b244733ac1b8456097674e3c090dd6d3de3c70eb448863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdominal Surgery</topic><topic>Cardiac Surgery</topic><topic>General Surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Thoracic Surgery</topic><topic>Traumatic Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jänigen, Bernd Martin</creatorcontrib><creatorcontrib>Salabè, Chiara</creatorcontrib><creatorcontrib>Glatz, Torben</creatorcontrib><creatorcontrib>Thomusch, Oliver</creatorcontrib><creatorcontrib>Lässle, Claudia</creatorcontrib><creatorcontrib>Fichtner-Feigl, Stefan</creatorcontrib><creatorcontrib>Zschiedrich, Stefan</creatorcontrib><creatorcontrib>Pisarski, Przemyslaw</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langenbeck's archives of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jänigen, Bernd Martin</au><au>Salabè, Chiara</au><au>Glatz, Torben</au><au>Thomusch, Oliver</au><au>Lässle, Claudia</au><au>Fichtner-Feigl, Stefan</au><au>Zschiedrich, Stefan</au><au>Pisarski, Przemyslaw</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single cohort study: ABO-incompatible kidney transplant recipients have a higher risk of lymphocele formation</atitle><jtitle>Langenbeck's archives of surgery</jtitle><stitle>Langenbecks Arch Surg</stitle><addtitle>Langenbecks Arch Surg</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>404</volume><issue>8</issue><spage>999</spage><epage>1007</epage><pages>999-1007</pages><issn>1435-2443</issn><eissn>1435-2451</eissn><abstract>Purpose
Since 2004, ABO-incompatible kidney transplantation (ABOi KTx) became an established procedure to expand the living donor pool in Germany. Currently, ABOi KTx comprises > 20% of all living donor KTx. Up to September 2015, > 100 ABOi KTx were performed in Freiburg. Regarding lymphocele formation, only scarce data exist.
Methods
Between April 2004 and September 2015, 106 consecutive ABOi and 277 consecutive ABO-compatible kidney transplantations (ABOc KTx) were performed. Two ABOi and 117 ABOc recipients were excluded due to differences in immunosuppression. One hundred-four ABOi and 160 ABOc KTx patients were analyzed concerning lymphocele formation.
Results
The incidence of lymphoceles in ABOi KTx was 25.2% and 10.6% in ABOc KTx (
p
= 0.003). A major risk factor appeared the frequency of ≥ 8 preoperative immunoadsorption and/or plasmapheresis sessions (OR 5.61, 95% CI 2.31–13.61,
p
< 0.001). Particularly, these ABOi KTx recipients had a distinctly higher risk of developing lymphocele (40.0% vs. 19.2%,
p
= 0.044). IA/PE sessions on day of transplantation (no lymphocele 20.0% vs. lymphocele 28.6%,
p
= 0.362) or postoperative IA/PE sessions (no lymphocele 25.7% vs. lymphocele 24.1%,
p
= 1.0) showed no influence on formation of lymphoceles.
Conclusion
In ABOi KTx, the incidence of lymphocele formation is significantly increased compared to ABOc KTx and leads to more frequent surgical reinterventions without having an impact on graft survival.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31456076</pmid><doi>10.1007/s00423-019-01812-y</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9401-8815</orcidid></addata></record> |
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| subjects | Abdominal Surgery Cardiac Surgery General Surgery Medicine Medicine & Public Health Original Article Thoracic Surgery Traumatic Surgery Vascular Surgery |
| title | Single cohort study: ABO-incompatible kidney transplant recipients have a higher risk of lymphocele formation |
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